Handbook of the Behavioral Neurobiology of Serotonin, Volume 21

1st Edition

Editors: Christian Muller Barry Jacobs
Hardcover ISBN: 9780123746344
eBook ISBN: 9780080878171
Imprint: Academic Press
Published Date: 2nd December 2009
Page Count: 836
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Table of Contents

Section 1: Functional anatomy of the serotonergic system

    1. Evolution of serotonin: sunlight to suicide
    2. Efrain C. Azmitia

    3. Genetic organisation of the serotonergic system
    4. Ursula M. D’Souza and Ian W. Craig

    5. The neuronatomy of the serotonergic system
    6. Jean-Pierre Hornung

    7. Ultrastructure of the serotonin innervation in mammalian central nervous system
    8. Laurent Descarries Mustapha Riad and Martin Parent

    9. Classification and signaling characteristics of 5-HT receptors
    10. Joël Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin

    11. Distribution of 5-HT receptors in the central nervous system
    12. Guadalupe Mengod, Roser Cortés, M. Teresa Vilaró and Daniel Hoyer

    13. Measuring serotonin activity in vivo in the brains of animals and humans

Charles A Marsden

Section 2: The neurophysiology of serotonin

2.1 Activity of brain serotonergic neurons in relation to physiology and behavior

Barry L. Jacobs and Casimir A. Fornal

2.2 Electrophysiology of serotonin receptors

Gerard J. Marek

2.3 Tryptophane hydroxylase and serotonin synthesis regulation

Hiroyuki Hasegawa and Kazuhiro Nakamura

2.4 The degradation of serotonin: role of MAO

Marco Bortolato, Kevin Chen and Jean C Shih

2.5 Cellular effects of serotonin in the CNS

Rodrigo Andrade and Sheryl G. Beck

2.6 Serotonergic feedback control

Trevor Sharp

2.7 Tryptophan depletion and serotonin release - a critical reappraisal

Matthijs G.P. Feenstra and Geoffrey van der Plasse

2.8 Serotonin interaction with other transmitter systems

Albert Adell, Analía Bortolozzi, Llorenç Díaz-Mataix, Noemí Santana, Pau Celada, and Francesc Artigas

2.9 Serotonergic regulation


Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.

The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.

This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have alre

Key Features

  • The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system
    Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others
    The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community.
    * Of great value not only for researchers and experts, but also for students and clinicians as a background reference.


neuroscientists, pharmacologists, psychiatrists, neurologists and psychologists in academia, medical institutions, pharmaceutical industry.
Level: Graduate student and up. Suited for advanced courses in behavioral genetics, behavioral pharmacology, behavioral neuroscience and psychiatry as a reference and supplementary reading material (particularly the on-line version will be useful).


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© Academic Press 2010
Academic Press
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"This book was overdue for a long time and I think that it has the chance to be a bestseller in this area."--Boris Quednow, Psychiatric Hospital, University Zurich, Switzerland

About the Editors

Christian Muller Editor

Barry Jacobs Editor