Handbook of Nanosafety

1st Edition

Measurement, Exposure and Toxicology

Editors: Ulla Vogel Kai Savolainen Qinglan Wu Martie van Tongeren Derk Brouwer Markus Berges
Print ISBN: 9780128101247
eBook ISBN: 9780124166622
Imprint: Academic Press
Published Date: 2nd January 2014
Page Count: 376
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Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace.

Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM.

Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment.

Key Features

  • Multi-authored book, written by leading researchers in the field of nanotoxicology and nanosafety
  • Features state-of-the-art physical and chemical characterization of engineered nanomaterials (ENM)
  • Develops strategies for exposure assessment, risk assessment and risk management
  • Includes practical case studies and exposure scenarios to demonstrate how you can safely use ENM in the workplace


Toxicologists and scientists who work with ENM and aerosols. Occupational Toxicologists. Regulatory Toxicologists. Risk Assessors. Nanosafety managers. Industrial Hygienists

Table of Contents



List of Contributors


Chapter 1. General Introduction


1.1 Use and Applications of Engineered Nanomaterials

1.2 What is a Nanomaterial?

1.3 Exposure to Engineered Nanomaterials Merits Attention

1.4 How to Measure Exposure to Engineered Nanomaterials

1.5 How About the Hazards?

1.6 Requirements for the Assessment and Management of Risks of Engineered Nanomaterials

1.7 To be Expected in the Future

1.8 Conclusions


Chapter 2. Nanotechnology and Exposure Scenarios



2.1 Introduction

2.2 Development of Nanotechnology

2.3 Production of Engineered Nanomaterials

2.4 Applications of Nanotechnology

2.5 Exposure Scenarios for Nanomaterials

2.6 Exposure Scenario Case Examples

2.7 Summary


Chapter 3. Nanomaterials and Human Health


3.1 Introduction

3.2 Biokinetics, Cardiovascular and Neurotoxicity of Engineered Nanomaterials

3.3 Inflammatory Effects of Engineered Nanomaterials

3.4 Nanomaterial-Induced Pulmonary Inflammation

3.5 Nanomaterial-Induced Skin Inflammation

3.6 Genotoxicity of Engineered Nanomaterials

3.7 Carcinogenicity of Engineered Nanomaterials

3.8 Implications of Health Effects and Safety of Engineered Nanomaterials for Nanotechnologies

3.9 Conclusions


Chapter 4. From Source to Dose: Emission, Transport, Aerosol Dynamics and Dose Assessment for Workplace Aerosol Exposure


4.1 Sources of Nanoparticles in the Workplace (Seipenbusch)

4.2 Aerosol Dynamics in Workplace Atmospheres (Seipenbusch)

4.3 Modelling Approaches to Aerosol Dynamics and Transport in the Workplace (Yu)

4.4 Application


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Academic Press
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About the Editor

Ulla Vogel

Affiliations and Expertise

National Research Centre for the Working Environment, Copenhagen, Denmark

Kai Savolainen

Kai Savolainen is Research Professor, Nanosafety Research, at the Finnish Institute of Occupational Health. He obtained his Dr. Sci. degree in medicine and surgery from the University of Helsinki in 1981, and his Ph.D. degree in toxicology from the University of Kansas, USA, in 1987. His research covers inflammatory and genetic effects, and risk assessment of nanomaterials. He has served in numerous scientific expert committees, and has led several large research consortia on nanosafety. He also coordinates the EU NanoSafety Cluster, a platform of all EU FP-funded nanosafety projects.

Affiliations and Expertise

Ph.D. Nanosafety Research Center Finnish Institute of Occupational Health

Qinglan Wu

Martie van Tongeren

Derk Brouwer

Markus Berges


"Most of the information is from the NANODEVICE research project funded by the European Union, but the findings often integrate results of other research as well. Contributors from a wide range of sciences cover nanotechnology and exposure scenarios; nanomaterials and human health…"--ProtoView.com, April 2014