1st Edition - September 24, 2010

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  • Authors: Giuseppi Nappi, Michael Moskowitz

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Handbook of Clinical Neurology: Headache covers various aspects of headaches. It covers up-to-date information about the cultural developments and the scientific advances in the field of neurological science. One of the most frequent symptoms that people encounter is migraine or other type of headaches. At least 40% of neurological consultations are headache-related. With this, significant advances in basic and applied brain sciences have emerged in the field of headache-related problems. Divided into six sections, the book discusses the socioeconomic aspects of headaches, the contribution of biological sciences to the study of the pathophysiology of headache, and the management of headache and other related problems. It also deals with headache-related issues, such as pathogenic (chronobiological, endocrinological, and neuroimaging correlates), nosographic (i.e., migraine, vertigo, and headache in children), and treatment-related issues. The book will serve as a reference for researchers, clinical physicians, and other readers who want additional knowledge about the clinical features of headaches.

Key Features

  • A comprehensive guide to the advancements made in headache research and medicine, including the role of genetics and genomics
  • An exhaustive accounting of cultural developments and scientific advances in headache medicine
  • Critical information on primary and secondary headaches, including new therapies, prevention techniques, and management protocols

Table of Contents

  • Foreword



    List of contributors

    Section 1 General aspects

    1. Epidemiology of headache

    2. The social impact and burden of headache

    Section 2 Biological science of headache

    3. Biological sciences related to headache

    4. Pharmacology

    5. Biological science of headache channels

    6. Genetics of headaches

    7. The neurobiology of migraine

    8. Experimental models of migraine

    Section 3 Management of headache

    9. Management of headache patients

    10. Headache diaries and calendars

    11. Implementing the International Classification of Headache Disorders, 2nd edition (ICHD-II)

    12. Triggers of migraine and tension-type headache

    13. Acute headache in the emergency department

    14. Therapeutic guidelines for headache

    15. The role of prevention

    16. Managing migraine associated with sensitization

    17. Botulinum neurotoxin in the treatment of headache disorders

    18. The approach to the difficult patient

    19. Ethical issues in headache management

    20. The role of lay associations

    Section 4 Primary headache

    21. Migraine: general aspects

    22. Pathophysiology of migraine

    23. Migraine – clinical neurophysiology

    24. Migraine: clinical diagnostic criteria

    25. Migraine and reproductive life

    26. Acute treatment of migraine

    27. Migraine: preventive treatment

    28. Tension-type headache: introduction and diagnostic criteria

    29. Tension-type headache: mechanisms

    30. The clinical neurophysiology of tension-type headache

    31. Treatment of tension-type headache

    32. Cluster headache and trigeminal autonomic cephalalgias: general aspects

    33. Pathophysiology of cluster headache and other trigeminal autonomic cephalalgias

    34. Neuroimaging and clinical neurophysiology in cluster headache and trigeminal autonomic cephalalgias

    35. Cluster headache and other trigeminal autonomic cephalalgias: diagnostic criteria

    36. Acute and preventive treatment of cluster headache and other trigeminal autonomic cephalgias

    37. Neurostimulation therapy in intractable headaches

    38. Other primary headache – general aspects

    39. Primary stabbing headache

    40. Primary cough headache, primary exertional headache, and primary headache associated with sexual activity

    41. Hypnic headache

    42. Primary thunderclap headache

    43. Hemicrania continua

    44. New daily persistent headache

    Section 5 Secondary headaches

    45. Secondary headaches: introduction

    46. Headache attributed to head or neck trauma

    47. Headache attributed to stroke, TIA, intracerebral haemorrhage, or vascular malformation

    48. Headache attributed to arteritis, cerebral venous thrombosis, and other vascular intracranial disturbances

    49. Headache attributed to carotid or vertebral artery pain

    50. Headache attributed to non-vascular intracranial disorder

    51. Headache attributed to a substance or its withdrawal

    52. Headache attributed to infections: nosography and differential diagnosis

    53. Headache attributed to disorders of homeostasis

    54. Headache or facial pain attributed to disorders of cranium, neck, eyes, ears, nose, sinuses, teeth, mouth, or other facial or cranial structures

    55. Headache attributed to psychiatric disorders

    56. Cranial neuralgias

    57. Surgical treatment of cranial neuralgias

    58. Central pain in the face and head

    Section 6 Special issues

    59. Chronobiological correlates of primary headaches

    60. Headache: endocrinological aspects

    61. Headache in children

    62. Vestibular migraine

    63. Pharmacological migraine provocation: a human model of migraine

    64. Neuroimaging in headache

    65. Current and emerging therapies for migraine prevention and treatment


Product details

  • No. of pages: 856
  • Language: English
  • Copyright: © Elsevier 2010
  • Published: September 24, 2010
  • Imprint: Elsevier

About the Authors

Giuseppi Nappi

Affiliations and Expertise

IRCSS Mondino, Pavia and Rome, Italy

Michael Moskowitz

Affiliations and Expertise

Professor of Neurology, Harvard-MIT Division of Health Science and Technology, Boston, MA, USA.

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