Handbook of the Biology of Aging

Handbook of the Biology of Aging

6th Edition - December 20, 2005

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  • Editors: Edward Masoro, Steven Austad
  • eBook ISBN: 9780080491400

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The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.


Gerontological researchers, developmental psychologists, sociologists, practioners dealing with aging populations, biologists involved in aging research, & medical researchers.

Table of Contents


    Edited by Edward J. Masoro and Steve Austad

    Section I: Conceptual and Technical Issues

    Chapter 1
    Reliability Theory of Aging and Longevity
    Leonid A. Gavrilov and Natalia S. Gavrilova

    Chapter 2 - Are Age-Associated Diseases an Integral Part of Aging?
    Edward J. Masoro

    Chapter 3 - Dietary Restriction, Hormesis and Small Molecule Mimetics
    David A. Sinclair and Konrad T. Howitz

    Chapter 4 - Hematopoietic Stem Cells, Aging, and Cancer
    Deborah Bell and Gary Van Zant

    Chapter 5 - Mitochondria: A Critical Role in Aging
    Tamara Golden, Karl Morten, Felicity Johnson, Enrique Samper, and Simon Melov

    Chapter 6 - P53 and Mouse Aging Models
    Cathy Gatza, George Hinkal, Lynette Moore, Melissa Dumble, and Lawrence A. Donehower

    Chapter 7 - Complex Genetic Architecture of Drosophila Longevity
    Trudy Mackay, Natalia V. Roshina, Jeff W. Leips, and Elena G. Pasyukova

    Chapter 8 - Evolutionary Biology of Aging: Future Directions
    Daniel Promislow, Ken Fedorka, and Joep Burger

    Chapter 9 - Senescence in Wild Populations of Mammals and Birds
    Anja Brunet-Rossini and Steven N. Austad

    Chapter 10 - Biodemography of Aging and Age-Specific Mortality in Drosophila melanogaster
    James Curtsinger, Natalia S. Gavrilova, and Leonid A. Gavrilov

    Chapter 11 - Microarray Analysis of Gene Expression Changes in Aging
    F. Noel Hudson, Matt Kaeberlein, Nancy Linford, David Pritchard, Richard Beyer, and Peter S. Rabinovitch

    Chapter 12 - Computer Modeling in the Study of Aging
    Thomas Kirkwood, Richard Boys, Colin Gillespie, Carole Procter, Daryl Shanley, and Darren Wilkenson

    Section II: Non-Mammalian Models

    Chapter 13 - Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans
    Thomas E. Johnson, Samuel T. Henderson, Shane Rea

    Chapter 14 - Genetic Manipulation of Life span in Drosophila. Melanogaster
    Daniel Ford and John Tower

    Chapter 15 - Juvenile and Steroid Hormones in Drosophila melanogaster Longevity
    Meng-Ping Tu, Thomas Flatt,, Marc Tatar

    Chapter 16 - A Critical Evaluation of Nonmammalian Models for Aging Research
    Steven N. Austad, Andrej Podlutsky

    Section III: Mammalian Models

    Chapter 17 - Differential Aging Among Skeletal Muscles
    Roger J. M. McCarter

    Chapter 18 - Aging, Body Fat, and Carbohydrate Metabolism
    Marielisa Rincon, Radhika Muzumdar, and Nir Barzilai

    Chapter 19 - Growth and Aging: Why do Big Dogs Die young?
    Richard Miller and Steven N. Austad

    Chapter 20 - Growth Hormone, Insulin-Like Growth Factor-1 and the Biology of Aging
    Christy S. Carter and William E. Sonntag

    Chapter 21 - Aging of the Female Reproductive System
    Phyllis Wise

Product details

  • No. of pages: 680
  • Language: English
  • Copyright: © Academic Press 2005
  • Published: December 20, 2005
  • Imprint: Academic Press
  • eBook ISBN: 9780080491400

About the Editors

Edward Masoro

Edward J. Masoro was the recipient of the 1989 Allied-Signal Achievement Award in Aging Research. In 1990, he received the Geriatric Leadership Academic Award from the National Institute on Aging and the Robert W. Kleemeier Award from the Gerontological Society of America. In 1991, he received a medal of honor from the University of Pisa for Achievements in Gerontology. In 1993, Dr. Masoro received the Distinguished Service Award from the Association of Chairmen of Departments of Physiology. He received the 1995 Irving Wright Award of Distinction of the American Federation for Aging Research and the 1995 Glenn Foundation Award. He served as the President of the Gerontological Society of America from 1994–1995, as the Chairman of the Aging Review Committee of the National Institute on Aging (NIA), and as Chairman of the Board of Scientific Counselors of the NIA. Dr. Masoro received his Ph.D. from the University of California at Berkeley. He has held faculty positions at Queens University (Canada), Tufts University School of Medicine, University of Washington,and Medical College of Pennsylvania. From 1973 through May 1991, he served as Chairman of the Department of Physiology at the University of Texas Health Science Center at San Antonio. He presently continues his duties as Professor in the Department of Physiology and is the Director of the newly created Aging Research and Education Center. On April 1, 1996, he became Professor Emeritus. Dr. Masoro was a Wellcome Visiting Professor in Basic Medical Sciences for the 1992–1993 Academic Year. His research has been in lipid metabolism, cold exposure, membrane biochemistry, and biological gerontology. Since 1975, Dr. Masoros research has focused on the influence of food restriction on aging. He has or is serving in an editorial role for ten journals, and in January 1992, he became the Editor of the Journal of Gerontology: Biological Sciences.

Affiliations and Expertise

University of Texas, San Antonio, U.S.A.

Steven Austad

Affiliations and Expertise

University of Texas Health Science Center, San Antonio, TX, USA

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