Handbook of the Behavioral Neurobiology of Serotonin

Handbook of the Behavioral Neurobiology of Serotonin

2nd Edition - January 21, 2020

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  • Editors: Christian Muller, Kathryn Cunningham
  • Hardcover ISBN: 9780444641250
  • eBook ISBN: 9780444641267

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Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood.

Key Features

  • Features two new sections on serotonin systems interactions and serotonin in neurological disorders
  • Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior
  • Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes
  • Covers the interactions between serotonin, melatonin and kynurenine pathways


Advanced students and researchers in neuroscience, pharmacology, psychiatry, psychology, and neurology

Table of Contents

  • Section 1: Functional anatomy of the serotonergic system
    1.1 Evolution of serotonin: sunlight to suicide
    Efrain C. Azmitia
    1.2 From B1 to B9: a guide through hindbrain serotonin neurons with additional views from multidimensional characterization
    Mariano Soiza-Reilly and Patricia Gaspar
    1.3 Serotonin System Function, Organization and Feedback
    Kathryn G. Commons
    1.4 Ultrastructure of the serotonin innervation in mammalian central nervous system
    Martin Parent and Laurent Descarries
    1.5 Classification and Signaling Characteristics of 5-HT Receptors: Towards the Concept of 5-HT Receptosomes
    Philippe Marin, Carine Bécamel, Séverine Chaumont-Dubel, Franck Vandermoere, Joël Bockaert, and Sylvie Claeysen
    1.6 Distribution of 5-HT receptors in the central nervous system: An update
    M. Teresa Vilaró, Roser Cortés, Guadalupe Mengod, and Daniel Hoyer
    1.7 The serotonin2B receptor and neurochemical regulation in the brain
    Umberto Spampinato, Adeline Cathala, and Céline Devroye
    1.8 Electrochemical Detection of Serotonin Release in Rodents
    Rhiannon Robke, Aishwarya Parthasarathy, Ingo Willuhn, and Parastoo Hashemi
    1.9 Molecular neuroimaging of the serotonergic system with Positron Emission Tomography
    Silberbauer L, James GM, Spies M, Michenthaler P, Kranz GS, Kasper S, and Lanzenberger R

    Section 2: The neurophysiology of serotonin
    2.1 Serotonergic control of excitability: from neuron to networks
    Giuseppe Di Giovanni, Abdeslam Chagraoui, Rahul Bharatiya, and Philippe De Deurwaerdère
    2.2 Structure and function of serotonin GPCR heteromers
    Urjita Shah, Hanna Pincas, Stuart C. Sealfon, and Javier González-Maeso
    2.3 Tryptophan hydroxylase and serotonin synthesis regulation
    Donald M. Kuhn and Hiroyuki Hasegawa
    2.4 Serotonylation and neuronal function
    Nancy A. Muma and Khushboo Kapadia
    2.5 The effects of serotonin degradation on psychopathology: Role of monoamine oxidase
    Gabriele Floris, Roberto Cadeddu, and Marco Bortolato
    2.6 Cellular effects of serotonin in the CNS
    Rodrigo Andrade and Samir Haj-Dahmane
    2.7 Serotonin - lipid interactions and their role in behavior
    Liubov S. Kalinichenko, Erich Gulbins, Johannes Kornhuber, Christian P. Müller
    2.8 Serotonin – Pain Modulation
    Volker Neugebauer
    2.9 Serotonin regulation of striatal function
    Sunila G. Nair, Melissa M. Estabrook, and John F. Neumaier
    2.10 Serotonergic regulation of hippocampal rhythmical activity
    Robert P. Vertes and Stephanie B. Linley
    2.11 The loudness dependence of auditory evoked potentials as an electrophysiological marker of central serotonergic neurotransmission: implications for clinical psychiatry and psychopharmacotherapy
    Patrik Roser, Wolfram Kawohl, and Georg Juckel

    Section 3: Serotonin and systemic control
    3.1 5-HT neurons and central CO2 chemoreception
    Frida A. Teran and George B. Richerson
    3.2 Serotonin: a forgotten signal from the blood
    Paul M. Vanhoutte

    Section 4: Serotonin and behavioural control
    4.1 Serotonin and development
    Patricia M. Whitaker-Azmitia
    4.2 Roles of serotonin in the fetal brain
    Qiuying Zhao and Alexandre Bonnin
    4.3 Serotonin and sensory processing
    Mariana M. Marquez and Maurice J. Chacron
    4.4 Serotonin and basal sensory–motor control
    Robert J. Carey
    4.5 Role of the serotonergic system in appetite and ingestion control
    Michelle D. Lee and Peter G. Clifton
    4.6 Serotonin in eating behavior
    Valérie Compan
    4.7 Serotonin and the neurobiology of anxious states
    Adam J. Lawther, Matthew W. Hale, and Christopher A. Lowry
    4.8 Dorsal raphe serotonergic neurons regulate behavior on multiple timescales
    Jeremiah Y. Cohen and Cooper D. Grossman
    4.9 The role of central serotonin in impulsivity, compulsivity and decision-making: Comparative studies in experimental animals and humans
    B.U. Phillips and T.W. Robbins
    4.10 The role of serotonin in learning and memory: a rich pallet of experimental studies
    Jean-Christophe Cassel
    4.11 The role of serotonin in performance monitoring and cognitive control
    Adrian G Fischer and Gerhard Jocham
    4.12 Serotonin and 5-HT2B receptors in microglia control of behavior
    Ivana D'Andrea, Catherine Béchade, and Luc Maroteaux
    4.13 The serotonin-free brain: behavioural consequences of Tph2 deficiency in animal models
    Valentina Mosienko, Michael Bader, and Natalia Alenina

