- Print ISBN 9780123859426
- Electronic ISBN 9780123859433
New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells and Cell Biology and Adult and Fetal Stem Cells, this work contains contributions from the world’s experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system.
VOLUME 1: Pluripotent Stem Cells
Chapter 1. Why Stem Cell Research? Advances in the Field
Chapter 2. “Stemness”: Definitions, Criteria, and Standards
What Is a Stem Cell?
Where Do Stem Cells Come From?
How are Stem Cells Identified, Isolated, and Characterized?
Stemness: Progress Toward a Molecular Definition of Stem Cells
Chapter 3. Pluripotential Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges
Biology of ES and ESL Cells
Stem Cell Therapy
Chapter 4. Embryonic Stem Cells in Perspective
Chapter 5. The Molecular Circuitry Underlying Pluripotency in Embryonic Stem Cells and iPS Cells
Signaling Networks Underlying Pluripotency
LIF and BMP Signaling Pathways Regulate Mouse ESC Self-Renewal
TGFβ and FGF Signaling Pathways Regulate Human ESC Self-Renewal
WNT Signaling is a Conserved Regulator of Pluripotency Across Species
Signaling Pathways Inhibit Differentiation and Converge on Core Transcriptional Circuitry to Maintain Pluripotency
Induced Pluripotency, Stochasticity, and Signaling Thresholds
Chapter 6. Molecular Organization of Cells
Molecules that Organize Cells
The EMT Transcriptional Program
Molecular Control of the EMT
Chapter 7. Stem Cell Niches
Stem Cell Niche Hypothesis
Stem Cell Niches in the Drosophila Germ Line
The Germ-Line Stem Cell Niche in the Drosophila Ovary
"The Handbook of Stem Cells, edited by Robert Lanza and colleagues, is an ambitious new text that achieves extraordinary completeness and inclusiveness...the editors have succeeded in putting together a reference that is broad enough in scope, but sufficiently detailed and rigorous, to be of real interest to both new and seasoned investigators in the field. ...In providing this treatise, which covers the history, biology, methods and applications of stem cells, the editors and authors have succeeded in establishing a conceptual framework and a common language for the field. In so doing, they have ensured that this two-volume set will serve as a benchmark reference in stem cell biology for years to come." --Nature Cell Biology, April 2005
"I am firmly convinced this is a set every biologist and physician, whatsoever his specialty, must have on his desk. ...The reader can benefit from the contributions by the foremost authorities and premiere names (more than 300 contributors; addresses provided) in the field of stem cell research. The two-volume collection of articles (155 chapters) covers everything of the present state of stem cell science, from the care and feeding of mouse stem cells to the possible use of embryonic stem cells in spinal cord repair." --European Journal of Histochemistry
"These books make an invaluable contribution to the education of researchers and clinicians both of the present day and of the future. They should be available in libraries of all biology and medical schools as well as those of companies and research institutions." --Ian Wilmut, Times Higher Education Supplement
"...a two volume collection of scientific articles covering everything from the care and feeding of mouse stems cells to the possible use of embryonic stem cells in spinal cord repairs. With 155 chapters and more than 300 contributors, the handbook is the result of a two