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Headache - 1st Edition - ISBN: 9780444521392, 9780444534842

Headache, Volume 97

1st Edition

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Authors: Giuseppi Nappi Michael Moskowitz
Hardcover ISBN: 9780444521392
eBook ISBN: 9780444534842
Imprint: Elsevier
Published Date: 24th September 2010
Page Count: 856
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Table of Contents




List of contributors

Section 1 General aspects

1. Epidemiology of headache

2. The social impact and burden of headache

Section 2 Biological science of headache

3. Biological sciences related to headache

4. Pharmacology

5. Biological science of headache channels

6. Genetics of headaches

7. The neurobiology of migraine

8. Experimental models of migraine

Section 3 Management of headache

9. Management of headache patients

10. Headache diaries and calendars

11. Implementing the International Classification of Headache Disorders, 2nd edition (ICHD-II)

12. Triggers of migraine and tension-type headache

13. Acute headache in the emergency department

14. Therapeutic guidelines for headache

15. The role of prevention

16. Managing migraine associated with sensitization

17. Botulinum neurotoxin in the treatment of headache disorders

18. The approach to the difficult patient

19. Ethical issues in headache management

20. The role of lay associations

Section 4 Primary headache

21. Migraine: general aspects

22. Pathophysiology of migraine

23. Migraine – clinical neurophysiology

24. Migraine: clinical diagnostic criteria

25. Migraine and reproductive life

26. Acute treatment of migraine

27. Migraine: preventive treatment

28. Tension-type headache: introduction and diagnostic criteria

29. Tension-type headache: mechanisms

30. The clinical neurophysiology of tension-type headache

31. Treatment of tension-type headache

32. Cluster headache and trigeminal autonomic cephalalgias: general aspects

33. Pathophysiology of cluster headache and other trigeminal autonomic cephalalgias

34. Neuroimaging and clinical neurophysiology in cluster headache and trigeminal autonomic cephalalgias

35. Cluster headache and other trigeminal autonomic cephalalgias: diagnostic criteria

36. Acute and preventive treatment of cluster headache and other trigeminal autonomic cephalgias

37. Neurostimulation therapy in intractable headaches

38. Other primary headache – general aspects

39. Primary stabbing headache

40. Primary cough headache, primary exertional headache, and primary headache associated with sexual activity

41. Hypnic headache

42. Primary thunderclap headache

43. Hemicrania continua

44. New daily persistent headache

Section 5 Secondary headaches

45. Secondary headaches: introduction

46. Headache attributed to head or neck trauma

47. Headache attributed to stroke, TIA, intracerebral haemorrhage, or vascular malformation

48. Headache attributed to arteritis, cerebral venous thrombosis, and other vascular intracranial disturbances

49. Headache attributed to carotid or vertebral artery pain

50. Headache attributed to non-vascular intracranial disorder

51. Headache attributed to a substance or its withdrawal

52. Headache attributed to infections: nosography and differential diagnosis

53. Headache attributed to disorders of homeostasis

54. Headache or facial pain attributed to disorders of cranium, neck, eyes, ears, nose, sinuses, teeth, mouth, or other facial or cranial structures

55. Headache attributed to psychiatric disorders

56. Cranial neuralgias

57. Surgical treatment of cranial neuralgias

58. Central pain in the face and head

Section 6 Special issues

59. Chronobiological correlates of primary headaches

60. Headache: endocrinological aspects

61. Headache in children

62. Vestibular migraine

63. Pharmacological migraine provocation: a human model of migraine

64. Neuroimaging in headache

65. Current and emerging therapies for migraine prevention and treatment



Handbook of Clinical Neurology: Headache covers various aspects of headaches. It covers up-to-date information about the cultural developments and the scientific advances in the field of neurological science. One of the most frequent symptoms that people encounter is migraine or other type of headaches. At least 40% of neurological consultations are headache-related. With this, significant advances in basic and applied brain sciences have emerged in the field of headache-related problems.

Divided into six sections, the book discusses the socioeconomic aspects of headaches, the contribution of biological sciences to the study of the pathophysiology of headache, and the management of headache and other related problems. It also deals with headache-related issues, such as pathogenic (chronobiological, endocrinological, and neuroimaging correlates), nosographic (i.e., migraine, vertigo, and headache in children), and treatment-related issues.

The book will serve as a reference for researchers, clinical physicians, and other readers who want additional knowledge about the clinical features of headaches.

Key Features

  • A comprehensive guide to the advancements made in headache research and medicine, including the role of genetics and genomics
  • An exhaustive accounting of cultural developments and scientific advances in headache medicine
  • Critical information on primary and secondary headaches, including new therapies, prevention techniques, and management protocols


No. of pages:
© Elsevier 2011
24th September 2010
Hardcover ISBN:
eBook ISBN:


"This book offers a complete overview and update of the scientific and cultural developments that, since the publication of the previous Handbook on headaches, have revolutionised understanding of migraine and other headaches. This process was made possible by the fact that many of the distinguished authors who contributed to the book have been protagonists in the advancement of headache science in recent decades. The aim of the publishers of this third edition of the Handbook was to provide basic researchers and clinicians with an updated bibliographical resource that would increase all-round knowledge of the various forms of headache and also provide pointers for new lines of research. On reading this book it is clear that Professors Nappi and Moskowitz have accomplished this arduous task. The broad range of different skills and backgrounds (not only geographical but also cultural) of the editors and co-authors of this book not only provide a guarantee of its undisputed scientific quality, but also give it an international dimension." --Functional Neurology, 2012

Ratings and Reviews

About the Authors

Giuseppi Nappi

Affiliations and Expertise

IRCSS Mondino, Pavia and Rome, Italy

Michael Moskowitz

Affiliations and Expertise

Professor of Neurology, Harvard-MIT Division of Health Science and Technology, Boston, MA, USA.