Handbook of Proteolytic Enzymes, Volume 1

Handbook of Proteolytic Enzymes, Volume 1

2nd Edition - May 17, 2004

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  • Editors: Alan Barrett, J. Woessner, Neil Rawlings
  • eBook ISBN: 9780080984155

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Description

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Table of Contents


  • Editor Biographies

    Contributors

    Preface

    Introduction

    Abbreviations

    Aspartic Peptidases

    Introduction

    1 Aspartic Peptidases and their Clans

    2 Catalytic Pathway of Aspartic Peptidases

    Clan AA

    Family A1 3 Pepsin A

    4 Pepsin B

    5 Chymosin

    6 Cathepsin E

    7 Gastricsin

    8 Cathepsin D

    9 Napsin A

    10 Renin

    11 Mouse Submandibular Renin

    12 Memapsin 1

    13 Memapsin 2

    14 Plasmepsins

    15 Plasmepsin II

    16 Tick Heme-Binding Aspartic Proteinase

    17 Phytepsin

    18 Nepenthesin

    19 Saccharopepsin

    20 Neurosporapepsin

    21 Acrocylindropepsin

    22 Aspergillopepsin I

    23 Penicillopepsin

    24 Endothiapepsin

    25 Rhizopuspepsin

    26 Mucorpepsin

    27 Polyporopepsin

    28 Candidapepsin

    29 Candiparapsin

    30 Canditropsin

    31 Syncephapepsin

    32 Barrierpepsin

    33 Yapsin 1

    34 Yapsin 2

    35 Yapsin A

    36 Pregnancy-Associated Glycoproteins

    37 Pepsin F

    38 Rhodotorulapepsin

    39 Cladosporopepsin

    40 Pycnoporopepsin

    Family A2 and Others 41 Human Immunodeficiency Virus 1 Retropepsin

    42 Human Immunodeficiency Virus 2 Retropepsin

    43 Simian Immunodeficiency Virus Retropepsin

    44 Equine Infectious Anemia Virus Retropepsin

    45 Rous Sarcoma Virus Retropepsin and Avian Myeloblastosis Virus Retropepsin

    46 Human T-Cell Leukemia Virus Type I (HTLV-I) Retropepsin

    47 Bovine Leukemia Virus Retropepsin

    48 Mason-Pfizer Monkey Virus Retropepsin

    49 Mouse Mammary Tumor Virus Retropepsin

    50 Moloney Murine Leukemia Virus Retropepsin

    51 Feline Immunodeficiency Virus Retropepsin

    52 Human Retrovirus K10 Retropepsin

    53 Miscellaneous Viral Retropepsins

    54 Spumapepsins

    55 Fungal, Plant and Animal Retrotransposon Elements

    56 Cauliflower Mosaic Virus Proteinase

    Other Clans of Aspartic Peptidases

    57 Nodavirus Endopeptidase

    58 Signal Peptidase II

    59 Type IV Prepilin Peptidase

    60 Presenilins

    61 Omptin

    62 Plasminogen Activator of Yersinia Pestis

    63 Scytalidopepsin B

    64 Aspergillopepsin II

    65 Scytalidopepsin A

    66 Thermopsin

    Metallopeptidases

    Introduction

    67 Metallopeptidases and their Clans

    68 Catalytic Mechanisms for Metallopeptidases

    Clan MA Subclan E

    Family M1 69 Membrane Alanyl Aminopeptidase

    70 Aminopeptidase Ey

    71 Insect Aminopeptidase N

    72 Aminopeptidase A

    73 Pyroglutamyl-Peptidase II

    74 Cystinyl Aminopeptidase, Oxytocinase and Insulin-Regulated Aminopeptidase

    75 Aminopeptidase PILS

    76 Aminopeptidase PS

    77 Yeast Aminopeptidases Ape2, Aap1' and Yin7

    78 Lysyl Aminopeptidase (Bacteria)

    79 Aminopeptidase N (Streptomyces Lividans)

    80 Leukotriene A4 hydrolase

    81 Aminopeptidase B

    Family M2 82 Peptidyl-Dipeptidase A/Angiotensin I-Converting Enzyme

    83 Peptidyl-Dipeptidase A (Invertebrate)

    84 Angiotensin-Converting Enzyme

    Family M3 85 Thimet Oligopeptidase

    86 Neurolysin

    87 Saccharolysin

    88 Oligopeptidase A

    89 Peptidyl-Dipeptidase Dcp

    90 Mitochondrial Intermediate Peptidase

    91 Oligopeptidase F

    92 Oligopeptidase PepB

    93 Oligopeptidase MepB

    Families M4, M5 and M9 94 Thermolysin and Related Bacillus Metallopeptidases

    95 Lambda Toxin (Clostridium Perfringens)

    96 Aureolysin

