Haschek and Rousseaux's Handbook of Toxicologic Pathology - 2nd Edition - ISBN: 9780123302151, 9780080491448

Haschek and Rousseaux's Handbook of Toxicologic Pathology

2nd Edition

Editor-in-Chiefs: Wanda Haschek
Editors: Wanda Haschek Colin Rousseaux Matthew Wallig
Hardcover ISBN: 9780123302151
eBook ISBN: 9780080491448
Imprint: Academic Press
Published Date: 8th October 2001
Page Count: 1706
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A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology.
This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.

Key Features

Key Features

  • Easy to find, up-to-date reference information
  • Graphic and photographic plates
  • Current hot topics and anticipated changes in toxicologic pathology
  • Standardized chapter format
  • Topics that are addressed in both a broad and deep manner, resulting in a stand alone text
  • Added coverage of important environmental toxicants
  • Chapters authored by internationally recognized experts and peer-reviewed


Researchers in the area of toxicology and pathology, veterinary scientists, veterinary diagnostic and medical forensic laboratories, and pharmaceutical and chemical companies.

Table of Contents

Volume 1: General Toxicologic Pathology

Preface. Contributors.

Part A: Basics of Toxicologic Pathology Toxicologic Pathology: An Introduction. Biochemical Basis of Toxicity. Morphologic Manifestation of Toxic Cell Injury. Organelle Biochemistry and Regulation of Cell Death. Carcinogenesis. Applied Clinical Pathology in Preclinical Toxicology Testing. Nomenclature. Part B: The Practice of Toxicologic Pathology Basic Techniques. Managing Pitfalls in Toxicologic Pathology. Special Techniques in Toxicologic Pathology. Application of New Technologies to Toxicologic Pathology. Issues in Laboratory Animal Science for the Toxicologic Pathologist. New Animal Models in Toxicology. Pathology Issues in the Design of Toxicology Studies. Use and Misuse of Statistics in the Design and Interpretation of Studies. Preparation of the Report for a Toxicology/Pathology Study. Part C: Selected Topics in Toxicologic Pathology Risk Assessment: The Changing Paradigm. Principles of Risk Communication: Building Trust and Credibility with the Public. Biomedical Devices and Biomaterials. Biotechnology and Its Products. Endocrine Disruptors. Radiation and Heat. Nutritional Toxicologic Pathology. Phycotoxins. Mycotoxins. Heavy Metals. Volume 2: Organ Specific Toxicologic Pathology

Organ-Specific Toxicologic Pathology: An Introduction. Respiratory System. Skin and Oral Mucosa. Gastrointestinal Tract. Liver. Pancreas. Kidney. Lower Urinary Tract. Cardiovascular and Skeletal Muscle Systems. Bones and Joints. Nervous System. The Eye. Immune System. Hematopoietic System. Endocrine System. Male Reproduction. Female Reproduction. Embryo and Fetus.



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© Academic Press 2002
Academic Press
Hardcover ISBN:
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About the Editor-in-Chief

Wanda Haschek

Affiliations and Expertise

University of Illinois at Urbana-Champaign

About the Editor

Wanda Haschek

Affiliations and Expertise

University of Illinois at Urbana-Champaign

Colin Rousseaux

Affiliations and Expertise

University of Ottawa

Matthew Wallig

Affiliations and Expertise

University of Illinois at Urbana-Champaign


"The 2 volumes are excellent companions that complement each other as a "1,2" punch! This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."
"...gives an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional."
"...very readable, well-referenced, and current... an excellent book for research training."

"[W]ell illustrated with good quality diagrams, colour and black and white photographs…. [A]n excellent, eminently readable book to have as a study or reference book, covering the essential basics and providing a good overview for any toxicological pathologist, toxicologist or research scientist with an interest in the pathological changes seen in toxicological studies."--British Toxicology Society Newsletter