Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 4: Toxicologic Pathology of Organ Systems

4th Edition - March 5, 2024
Editors: Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 0 4 6 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 2 8 2 - 4

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functi… Read more

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 4: Toxicologic Pathology of Organ Systems

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Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the Editors
Preface
Chapter 1. Digestive Tract and Salivary Glands
1. Introduction
2. Structure and Function of the Digestive Tract
3. Evaluation of Digestive Toxicity
4. Response of the Digestive Tract to Injury
5. Mechanisms of Digestive Toxicity
6. Issues in Drug Development
7. Regulatory Issues
8. Conclusion
Chapter 2. Liver and Gall Bladder
1. Introduction
2. Structure, Function, and Cell Biology
3. Evaluation of Toxicity
4. Response of Liver and Gall Bladder to Injury
5. Mechanisms of Toxicity in Liver
6. Issues in Drug Development
7. Regulatory Guidance and Best Practice Recommendations
8. Summary
Chapter 3. Bones, Joints, and Teeth
1. Introduction
2. Bones and Joints
3. Teeth
Glossary: Bones and Joints
Glossary: Teeth
Chapter 4. Muscle and Tendon
1. Skeletal Muscle
2. Smooth Muscle
3. Tendon
Summary
Glossary
Chapter 5. Exocrine Pancreas
1. Introduction
2. Normal Structure, Function, and Cell Biology
3. Evaluation of Toxicity
4. Responses of Exocrine Pancreas to Injury
5. Mechanisms of Exocrine Pancreatic Toxicity
6. Issues in Drug Development
7. Regulatory Issues
8. Conclusion
Chapter 6. Adipose Tissues
1. Introduction
2. Part I: White Adipose Tissue
3. Part II: Brown Adipose Tissue
4. Part III: Bone Marrow Adipose Tissue
5. Perspectives/Translational Aspects
6. Conclusions
Chapter 7. Endocrine System
1. Introduction
2. Adrenal Cortex
3. Adrenal Medulla
4. Pituitary Gland
5. Thyroid C Cells
6. Thyroid Follicular Cells
7. Parathyroid Gland
8. Endocrine Pancreas
9. Endocrine Disruption and Endocrine-Disrupting Compounds
Chapter 8. Nervous System
1. Introduction
2. Architecture and Function of the Nervous System
3. Neurotoxicity Assessment
4. Mechanisms of Nervous System Injury
5. Responses to Neurotoxic Injury
6. Regulatory Perspectives on Neuropathology Evaluation
7. Conclusions
Chapter 9. The Eye
1. Introduction
2. Structure and Function
3. Evaluation of Toxicity
4. Response to Injury and Mechanisms of Toxicity
5. Conclusions
Glossary of Ocular Terminology
Chapter 10. Ear
1. Introduction
2. Structure and Function
3. Testing for Otic Toxicity
4. Responses to Injury and Mechanisms of Injury
5. Conclusions
Index

Wanda M. Haschek

Wanda M. Haschek-Hock, BVSc, Ph.D., is a Diplomate of the American College of Veterinary Pathologists (DACVP), Fellow of the International Academy of Toxicologic Pathology (FIATP), and Honorary Member of the Latin American Society of Toxicologic Pathology. She is Professor Emerita at the University of Illinois College of Veterinary Medicine, Department of Pathobiology. Wanda has over 40 years of experience in comparative, respiratory, and toxicologic pathology with a research focus on natural toxins and food safety. She is a former President of the Society of Toxicologic Pathology (STP) and of the Society of Toxicology’s (SOT) Comparative and Veterinary Specialty Section and has served as an Associate Editor for Toxicological Sciences and Toxicologic Pathology, as Councilor of the American College of Veterinary Pathologists (ACVP), and as Member of the American Board of Toxicology (ABT). She served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. She is a recipient of the STP’s Lifetime Achievement Award, the SOT Midwest Regional Chapter’s Kenneth DuBois Award, and the University of Sydney Faculty of Veterinary Science Alumni Award for International Achievement in 2016.

Affiliations and expertise

Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Colin G. Rousseaux

Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

Affiliations and expertise

Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa Principal, Colin Rousseaux and Associates, Canada

Matthew A. Wallig

Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

Affiliations and expertise

Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Brad Bolon

Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

Affiliations and expertise

President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA