Description

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by  pharmacogenomics and stratified medicine details.

Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

Key Features

  • Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise
  • Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics,  pharmacokinetics and pharmacodynamics
  • Covers newer technologies– next generation sequencing, proteomics, metabolomics
  • Provides information on animal models, lymphoblastoid cell lines, stem cells
  • Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues
  • Includes chapters on the global implications of pharmacogenomics

Readership

Clinical researchers across medical disciplines, genetics, molecular biology, molecular diagnostics, and genomic studies who are working on the various aspects of translational genetics and genomics; pharmacologists working with clinicians on these studies

Table of Contents

  • Dedication
  • Foreword
  • Preface
  • Acknowledgments
  • Part 1: Introduction
    • Chapter 1. Pharmacogenomics and Stratified Medicine
      • Abstract
      • 1.1 Overview
      • 1.2 The Genetic Basis of Drug Response and Adverse Effects
      • 1.3 Single-Gene Studies
      • 1.4 Genome-Wide Association Studies in Pharmacogenomics
      • 1.5 The Road to Personalization and Stratification
      • 1.6 Pharmacogenetic Biomarkers and Companion Diagnostics
      • 1.7 Economic Challenges
      • 1.8 Conclusions
      • References
  • Part 2: Basic Genetics
    • Chapter 2. Basic Genetics: The Cell, Mitosis and Meiosis, and Mendelian Laws
      • Abstract
      • Acknowledgments
      • 2.1 Overview of the Cell: Anatomy, Components, and Function
      • 2.2 Cell Reproduction: Cell Cycle and Mitosis
      • 2.3 Meiosis
      • 2.4 Mendelian Laws
      • 2.5 Public Databases for Biomedical Research in Humans
      • 2.6 Conclusion
      • Glossary
      • References
    • Chapter 3. The Human Genome, Gene Regulation, and Genomic Variation
      • Abstract
      • 3.1 Overview: Structure of the Human Genome
      • 3.2 Gene Structures
      • 3.3 Gene Expression
      • 3.4 Gene Regulation
      • 3.5 Genomic Variation
      • 3.6 Conclusion
      • References
    • Chapter 4. Epigenetics
      • Abstract
      • 4.1 Overview
      • 4.2 DNA Methylation
      • 4.3 Histones and Variants
      • 4.4 Epigenetic Disorders And Therapies
      • 4.5 Conclusion
      • References
  • Part 3: Experimental and Discovery Platforms
    • Chapter 5. Animal Models in Pharmacogenomics
      • Abstract
      • 5.1 Overview
      • 5.2 Rodent Models
      • 5.3 Nonrodent Models of Human Disease
      • 5.4 Genetic/Genomic Resources
      • 5.5 Ethical Issues of Animal Experimentation
      • 5.6 Caution and Limitations

Details

No. of pages:
1118
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123868831
Print ISBN:
9780123868824
Print ISBN:
9780128100523

Reviews

"…a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time."--Anticancer Research, January 2015

"This is an extremely useful resource for clinicians, scientists, or any individuals interested in an excellent review of the rapidly advancing field of pharmacogenomics and its increasing relevance for clinical practice. - Rating: 5 Stars"--Doody's.com, 03-Oct-14