Section 1: Functional anatomy of the serotonergic system
- Evolution of serotonin: sunlight to suicide
- Genetic organisation of the serotonergic system
- The neuronatomy of the serotonergic system
- Ultrastructure of the serotonin innervation in mammalian central nervous system
- Classification and signaling characteristics of 5-HT receptors
- Distribution of 5-HT receptors in the central nervous system
- Measuring serotonin activity in vivo in the brains of animals and humans
Efrain C. Azmitia
Ursula M. D’Souza and Ian W. Craig
Laurent Descarries Mustapha Riad and Martin Parent
Joël Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin
Guadalupe Mengod, Roser Cortés, M. Teresa Vilaró and Daniel Hoyer
Charles A Marsden
Section 2: The neurophysiology of serotonin
2.1 Activity of brain serotonergic neurons in relation to physiology and behavior
Barry L. Jacobs and Casimir A. Fornal
2.2 Electrophysiology of serotonin receptors
Gerard J. Marek
2.3 Tryptophane hydroxylase and serotonin synthesis regulation
Hiroyuki Hasegawa and Kazuhiro Nakamura
2.4 The degradation of serotonin: role of MAO
Marco Bortolato, Kevin Chen and Jean C Shih
2.5 Cellular effects of serotonin in the CNS
Rodrigo Andrade and Sheryl G. Beck
2.6 Serotonergic feedback control
2.7 Tryptophan depletion and serotonin release - a critical reappraisal
Matthijs G.P. Feenstra and Geoffrey van der Plasse
2.8 Serotonin interaction with other transmitter systems
Albert Adell, Analía Bortolozzi, Llorenç Díaz-Mataix, Noemí Santana, Pau Celada, and Francesc Artigas
2.9 Serotonergic regulation
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.
This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have alre
- The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system
Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others
The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community.
* Of great value not only for researchers and experts, but also for students and clinicians as a background reference.
neuroscientists, pharmacologists, psychiatrists, neurologists and psychologists in academia, medical institutions, pharmaceutical industry.
Level: Graduate student and up. Suited for advanced courses in behavioral genetics, behavioral pharmacology, behavioral neuroscience and psychiatry as a reference and supplementary reading material (particularly the on-line version will be useful).
- No. of pages:
- © Academic Press 2010
- 2nd December 2009
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
"This book was overdue for a long time and I think that it has the chance to be a bestseller in this area."--Boris Quednow, Psychiatric Hospital, University Zurich, Switzerland