Handbook of Organic Name Reactions

Reagents, Mechanism and Applications

1st Edition - August 14, 2023
Authors: Dakeshwar Kumar Verma, Yeestdev Dewangan, Chandrabhan Verma
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 9 4 8 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 9 4 7 - 6

Handbook of Organic Named Reactions: Reagents, Mechanisms and Applications discusses the reactions used in organic synthesis, showing the value and scope of these reactions… Read more

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Handbook of Organic Named Reactions: Reagents, Mechanisms and Applications discusses the reactions used in organic synthesis, showing the value and scope of these reactions and how they are used in the synthesis of organic molecules. Presenting an accounting of the traditional methods used, as well as the latest details on the advances made in synthetic chemistry research, the named reactions of carbonyl compounds, alcohols, amines, heterocyclic molecules, rearrangements and coupling reactions are all included. Explaining the established research and including detailed mechanism information, step-by-step descriptions, problems and the applications of named reactions in industry, this book also discusses emerging aspects.

Additional sections cover present and future research directions, making it an invaluable resource for all those needing to familiarize themselves with the concepts and applications of designated reactions.

Cover image
Title page
Table of Contents
Copyright
Foreword
Preface
Chapter 1. Organic reaction mechanism
Abstract
1.1 Basics of organic chemistry
1.2 Reaction intermediates: carbocation, carbanion, free radical, carbene, nitrene, and benzyne
1.3 Nucleophilic addition to carbon-heteroatoms multiple bonds
1.4 Electrophilic addition to carbon-carbon multiple bonds
1.5 Nucleophilic aliphatic substitution and neighboring group participation
1.6 Unimolecular nucleophilic substitution (SN1)reaction
1.7 Bimolecular nucleophilic substitution (SN2)reaction
1.8 Neighbouring group participation (NGP)
1.9 Substitution nucleophilic internal (SNi) Mechanism
1.10 Nucleophilic aromatic substitution
1.11 Electrophilic aliphatic, alkenyl, and alkynyl substitution reaction
1.12 Electrophilic aromatic substitution reaction
1.13 Elimination reaction
References
Chapter 2. Reactions of aldehydes and ketones
Abstract
2.1 Aldol condensation reaction
2.2 Baeyer–Villiger oxidation
2.3 Bamford–Stevens reaction
2.4 Barton decarboxylation reaction
2.5 Barbier reaction
2.6 Barbier in situ Grignard reaction
2.7 Baer–Fischer amino sugar synthesis
2.8 Baylis–Hillman reaction
2.9 Benzoin condensation
2.10 Bischler–Napieralski reaction
2.11 Bouveault–Blanc reduction reaction
2.12 Brown antialdol via B-enolate
2.13 Cannizzaro reaction
2.14 Claisen ester condensation
2.15 Clemmensen reduction reaction
2.16 Ciamician C=O photocoupling
2.17 Crimmins–Heathcock chiral anti-(syn) aldols
2.18 Cross-Cannizzaro reaction
2.19 Dakin reaction
2.20 Darzens reaction
2.21 De Mayo C=C photocycloaddition
2.22 Dieckmann condensation/cyclization reaction
2.23 Fujiwara arylation carboxylation
2.24 Gattermann aldehyde synthesis
2.25 Gattermann–Koch reaction
2.26 Haller–Bauer reaction
2.27 Haloform reaction
2.28 Hell–Volhard–Zelinsky reaction
2.29 Hunsdiecker reaction
2.30 Hollemann pinacol synthesis
2.31 Julia–Colonna asymmetric epoxidation
2.32 Knoevenagel reaction
2.33 Kiliani–Fischer sugar homologation
2.34 Mannich reaction
2.35 Meerwein–Ponndorf–Verley reduction reaction
2.36 Michael addition
2.37 Norrish type-I reaction
2.38 Norrish type-II reaction
2.39 Paterno–Buchi reaction
2.40 Perkin reaction
2.41 Peterson olefination
2.42 Reformatsky reaction
2.43 Riley selenium dioxide oxidation
2.44 Ruff–Fenton aldose degradation
2.45 Robinson annulation reaction
2.46 Rosenmund reaction
2.47 Shapiro reaction
2.48 Stobbe condensation reaction
2.49 Stork enamine alkylation
2.50 Tebbe reaction
2.51 Tishchenko reaction
2.52 Tollens reaction
2.53 Wittig reaction
2.54 Wolff–Kishner reduction
References
Further reading
Chapter 3. Reaction of alcohols
Abstract
3.1 Barton–McCombie deoxygenation
3.2 Baeyer–Villiger aromatic tritylation