    97 Listeria Metalloprotease Mp1

    98 Griselysin

    99 Coccolysin

    100 Pro-Aminopeptidase Processing Protease

    101 Vibriolysin

    102 Pseudolysin

    103 Legionella Metalloendopeptidase

    104 Vimelysin

    105 Mycolysin

    106 Vibrio Collagenase

    107 Clostridium Collagenases

    Family M13 108 Neprilysin

    109 Neprilysin-2

    110 Endothelin-Converting Enzyme 1

    111 Endothelin-Converting Enzyme 2

    112 Endothelin-Converting Enzyme-Like Peptidase 1

    113 PHEX Endopeptidase

    114 Kell Blood-Group Protein

    115 Neprilysin Homolog of Streptococci

    116 Oligopeptidase O

    Other Families in Subclan MA(E) 117 Tentoxylysin

    118 Bontoxilysins

    119 Hyicolysin

    120 Procollagen III N-Proteinase

    121 Ste24 Protease

    122 Mammalian Famesylated Protein-Converting Enzyme 1

    123 Baculovirus Enhancin

    124 Glycyl Aminopeptidase (Sphingomonas)

    Clan MA Subclan M

    Families M10 and M11 125 Collagenase 1

    126 Neutrophil Collagenase

    127 Collagenase 3

    128 Collagenase 4

    129 Gelatinase A

    130 Gelatinase B

    131 Stromelysin 1

    132 Stromelysin 2

    133 Stromelysin 3

    134 Matrilysin

    135 Matrilysin 2

    136 Macrophage Elastase

    137 Membrane-Type Matrix Metalloproteinase 1

    138 Membrane-Type Matrix Metalloproteinase 2

    139 Membrane-Type Matrix Metalloproteinase 3

    140 Membrane-Type Matrix Metalloproteinase 4

    141 Membrane-Type Matrix Metalloproteinase 5

    142 Membrane-Type Matrix Metalloproteinase 6

    143 RASI-1, MMP-19

    144 Enamelysin

    145 Matrix Metalloproteinase 21

    146 Chicken Matrix Metalloproteinase 22

    147 Matrix Metalloproteinase 23

    148 Epilysin

    149 Plant Matrixins

    150 Hydra Matrix Metalloproteinase (HMMP)

    151 Envelysin

    152 Serralysin and Related Enzymes

    153 Aeruginolysin

    154 Mirabilysin

    155 Epralysin

    156 Fragilysin

    157 Gametolysin

    Family M12 Subfamily A 158 Astacin

    159 Meprin A

    160 Meprin B

    161 Procollagen C-Endopeptidase

    162 Tolloid (Drosophila)

    163 Mammalian Tolloid-Like Peptidases

    164 Choriolysin L

    165 Choriolysin H

    166 Hydra Metalloproteinase 1 (HMP1)

    167 Flavastacin

    168 Other Astacin Homologs

    Family M12 Subfamily B 169 Brevilysin H6

    170 Acutolysin

    171 Bilitoxin

    172 Fibrolase

    173 Venom Metalloproteinases of Agkistrodon Contortrix Laticinctus

    174 Gloydius Halys Venom Metalloproteinases

    175 Leucolysin

    176 Bids Arietans Hemorrhagic Proteinases

    177 Bothrops Asper Hemorrhagic Proteinases

    178 Jararhagin

    179 Bothrolysin

    180 Bothropasin

    181 Jararafibrases II-IV of Bothrops Jararaca

    182 Basic Endopeptidases of Bothrops Moojeni Venom

    183 Kistomin

    184 Adamalysin

    185 Atrolysin A

    186 Atrolysin B

    187 Atrolysin C

    188 Atrolysin E

    189 Atrolysin F

    190 Atroxase

    191 Basilysin

    192 Horrilysin

    193 Ruberlysin

    194 Russellysin

    195 Carinactivase

    196 Multactivase

    197 Ecarin

    198 Mutalysins

    199 Najalysin

    200 Mocarhagin

    201 Ophiolysin

    202 Philodryas Venom Metalloproteinases

    203 Trimerelysin I

    204 Trimerelysin II

    205 Mucrolysin

    206 Lebetase

    207 ADAM Metalloproteinases

    208 ADAM9

    209 ADAM28, Mouse Form

    210 ADAM19

    211 Kuzbanian (Drosophila)

    212 ADAM12

    213 Tumor Necrosis Factor α-Converting Enzyme

    214 The ADAMTS Endopeptidases

    215 ADAMTS1

    216 Procollagen N-Endopeptidase, ADAMTS2

    217 Aggrecanases 1 and 2

    218 ADAMTS13: Von Willebrand Factor-Cleaving Protease

    219 ADAM10, Myelin-Associated Metalloendopeptidase

    Other Families in Clan MA 220 Pappalysin-1 (Pregnancy-Associated Plasma Protein-A)

    221 Immune Inhibitor A

    222 IgA Protease of Clostridium Ramosum

    223 Snapalysin

    224 Leishmanolysin

    225 BlaR1 and MecR1 Gene Products of Staphylococcus Aureus

    226 IgA-Specific Metalloendopeptidase

    227 Carboxypeptidase Taq

    228 Archaean Thermostable Carboxypeptidases

    229 Anthrax Lethal Factor

    230 Penicillolysin

    231 Deuterolysin

    232 Peptidyl-Lys Metalloendopeptidase

    233 Fungalysin

    234 FtsH Protease

    235 Mitochondrial m- and i-AAA Proteases

    236 Paraplegin

    237 FtsH Homolog in Chloroplasts

    238 Cytophagalysin

    239 Dipeptidyl-Peptidase III

    Clan MC

    240 Carboxypeptidase A

    241 Carboxypeptidase A2

    242 Carboxypeptidase U

    243 Mast Cell Carboxypeptidase

    244 Carboxypeptidase B

    245 Carboxypeptidase MeCPA

    246 Carboxypeptidase T

    247 Lysine Carboxypeptidase

    248 Carboxypeptidase E

    249 Carboxypeptidase Z

    250 Adipocyte-Enhancer Binding Unit 1

    251 Metallocarboxypeptidase D

    252 Carboxypeptidase M

    253 y-D-Glutamyl-(L)-Meso-Diaminopimelate Peptidase I

    Clan MD

    254 Zinc D-Ala-D-Ala Carboxypeptidase (Streptomyces)

    255 D-Ala-D-Ala Carboxypeptidase VanY

    256 VanX D-,D-Dipeptidase

    257 N-Acetylmuramoyl-L-Alanine Amidase

    Clan ME

    258 Pitrilysin

    259 Insulysin

    260 Nardilysin

    261 Axllp Gene Product (Saccharomyces Cerevisiae)

    262 Mitochondrial Processing Peptidase

    263 Chloroplast Stromal Processing Peptidase

    264 Metalloprotease 1

    265 Falcilysin

    266 Vaccinia Virus Metalloproteinase

    Clan MF

    267 Leucyl Aminopeptidase (Animal)

    268 Leucyl Aminopeptidase (Plant)

    269 Leucyl Aminopeptidase PepA

    270 Peptidase B (Escherichia Coli)

    Clan MG

    271 Methionyl Aminopeptidase Type 1

    272 Methionyl Aminopeptidase Type 2

    273 X-Pro Dipeptidase (Bacteria)

    274 X-Pro Dipeptidase (Eukaryotes)

    275 X-Pro Dipeptidase (Archaea)

    276 X-Pro Aminopeptidase (Prokaryote)

    277 X-Pro Aminopeptidase (Lactococcus)

    278 Aminopeptidase P1

    279 Aminopeptidase P2

    Clan MH

    280 Aspartyl Aminopeptidase

    281 Aminopeptidase I

    282 Glutamate Carboxypeptidase

    283 Peptidase T

    284 Peptidase V

    285 Gly-X Carboxypeptidase

    286 X-His Dipeptidase (Bacteria)

    287 Sulfolobus Carboxypeptidase

    288 Aminopeptidase Y

    289 Streptomyces Griseus Aminopeptidase

    290 Glutamate Carboxypeptidase II

    291 Vibrio Aminopeptidase

    292 Glutamyl Aminopeptidase (Lactococcus)

    293 Bacillus Aminopeptidase I

    294 N-Terminal Deblocking Aminopeptidase (Pyrococcus Furiosus)

    Other Clans of Metallopeptidases

    295 IadA β-Aspartyl Dipeptidase

    296 O-Sialoglycoprotein Endopeptidase

    297 Hydrogenase Maturation Endopeptidase

    298 Endopeptidase GPR

    299 S2P Protease

    300 Sporulation Factor SpoIVFB

    301 D-Aminopeptidase DppA

    302 Membrane Dipeptidase

    303 Dipeptidase AC (Acinetobacter)

    304 β-Lytic Metalloendopeptidase

    305 Staphylolysin

    306 Lysostaphin

    307 Aminopeptidase T

    308 PepS Gene Product (Streptococcus Thermophilus)

    Metallopeptidases not Yet Assigned to Families

    309 Tripeptide Aminopeptidase

    310 Clostridial Aminopeptidase

    311 X-Trp Aminopeptidase

    312 Tryptophanyl Aminopeptidase

    313 Aminopeptidase yscCo-II

    314 X-Arg Dipeptidase

    315 Met-X Dipeptidase

    316 Cytosol Nonspecific Dipeptidase

    317 X-His Dipeptidase

    318 β-Ala-His Dipeptidase

    319 Lysosomal Dipeptidase

    320 Peptidyl-Dipeptidase B

    321 Peptidyl-Dipeptidase (Streptomyces)

    322 Alanine Carboxypeptidase

    323 Membrane Pro-X Carboxypeptidase

    324 Carboxypeptidase G3

    325 Mitochondrial Carboxypeptidase

    326 Peptidyl-Asp Metalloendopeptidase

    327 Magnolysin

    328 Dactylysin

    329 Myxococcus Xanthus Metalloendopeptidase

    330 Dynorphin-Converting Enzyme

    Appendix 1 Organisms Mentioned in the Handbook

    Appendix 2 Suppliers Cited in the Handbook

    Index

Product details

  • No. of pages: 984
  • Language: English
  • Copyright: © Academic Press 2004
  • Published: May 17, 2004
  • Imprint: Academic Press
  • eBook ISBN: 9780080984155

About the Editors

Alan Barrett

Affiliations and Expertise

Wellcome Trust Sanger Institute, Cambridge, U.K.

J. Woessner

Affiliations and Expertise

University of Miami, Florida, U.S.A.

Neil Rawlings

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.

Affiliations and Expertise

Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK

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