    Section 5: Serotonin in psychiatric disorders
    5.1 Serotonin in panic and anxiety disorders
    Hélio Zangrossi Jr., Cristina Marta Del Ben, Frederico Guilherme Graeff, and Francisco Silveira Guimarães 5.2 Serotonin and aggression – An update
    Isabel M. Quadros, Aki Takahashi, and Klaus A. Miczek
    5.3 Revisiting the Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression
    Olivia F. O’Leary, Martin G. Codagnone, and John F. Cryan
    5.4 Serotonin and schizophrenia
    Boris B. Quednow, Mark A. Geyer, and Adam L. Halberstadt
    5.5 Serotonin neurobiology in cocaine use disorder
    Kathryn A. Cunningham, Leonard L. Howell, and Noelle C. Anastasio
    5.6 The role of serotonin in alcohol use and abuse
    Christian P. Müller, Gunter Schumann, Johannes Kornhuber, and Liubov S. Kalinichenko
    5.7 The role of serotonin in nicotine abuse and addiction
    Małgorzata Filip, Irena Smaga, and Edmund Przegaliński
    5.8 Serotonin and serotonin receptors in hallucinogen action
    Adam L. Halberstadt and David E. Nichols
    5.9 The serotonergic system in obsessive compulsive disorder
    Maik Derksen, Matthijs Feenstra, Ingo Willuhn, and Damiaan Denys
    5.10 Peripheral and central serotonin in the regulation of glucose metabolism
    Mireille J Serlie
    5.11 The role of serotonin in cortical development: implications for Autism Spectrum Disorder
    Christine F. Hohmann, Mary S. Lange, and Mary E. Blue
    5.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions
    Eva Friedel and Andreas Heinz
    5.13 Functional pharmacogenetics of serotonin receptors in psychiatric drug action
    Olga O. McGowan and Gavin P. Reynolds
    5.14 Classic psychedelics as therapeutics for psychiatric disorders
    Charles D. Nichols and Peter S. Hendricks

    Section 6: Serotonin in neurological disorders
    6.1 Serotonin in Parkinson's disease
    Zacharias Kohl and Jürgen Winkler
    6.2 Serotonin in seizures and epilepsy: a neurodevelopmental perspective
    Yuri Bozzi, Giacomo Maddaloni, and Massimo Pasqualetti
    6.3 Serotonin and stroke
    Jong S. Kim

Product details

  • No. of pages: 1042
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: January 21, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780444641250
  • eBook ISBN: 9780444641267

About the Series Volume Editors

Christian Muller

Dr. Müller is Professor of Addiction Medicine at the Friedrich-Alexander-University Erlangen-Nuremberg, Germany. He obtained his PhD in Psychology from the University of Düsseldorf. He did PostDocs at the University of Syracuse (USA), University of Düsseldorf, and University of Brasilia (Brazil) before becoming a Senior Lecturer at the Institute of Psychiatry, King’s College London, UK. In 2010 he joined the Friedrich-Alexander-University of Erlangen-Nuremberg, Germany. He serves on several journal editorial boards and guest edited special issues of Behavioral Brain Research and Brain Research Bulletin. Dr. Müller has published more than 120 scientific papers and book chapters.

Affiliations and Expertise

Professor, Department of Psychiatry and Psychotherapy Friedrich-Alexander-University Erlangen-Nuremberg, Germany

Kathryn Cunningham

Kathryn A. Cunningham is a pharmacologist and neuroscientist with a focus on advancing the biological understanding of psychiatric disorders and developing effective and safe therapeutics to maximize human function. Her cross-disciplinary, translational research efforts with chemists, cell biologists and clinical scientists are focused on pinpointing the critical roles of two serotonin proteins (5-HT2A and 5-HT2C receptors) in substance use disorder and the discovery of novel medications to extend abstinence. Her research has been funded continuously for 26 years, has led to three patents for new chemical entities and over 150 publications. Her research and educational contributions have been recognized by the American Society for Pharmacology and Experimental Therapeutics-Astellas Award for Translational Pharmacology and the Marian Fischman Memorial Award and the Mentorship Award from the College on Problems of Drug Dependence. Dr. Cunningham is the author of nearly 150 scientific publications and is currently Associate Editor of ACS Chemical Neuroscience and of Nature Neuropsychopharmacology.

Affiliations and Expertise

Professor, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, USA

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