Headache, Volume 97

1st Edition

Authors: Giuseppi Nappi Michael Moskowitz
Hardcover ISBN: 9780444521392
eBook ISBN: 9780444534842
Imprint: Elsevier
Published Date: 24th September 2010
Page Count: 856


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Table of Contents

Foreword Preface Dedication List of contributors Section 1 General aspects

1. Epidemiology of headache 2. The social impact and burden of headache

Section 2 Biological science of headache

3. Biological sciences related to headache 4. Pharmacology 5. Biological science of headache channels 6. Genetics of headaches 7. The neurobiology of migraine 8. Experimental models of migraine

Section 3 Management of headache

9. Management of headache patients 10. Headache diaries and calendars 11. Implementing the International Classification of Headache Disorders, 2nd edition (ICHD-II) 12. Triggers of migraine and tension-type headache 13. Acute headache in the emergency department 14. Therapeutic guidelines for headache 15. The role of prevention 16. Managing migraine associated with sensitization 17. Botulinum neurotoxin in the treatment of headache disorders 18. The approach to the difficult patient 19. Ethical issues in headache management 20. The role of lay associations

Section 4 Primary headache

21. Migraine: general aspects 22. Pathophysiology of migraine 23. Migraine – clinical neurophysiology 24. Migraine: clinical diagnostic criteria 25. Migraine and reproductive life 26. Acute treatment of migraine 27. Migraine: preventive treatment 28. Tension-type headache: introduction and diagnostic criteria 29. Tension-type headache: mechanisms 30. The clinical neurophysiology of tension-type headache 31. Treatment of tension-type headache 32. Cluster headache and trigeminal autonomic cephalalgias: general aspects 33. Pathophysiology of cluster headache and other trigeminal autonomic cephalalgias 34. Neuroimaging and clinical neurophysiology in cluster headache and trigeminal autonomic cephalalgias 35. Cluster headache and other trigeminal autonomic cephalalgias: di


Handbook of Clinical Neurology: Headache covers various aspects of headaches. It covers up-to-date information about the cultural developments and the scientific advances in the field of neurological science. One of the most frequent symptoms that people encounter is migraine or other type of headaches. At least 40% of neurological consultations are headache-related. With this, significant advances in basic and applied brain sciences have emerged in the field of headache-related problems.

Divided into six sections, the book discusses the socioeconomic aspects of headaches, the contribution of biological sciences to the study of the pathophysiology of headache, and the management of headache and other related problems. It also deals with headache-related issues, such as pathogenic (chronobiological, endocrinological, and neuroimaging correlates), nosographic (i.e., migraine, vertigo, and headache in children), and treatment-related issues.

The book will serve as a reference for researchers, clinical physicians, and other readers who want additional knowledge about the clinical features of headaches.

Key Features

  • A comprehensive guide to the advancements made in headache research and medicine, including the role of genetics and genomics
  • An exhaustive accounting of cultural developments and scientific advances in headache medicine
  • Critical information on primary and secondary headaches, including new therapies, prevention techniques, and management protocols


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© Elsevier 2011
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"This book offers a complete overview and update of the scientific and cultural developments that, since the publication of the previous Handbook on headaches, have revolutionised understanding of migraine and other headaches. This process was made possible by the fact that many of the distinguished authors who contributed to the book have been protagonists in the advancement of headache science in recent decades. The aim of the publishers of this third edition of the Handbook was to provide basic researchers and clinicians with an updated bibliographical resource that would increase all-round knowledge of the various forms of headache and also provide pointers for new lines of research. On reading this book it is clear that Professors Nappi and Moskowitz have accomplished this arduous task. The broad range of different skills and backgrounds (not only geographical but also cultural) of the editors and co-authors of this book not only provide a guarantee of its undisputed scientific quality, but also give it an international dimension." --Functional Neurology, 2012

About the Authors

Giuseppi Nappi Author

Affiliations and Expertise

IRCSS Mondino, Pavia and Rome, Italy

Michael Moskowitz Author

Affiliations and Expertise

Professor of Neurology, Harvard-MIT Division of Health Science and Technology, Boston, MA, USA.