Handbook of Statistics, Volume 28

1st Edition

Bioinformatics in Human Health and Heredity

Series Volume Editors: C.R. Rao Ranajit Chakraborty Pranab Sen
Hardcover ISBN: 9780444518750
eBook ISBN: 9780080930985
Imprint: North Holland
Published Date: 30th August 2012
Page Count: 612
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Table of Contents

Editorial Board



Introduction: Wither Bioinformatics in Human Health and Heredity

1 Introduction

2 Sciences dealing with biological information and rationale of their integration

3 Goals and major research areas of bioinformatics

4 Why bioinformatics is so important and open areas of research

Bayesian Methods for Microarray Data

1 Introduction

2 Literature review

3 Hierarchical models for microarray analysis

4 Embryonic maize tissue development

5 Conclusion

6 Appendix

Statistical Analysis of Gene Expression Studies with Ordered Experimental Conditions

1 Introduction

2 “Short-series” time-course data

3 “Long series” time-course data for cyclic and developmental processes

4 Concluding remarks

Meta-Analysis of High Throughput Oncology Data

1 Introduction

2 Bayesian Networks

3 Example application in genetic epidemiology

4 Software and applications

5 Summary and future directions

A Statistical Appraisal of Biomarker Selection Methods Applicable to HIV/AIDS Research

1 Introduction

2 Biomarker definitions

3 HIV infection biomarker review

4 Statistical screening methods for biomarker selection

5 Causal inference approaches for biomarker selection

6 Targeted maximum likelihood estimation

7 Classifier performance assessed by ROC curve

8 Some impending statistical challenges

9 Multiplicity considerations in biomarker research

10 An application: hormonal contraception and HIV genital shedding and disease progression (GS study)

11 Discussion and conclusion

The Use of Hamming Distance in Bioinformatics

1 Introduction

2 Some diversity measures

3 U-statistics representation for the Hamming distance based measures in bioi


The field of statistics not only affects all areas of scientific activity, but also many other matters such as public policy. It is branching rapidly into so many different subjects that a series of handbooks is the only way of comprehensively presenting the various aspects of statistical methodology, applications, and recent developments.

The Handbook of Statistics, a series of self-contained reference books. Each volume is devoted to a particular topic in statistics with Volume 28 dealing with bioinformatics. Every chapter is written by prominent workers in the area to which the volume is devoted. The series is addressed to the entire community of statisticians and scientists in various disciplines who use statistical methodology in their work. At the same time, special emphasis is placed on applications-oriented techniques, with the applied statistician in mind as the primary audience.

Key Features

  • Comprehensively presents the various aspects of statistical methodology
  • Discusses a wide variety of diverse applications and recent developments
  • Contributors are internationally renowned experts in their respective areas


Statisticians and scientists in various disciplines who use statistical methodology in their work


No. of pages:
© North Holland 2012
North Holland
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About the Series Volume Editors

C.R. Rao Series Volume Editor

C. R. Rao, born in India, is one of this century's foremost statisticians, and received his education in statistics at the Indian Statistical Institute (ISI), Calcutta. He is Emeritus Holder of the Eberly Family Chair in Statistics at Penn State and Director of the Center for Multivariate Analysis. He has long been recognized as one of the world's top statisticians, and has been awarded 34 honorary doctorates from universities in 19 countries spanning 6 continents. His research has influenced not only statistics, but also the physical, social and natural sciences and engineering. In 2011 he was recipient of the Royal Statistical Society's Guy Medal in Gold which is awarded triennially to those "who are judged to have merited a signal mark of distinction by reason of their innovative contributions to the theory or application of statistics". It can be awarded both to fellows (members) of the Society and to non-fellows. Since its inception 120 years ago the Gold Medal has been awarded to 34 distinguished statisticians. The first medal was awarded to Charles Booth in 1892. Only two statisticians, H. Cramer (Norwegian) and J. Neyman (Polish), outside Great Britain were awarded the Gold medal and C. R. Rao is the first non-European and non-American to receive the award. Other awards he has received are the Gold Medal of Calcutta University, Wilks Medal of the American Statistical Association, Wilks Army Medal, Guy Medal in Silver of the Royal Statistical Society (UK), Megnadh Saha Medal and Srinivasa Ramanujan Medal of the Indian National Science Academy, J.C.Bose Gold Medal of Bose Institute and Mahalanobis Centenary Gold Medal of the Indian Science Congress, the Bhatnagar award of the Council of Scientific and Industrial Research, India and the Government of India honored him with the second highest civilian award, Padma Vibhushan, for “outstanding contributions to Science and Engineering / Statistics”, and also instituted a cash award in honor of C R Rao, “to b

Affiliations and Expertise

The Pennsylvania State University, University Park, PA, USA

Ranajit Chakraborty Series Volume Editor

Affiliations and Expertise

Director, Center for Computational Genomics Institute of Applied Genetics Professor, Department of Forensic and Investigative Genetics University of North Texas Health Science Center 3500 Camp Bowie Blvd., Fort Worth, Texas 76107

Pranab Sen Series Volume Editor

Pranab K. Sen is Cary C. Boshamer Professor of Biostatistics and Statistics at the University of North Carolina, and is a Fellow of the Institute of Mathematical Statistics and of the American Statistical Association. He is also an elected member of the International Statistical Institute.Prenab K. Sen is author or co-author of multiple volumes in Mathematical Statistics, Probability Theory and Biostatistics, and has published extensively in nonparametrics, multivariate and sequential analysis, and reliability and survival analysis.

Affiliations and Expertise

University of North Carolina, Chapel Hill, U.S.A.