Handbook of the Behavioral Neurobiology of Serotonin

Handbook of the Behavioral Neurobiology of Serotonin

1st Edition - December 2, 2009

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  • Editors: Christian Muller, Barry Jacobs
  • eBook ISBN: 9780080878171
  • Hardcover ISBN: 9780123746344

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Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.

Key Features

  • The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system
  • Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others
  • The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community
  • Of great value not only for researchers and experts, but also for students and clinicians as a background reference


neuroscientists, pharmacologists, psychiatrists, neurologists and psychologists in academia, medical institutions, pharmaceutical industry.
Level: Graduate student and up. Suited for advanced courses in behavioral genetics, behavioral pharmacology, behavioral neuroscience and psychiatry as a reference and supplementary reading material (particularly the on-line version will be useful).

Table of Contents

  • Section 1: Functional anatomy of the serotonergic system

      1. Evolution of serotonin: sunlight to suicide
      2. Efrain C. Azmitia

      3. Genetic organisation of the serotonergic system
      4. Ursula M. D’Souza and Ian W. Craig

      5. The neuronatomy of the serotonergic system
      6. Jean-Pierre Hornung

      7. Ultrastructure of the serotonin innervation in mammalian central nervous system
      8. Laurent Descarries Mustapha Riad and Martin Parent

      9. Classification and signaling characteristics of 5-HT receptors
      10. Joël Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin

      11. Distribution of 5-HT receptors in the central nervous system
      12. Guadalupe Mengod, Roser Cortés, M. Teresa Vilaró and Daniel Hoyer

      13. Measuring serotonin activity in vivo in the brains of animals and humans

    Charles A Marsden

    Section 2: The neurophysiology of serotonin

    2.1 Activity of brain serotonergic neurons in relation to physiology and behavior

    Barry L. Jacobs and Casimir A. Fornal

    2.2 Electrophysiology of serotonin receptors

    Gerard J. Marek

    2.3 Tryptophane hydroxylase and serotonin synthesis regulation

    Hiroyuki Hasegawa and Kazuhiro Nakamura

    2.4 The degradation of serotonin: role of MAO

    Marco Bortolato, Kevin Chen and Jean C Shih

    2.5 Cellular effects of serotonin in the CNS

    Rodrigo Andrade and Sheryl G. Beck

    2.6 Serotonergic feedback control

    Trevor Sharp

    2.7 Tryptophan depletion and serotonin release - a critical reappraisal

    Matthijs G.P. Feenstra and Geoffrey van der Plasse

    2.8 Serotonin interaction with other transmitter systems

    Albert Adell, Analía Bortolozzi, Llorenç Díaz-Mataix, Noemí Santana, Pau Celada, and Francesc Artigas

    2.9 Serotonergic regulation of rhythmical activity of the brain, concentrating on the hippocampus

    Robert P. Vertes

    2.10 5-HT neurons and central CO2 chemoreception

    Carolin I. Dohle and George B. Richerson

    Section 3: Serotonin and behavioural control

    3.1 Serotonin and development

    Patricia M. Whitaker-Azmitia

    3.2 Serotonin and basal sensory: motor control

    Robert J. Carey

    3.3 Role of the serotonergic system in appetite and ingestion control

    Michelle D. Lee and Peter G. Clifton

    3.4 Serotonin and sexual behavior

    Lynda Uphouse and Jutatip Guptarak

    3.5 Serotonin in mood and emotion

    Julie G. Hensler

    3.6 Serotonin and the neurobiology of anxious states

    Christopher A. Lowry and Matthew W. Hale

    3.7 Role of Serotonin in Brain Reward and Regulation of Alcohol Drinking Behavior

    W. J. McBride

    3.8 Role of central serotonin in impulsivity and compulsivity: Comparative studies in experimental animals and humans

    TW Robbins & MJ Crockett

    3.9 Experimental studies on the role(s) of serotonin in learning and memory functions

    Jean-Christophe Cassel

    3.10 Social behavior and serotonin

    Elif Aysimi Duman and Turhan Canli

    3.11 Serotonin in pain and pain control

    Claudia Sommer

    Section 4: Serotonin in disease conditions

    4.1 The Impact of Stress on Serotonergic Neurotransmission

    Astrid C.E. Linthorst and Johannes M.H.M. Reul


    4.2 Role for serotonin in depression

    Gregory V. Carr and Irwin Lucki

    4.3 The role of serotonin in drug addiction

    Christian P. Müller, Martin E. Pum, Gunter Schumann and Joseph P. Huston

    4.4 The serotonergic system in obsessive compulsive disorders

    Addy van Dijk, Andre Klompmakers, and Damiaan Denys

    4.5 The role of serotonin in attention-deficit hyperactivity disorder (ADHD)

    Robert D. Oades

    4.6 Serotonin and schizophrenia

    Boris B. Quednow, Mark A. Geyer, and Adam L. Halberstadt

    4.7 Serotonin and serotonin receptors in hallucinogen action

    Adam L. Halberstadt and David E. Nichols

    4.8 The role of serotonin in cortical development: implications for Autism Spectrum Disorder [ASD]

    Christine F. Hohmann and Mary E. Blue

    4.9 Serotonin in panic and anxiety disorders

    Francisco Silveira Guimarães, Hélio Zangrossi Jr., Cristina Marta Del Ben and Frederico Guilherme Graeff

    4.10 Serotonin and agression

    Isabel M. Quadros, Aki Takahashi and Klaus A. Miczek

    4.11 Altered serotonin function in anorexia and bulimia nervosa

    Vikas Duvvuri, Ursula F Bailer and Walter H Kaye

    4.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions

    Eva Friedel & Andreas Heinz

    4.13 The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression

    Olivia F. O’Leary and John F. Cryan

    4.14 Functional pharmacogenetics of serotonin receptors in psychiatric drug action

    Olga O. Yevtushenko, Gavin P. Reynolds


Product details

  • No. of pages: 836
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: December 2, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080878171
  • Hardcover ISBN: 9780123746344

About the Editors

Christian Muller

Dr. Müller is Professor of Addiction Medicine at the Friedrich-Alexander-University Erlangen-Nuremberg, Germany. He obtained his PhD in Psychology from the University of Düsseldorf. He did PostDocs at the University of Syracuse (USA), University of Düsseldorf, and University of Brasilia (Brazil) before becoming a Senior Lecturer at the Institute of Psychiatry, King’s College London, UK. In 2010 he joined the Friedrich-Alexander-University of Erlangen-Nuremberg, Germany. He serves on several journal editorial boards and guest edited special issues of Behavioral Brain Research and Brain Research Bulletin. Dr. Müller has published more than 120 scientific papers and book chapters.

Affiliations and Expertise

Professor, Department of Psychiatry and Psychotherapy Friedrich-Alexander-University Erlangen-Nuremberg, Germany

Barry Jacobs

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