Handbook of the Biology of Aging - 6th Edition - ISBN: 9780120883875, 9780080491400

Handbook of the Biology of Aging

6th Edition

eBook ISBN: 9780080491400
Hardcover ISBN: 9780120883875
Imprint: Academic Press
Published Date: 20th December 2005
Page Count: 680
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Table of Contents


Edited by Edward J. Masoro and Steve Austad

Section I: Conceptual and Technical Issues

Chapter 1 Reliability Theory of Aging and Longevity Leonid A. Gavrilov and Natalia S. Gavrilova

Chapter 2 - Are Age-Associated Diseases an Integral Part of Aging? Edward J. Masoro

Chapter 3 - Dietary Restriction, Hormesis and Small Molecule Mimetics David A. Sinclair and Konrad T. Howitz

Chapter 4 - Hematopoietic Stem Cells, Aging, and Cancer Deborah Bell and Gary Van Zant

Chapter 5 - Mitochondria: A Critical Role in Aging Tamara Golden, Karl Morten, Felicity Johnson, Enrique Samper, and Simon Melov

Chapter 6 - P53 and Mouse Aging Models Cathy Gatza, George Hinkal, Lynette Moore, Melissa Dumble, and Lawrence A. Donehower

Chapter 7 - Complex Genetic Architecture of Drosophila Longevity Trudy Mackay, Natalia V. Roshina, Jeff W. Leips, and Elena G. Pasyukova

Chapter 8 - Evolutionary Biology of Aging: Future Directions Daniel Promislow, Ken Fedorka, and Joep Burger

Chapter 9 - Senescence in Wild Populations of Mammals and Birds Anja Brunet-Rossini and Steven N. Austad

Chapter 10 - Biodemography of Aging and Age-Specific Mortality in Drosophila melanogaster James Curtsinger, Natalia S. Gavrilova, and Leonid A. Gavrilov

Chapter 11 - Microarray Analysis of Gene Expression Changes in Aging F. Noel Hudson, Matt Kaeberlein, Nancy Linford, David Pritchard, Richard Beyer, and Peter S. Rabinovitch

Chapter 12 - Computer Modeling in the Study of Aging
Thomas Kirkwood, Richard Boys, Colin Gillespie, Carole Procter, Daryl Shanley, and Darren Wilkenson

Section II: Non-Mammalian Models

Chapter 13 - Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans Thomas E. Johnson, Samuel T. Henderson, Shane Rea

Chapter 14 - Genetic Manipulation of Life span in Drosophila. Melanogaster Daniel Ford and John Tower

Chapter 15 - Juvenile and Steroid Hormones in Drosophila melanogaster Longevity Meng-Ping Tu, Thomas Flatt,, Marc Tatar

Chapter 16 - A Critical Evaluation of Nonmammalian Models for Aging Research Steven N. Austad, Andrej Podlutsky

Section III: Mammalian Models

Chapter 17 - Differential Aging Among Skeletal Muscles Roger J. M. McCarter

Chapter 18 - Aging, Body Fat, and Carbohydrate Metabolism Marielisa Rincon, Radhika Muzumdar, and Nir Barzilai

Chapter 19 - Growth and Aging: Why do Big Dogs Die young? Richard Miller and Steven N. Austad

Chapter 20 - Growth Hormone, Insulin-Like Growth Factor-1 and the Biology of Aging Christy S. Carter and William E. Sonntag

Chapter 21 - Aging of the Female Reproductive System
Phyllis Wise


The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses.

The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship.

The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging.

The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.


Gerontological researchers, developmental psychologists, sociologists, practioners dealing with aging populations, biologists involved in aging research, & medical researchers.


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© Academic Press 2005
Academic Press
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