3.3 Corey–Winter olefin synthesis
3.4 Corey–Chan synthesis
3.5 Gattermann synthesis reaction
3.6 Grieco olefination of alcohols
3.7 Houben–Hoesch reaction
3.8 Kolbe–Schmitt reaction
3.9 Mitsunobu reaction
3.10 Moffatt oxidation
3.11 Mukaiyama–Ueno oxidation
3.12 Reimer–Tiemann reaction
3.13 Ritter reaction
3.14 Swern oxidation reaction
3.15 Sharpless asymmetric epoxidation
3.16 Sharpless asymmetric dihydroxylation
3.17 Simmons–Smith cyclopropanation
References
Chapter 4. Reactions of heterocyclic compounds
Abstract
4.1 Algar–Flynn–Oyamada reaction
4.2 Bischler–Mohlau indole synthesis
4.3 Camps quinoline synthesis
4.4 Chichibabin reaction
4.5 Clauson–Kaas pyrrole synthesis
4.6 Combes quinoline synthesis
4.7 Dimroth triazole synthesis
4.8 Finnegan tetrazole synthesis
4.9 Fischer indole synthesis
4.10 Hantzsch pyrrole synthesis
4.11 Hantzsch thiazole synthesis
4.12 Knorr pyrrole synthesis
4.13 MacDonald porphyrin synthesis
4.14 Madelung indole synthesis
4.15 Pfitzinger quinoline synthesis
4.16 Pomeranz–Fritsch–Schlitter isoquinoline synthesis
4.17 Reissert indole synthesis
4.18 Skraup synthesis
References
Chapter 5. Coupling reactions
Abstract
5.1 Buchwald–Hartwig coupling
5.2 Fukuyama thioester coupling
5.3 Furstner iron-catalyzed C=C coupling
5.4 Glaser–Sondheimer acetylene coupling
5.5 Hiyama coupling
5.6 Heck coupling
5.7 Knochel coupling
5.8 Kumada coupling
5.9 McMurry coupling
5.10 Negishi coupling
5.11 Sonogashira coupling
5.12 Stille coupling
5.13 Suzuki coupling
5.14 Castro–Stephens acetylene coupling
References
Chapter 6. Rearrangements, participation, and fragmentation reactions
Abstract
6.1 Arndt–Eistert homologation
6.2 Beckmann rearrangement
6.3 Benzidine rearrangement
6.4 Benzil-benzilic acid rearrangement
6.5 Brook rearrangement
6.6 Sigmatropic rearrangements
6.7 Carroll allyl β-ketoester rearrangement
6.8 Chan acyloxyacetic ester rearrangement
6.9 Curtius rearrangement
6.10 Demjanov diazonium rearrangement
6.11 Eschenmoser fragmentation reaction
6.12 Favorskii rearrangement
6.13 Fries rearrangement
6.14 Grob fragmentation
6.15 Hofmann rearrangement
6.16 Lossen rearrangement
6.17 Nazarov cyclization
6.18 Neber rearrangement
6.19 Photo-Fries rearrangement
6.20 Pschorr cyclization
6.21 Payne rearrangement
6.22 Semipinacol rearrangement
6.23 Schmidt rearrangement
6.24 Smiles rearrangement
6.25 Sommelet–Hauser rearrangement
6.26 Tiffeneau–Demjanov ring expansion
6.27 von Richter rearrangement
6.28 Wagner–Meerwein rearrangement
6.29 Wittig rearrangement
6.30 Wolff rearrangement
6.31 Zimmerman Di-π methane rearrangement
References
Chapter 7. Reaction of amines, carboxylic acid, and derivatives
Abstract
7.1 Michaelis–Arbuzov reaction
7.2 Buchwald–Hartwig amination
7.3 Chugaev reaction
7.4 Darapsky amino acid synthesis
7.5 Erlenmeyer–Bergmann amino acid synthesis
7.6 Eschenmoser–Tanabe fragmentation
7.7 Gabriel synthesis
7.8 Hofmann elimination reaction
7.9 Prelog–Stoll acyloin condensation
7.10 Sandmeyer–Gattermann reaction
7.11 Strecker amino acid synthesis
7.12 Weinreb ketone synthesis
References
Chapter 8. Miscellaneous reactions
Abstract
8.1 Alder (Ene) Reaction
8.2 Anti-Markovnikov's Regioselectivity
8.3 Auwers Flavone Synthesis
8.4 Barton reaction
8.5 Borsche–Beech Synthesis
8.6 Balson reaction
8.7 Birch reduction
8.8 Click (Fokin) Synthesis
8.9 Diels alder reaction
8.10 Dakin–West Ketone Synthesis
8.11 Dutt–Wormall Azide Synthesis
8.12 Etard reaction
8.13 Felkin Cyclization
8.14 Fittig reaction
8.15 Gomberg –Bachmann reaction
8.16 Grubbs Olefin Metathesis
8.17 Hauser–Beak Ortho Lithiation
8.18 Kucherov–Deniges Hydration
8.19 Lemieux–Johnson reaction
8.20 Markovnikov's Regioselectivity
8.21 Nef reaction
8.22 Pauson–Khand Annulation
8.23 Petasis Titanocene Carbene Olefination
8.24 Peterson Olefination
8.25 Pfau–Plattner Synthesis
8.26 Simmons–Smith reaction (Simmons–Smith Cyclopropanation)
8.27 Staudinger Cycloaddition
8.28 Stork Radical Cyclization
8.29 Ullmann reaction
8.30 Williamson ether synthesis
8.31 Wurtz reaction
8.32 Wurtz-fittig reaction
References
Index

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Dakeshwar Kumar Verma

Yeestdev Dewangan

Chandrabhan Verma