Handbook of Oxidants and Antioxidants in Exercise

1st Edition

Editors: C. Sen L. Packer O. Hänninen
Hardcover ISBN: 9780444826503
eBook ISBN: 9780080538297
Imprint: Elsevier Science
Published Date: 16th February 2000
Page Count: 1220
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Interest in the science of exercise dates back to the time of ancient Greece. Today exercise is viewed not only as a leisurely activity but also as an effective preventive and therapeutic tool in medicine. Further biomedical studies in exercise physiology and biochemistry reports that strenuous physical exercise might cause oxidative lipid damage in various tissues. The generation of reactive oxygen species is elevated to a level that overwhelms the tissue antioxidant defense systems resulting in oxidative stress.

The Handbook of Oxidants and Antioxidants in Exercise examines the different aspects of exercise-induced oxidative stress, its management, and how reactive oxygen may affect the functional capacity of various vital organs and tissues. It includes key related issues such as analytical methods, environmental factors, nutrition, aging, organ function and several pathophysiological processes.

This timely publication will be of relevance to those in biomedical science and was designed to be readily understood by the general scientific audience.

Table of Contents


Part I: Introduction to free radicals. Free radical chemistry (K.-D. Asmus, M. Bonifačić).

Part II: Reactive species in tissues. Exercise and oxygen radical production by muscle (M.J. Jackson). Exercise and xanthine oxidase in the vasculature: superoxide and nitric oxide interactions (C.R. White et al.).

Part III: Oxidative stress: Mechanisms and manifestations. Chemical bases and biological relevance of protein oxidation (O. Tirosh, A.Z. Reznick). Lipid peroxidation in healthy and diseased models: influence of different types of exercise (H.M. Alessio). Metal binding agents: possible role in exercise (R.R. Jenkins, J. Beard). The role of xanthine oxidase in exercise (Y. Hellsten). Acute phase immune responses in exercise (J.G. Cannon, J.B. Blumberg). Oxidative DNA damage in exercise (A. Hartmann, A.M. Niess).

Part IV: Antioxidant defenses. Physiological antioxidants and exercise training (S.K. Powers, C.K. Sen). Superoxide dismutases in exercise and disease (K. Suzuki et al.). Antioxidants and physical exercise (C.K. Sen, A.H. Goldfarb).

Part V: Nutrition. Dietary sources and bioavailability of essential and nonessential antioxidants (E.A. Decker, P.M. Clarkson). Vitamin E (M.G. Traber).

Part VI: Cellular and molecular mechanisms. Biological thiols and redox regulation of cellular induced signaling (C.K. Sen). Regulation and deregulation of vascular smooth muscle


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© Elsevier Science 1999
Elsevier Science
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About the Editor

C. Sen

Affiliations and Expertise

University of California, Lawrence Berkeley National Laboratory, Biological Technologies EETD, Rm 251C, Mail Stop 3200, Life Sciences Addition, Bldg 20A, Berkeley, CA 94720-3200, USA

L. Packer

Affiliations and Expertise

University of California, Biological Technologies EETD, 251 Life Sciences Addition, Berkeley, CA 94720-3200, USA

O. Hänninen

Affiliations and Expertise

University of Kuopio, Department of Physiology, PO Box 1627, SF 70211 Kuopio, Finland


@from:R.J. Shephard @qu:...Most chapters contain detailed summary tables, and conclude with helpful lists of abbreviations. This will be a volume that many who are involved in exercise and applied physiology would like to own. @source:Canadian Journal of Applied Physiology @from:B. Halliwell @qu:...this is an excellent book that I recommend highly. Although some chapters do not mention exercise, this does not detract from their quality. @source:Free Radical Biology & Medicine