Handbook of in Vivo Neural Plasticity Techniques - 1st Edition - ISBN: 9780128120286

Handbook of in Vivo Neural Plasticity Techniques, Volume 28

1st Edition

A Systems Neuroscience Approach to the Neural Basis of Memory and Cognition

Series Volume Editors: Denise Manahan-Vaughan
Hardcover ISBN: 9780128120286
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 592
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Table of Contents

1. General Introduction – Denise Manahan-Vaughn, Ruhr University Bochum, Germany

The Rodent Hippocampus: Electrophysiological Approaches
2. Single-Unit Recordings in Rodents: Place Cells
3. Single Cell Recordings in Conjunction with Confocal Microscopy in Awake Rodents
4. Single Cell Recordings in Conjunction with Behavioral Analysis in Awake Rodents
5. Neuronal Oscillations in vivo (Spike Sorting and Multisite Recordings)
6. Recording Field Potentials and Synaptic Plasticity from Freely Behaving Rodents
7. Behaviorally Modulated LTP and LTD in vivo
8. Heterosynaptic Plasticity
9. Electrophysiology along the Ventral Hippocampal Axis
10. EEG Telemetry in Rodents

Cortical and Subcortical Structures: Electrophysiological Approaches
11. Single-Unit Recordings in Rodents: Grid Cells
12. Single-Unit Recordings in Rodents: Head Direction Cells
13. Voltage-Sensitive Dye Imaging in vivo
14. Optogenetic Manipulations in Conjunction with Electrophysiology
15. Sleep Electrophysiology in Rodents
16. Barrel Cortex
17. The Visual System (Cats)
18. The Visual System (Rodents)


Systems neuroscience comprises the empirical examination of brain function from the whole brain/whole animal perspective, and adopts the standpoint that without an examination of how brain systems interact in the living animal, we cannot fully understand the mechanisms that enable memory and cognition to occur. This field of neuroscience reflects a move away from the more traditional in vitro approaches to studying the mechanisms underlying brain plasticity. Instead, it integrates multifarious in vivo approaches with the goal of observing the emergence and subsequent implementation of cognitive representations and memory in behaving animals. Systems neuroscience reflects a fusion of established in vivo approaches that enable single-unit, field potential, or EEG recordings in behaving animals with novel methodologies such as optogenetics, virtual reality, activity-dependent genetic manipulations, and large-scale cellular imaging.

Handbook of Neural Plasticity gives a comprehensive overview of the current methods and approaches that are used to study neural plasticity from a systems neuroscience perspective. In addition, the book offers in-depth methodological advice that provides a necessary foundation for researchers who wish to establish these methods and for students who need to understand the theoretical and methodological bases of these approaches. This is the ideal resource for anyone new to the study of cognitive and behavioral neuroscience who needs an introduction to the state-of-the-art techniques used in relating physiology to behavior, as well as experts in in vitro techniques looking to transition to a systems-level approach.

Key Features

  • Offers a comprehensive overview of the state-of-the-art approaches to studying neuroplasticity in vivo
  • Combines discussion of the theoretical underpinnings for areas of investigation with the methodological and technical aspects necessary to guarantee success
  • Each chapter is arranged in a uniform format that clearly and concisely lays out descriptions, methods, and pitfalls of various techniques used in neural plasticity investigations


Advanced students and researchers in behavioral neuroscience, cognitive neuroscience, developmental neuroscience, neuropsychology, and the behavioral and cognitive sciences


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Academic Press
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About the Series Volume Editors

Denise Manahan-Vaughan Series Volume Editor

Prof. Dr. Denise Manahan-Vaughan is head of the Department of Neurophysiology, Dean of Studies and Director of the International Graduate School of Neuroscience, and Chair of the Research Department of Neuroscience of the Ruhr University Bochum. She has served as a member of the Executive Committee and Governing Council of the Federation of European Neuroscience Societies, and as speaker of the Competence Network for Neuroscience of the German Federal State of Northrhine Westphalia (NeuroNRW), and is currently speaker of the Collaborative Research Consortium on Integration and Representation of Sensory Processes (SFB 874), funded by the German Research Foundation. Her research focuses on characterization of hippocampal synaptic plasticity as a learning mechanism, primarily through investigations of two types of synaptic plasticity: long-term potentiation (LTP) and long-term depression (LTD). Her multidisciplinary approach incorporates in vivo electrophysiology in freely moving rodents with in vitro electrophysiology using the hippocampal slice preparation, as well as behavioral analysis of learning, confocal microscopy, immunohistochemical, biochemical and molecular biological analysis. On a physiological level, her research examines how synaptic plasticity, place cells and neuronal oscillations contribute to learning and how learning drives synaptic plasticity in health and disease; this work combines in vivo electrophysiology and EEG analysis with behavioral learning models and animal models of brain disorders. Manahan-Vaughan is the author of 130 scientific publications, and her findings regarding the role of hippocampal long-term depression in memory processing have contributed to a revised understanding of how synaptic plasticity may contribute to information encoding and memory.

Affiliations and Expertise

Chair, Department of Neurophysiology, Faculty of Medicine, Ruhr University Bochum, Germany