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Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Two, Fourth Edition is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Sections discuss Toxicologic Pathology in Product Discovery and Safety Assessment, Safety Assessment and Data Interpretation, and Food and the Environment: Selected Toxic Agents. Completely revised with new chapters, this book is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.
- Provides new chapters on gene therapy, stem cells, regenerative medicine, genome editing, and in-depth discussions of timely topics in toxicologic pathology
- Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
- Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations
Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories; regulatory agencies and universities
PART 1: Toxicologic Pathology in Product Discovery and Safety Assessment
1. Overview of Drug Development
2. Overview of the Role of Pathology in Product Discovery and Safety Assessment
3. Discovery Toxicology and Pathology
4. Pathology in Non-Clinical Drug Safety Assessment
6. Biomedical Materials and Devices
7. Carcinogenicity Assessment
PART 2: Safety Assessment and Data Interpretation
8. Preparation of the Pathology Report for a Toxicology Study
9. Interpretation of Clinical Pathology Results in Non-Clinical Toxicology Testing
10. Statistical Assessment of Toxicologic Pathology Studies
11. Risk Assessment
12. Risk Communication for Toxicologic Pathologists
13. Risk Management in Non-Clinical Drug Development
PART 3: Food and the Environment: Selected Toxic Agents
14. Environmental Toxicologic Pathology and Human Health
15. Food and Toxicologic Pathology: An Overview
16. Nutritional Toxicologic Pathology
17. Endocrine Disruptors
20. Selected Poisonous Plants Affecting Animal and Human Health
21. Heavy Metals
22. Agricultural Chemicals
24. Radiation and Other Physical Agents
- No. of pages:
- © Academic Press 2022
- 1st January 2022
- Academic Press
- Hardcover ISBN:
Wanda M Haschek-Hock, BVSc, PhD, DACVP, FIATP, Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011.
Professor Emerita, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
Professor Rousseaux, BVSc [Hons], PhD, DABT, FRCPath, FIATP, FATS is a Fellow of the Royal College of Pathology, Diplomate of the American Board of Toxicology, Fellow of the Academy of Toxicological Sciences, and Fellow of the International Academy of Toxicologic Pathology. He is Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceutical, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former president of the Society of Toxicologic Pathology.
Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa, Principal, Colin Rousseaux and Associates, Canada
Professor Wallig, DVM, PhD, DACVP is a Diplomate of the American College of Veterinary Pathologists. He is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables and soy, and the pathophysiology of pancreatic injury.
Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
Brad Bolan, DVM, MS, PhD, SACVP, DABT, FATS, FIATP, President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA During a 25-year career, Dr. Bolon has been employed in academia, contract research organizations, and two pharmaceutical firms before launching an experimental and toxicologic pathology practice. His main professional interests include comparative pathology of genetically engineered animals and toxicologic neuropathology. He is a past president of the Society of Toxicologic Pathology and is a recipient of the 2018 British Society of Toxicological Pathology’s Gopinath Lecture Award for excellence in toxicologic pathology.
President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA
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