
Handbook of Diagnostic Endocrinology
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The clinical laboratory plays a critical role in the diagnosis and management of endocrine and related metabolic disorders, which are leading causes of morbidity and mortality in children and adults. The Handbook of Diagnostic Endocrinology, Third Edition, provides a ready reference for the evaluation, diagnosis, and monitoring of such disorders. This revision incorporates translational medicine, connecting what clinicians need to know with those in research providing a clinical context to which they can relate their molecular findings. This book solves the needs of clinicians and researchers by bringing together in one book endocrinology at the molecular and clinical levels. As the intricacies of intracellular signaling have become better understood, states of hormone resistance are now increasingly recognized. The most common endocrinopathy in westernized countries, the metabolic syndrome, results, to a large extent, from insulin resistance. The complexity of the circulating forms of various hormones are acknowledged in this revision.
Key Features
- Each chapter focuses on the biochemical tests that are required, either in the basal state or following provocation or suppression, to assist in the diagnosis of the various disorders
- Describes proper sample collection and relevant interpretations of laboratory tests
- Contains essential molecular biology and incorporates it with the clinical information
- Includes the discovery of new diagnostic and treatment methods
Readership
Clinical chemists, chemical pathologists, endocrinologists, and senior medical technologists to aid them in the investigation of endocrine and metabolic disorders
Table of Contents
- 1. Maximizing the value of laboratory tests
Raffick A.R. Bowen, Roger L. Bertholf and Brett Holmquist
2. Laboratory investigation of disorders of the pituitary gland
Verena Gounden, Charlotte C. Ellberg and Ishwarlal Jialal
3. Thyroid disease and laboratory assessment
Sridevi Devaraj and Emily Garnett
4. Disorders of the adrenal gland
Roger L. Bertholf
5. Endocrine disorders of the reproductive system
Angela M. Ferguson and Mark A. Cervinski
6. Gastroenteropancreatic tumors
Neeraj Ramarishnan, Seong Hyun Ahn and Ishwarlal Jialal
7. Evaluation of hypoglycemia
William E. Winter and Neil S. Harris
8. Evaluation of hyperglycemia
William E. Winter, David L. Pittman, Sridevi Devaraj, Danni Li and Neil S. Harris
9. Lipoproteins
Anna Wolska and Alan T. Remaley
10. Disorders of calcium metabolism
William E. Winter and Neil S. Harris
11. Laboratory evaluation of endocrine hypertension
William E. Winter and Neil S. Harris
12. Malignancy-associated endocrine disorders
Lori J. Sokoll and Daniel W. Chan
13. Laboratory assessment of acquired immunodeficiency syndrome endocrinopathies
Verena Gounden and Manisha Chandalia
14. Laboratory evaluation of short stature in children
William E. Winter
15. Pregnancy and the fetus
K. Aaron Geno, Mark A. Cervinski and Robert D. Nerenz
16. Disorders of sexual development
William E. Winter, Paul Hiers and Dina N. Greene
17. Transgender endocrinology
Dina N. Greene, Tamar Reisman and Zil Goldstein
18. The endocrinology of aging
Daniel T. Holmes and Gregory Kline
Product details
- No. of pages: 744
- Language: English
- Copyright: © Academic Press 2020
- Published: October 3, 2020
- Imprint: Academic Press
- eBook ISBN: 9780128182789
- Paperback ISBN: 9780128182772
About the Editors
William Winter
A native of San Francisco, Dr. Winter attended Santa Clara University as an undergraduate majoring in chemistry. After medical school at Loyola University of Chicago, Dr. Winter trained in pediatrics at the University of Kentucky followed by training in pediatric endocrinology at the University of Florida. Dr. Winter is Professor of Pathology, Immunology and Laboratory Medicine; Pediatrics; and Molecular Genetics and Microbiology at the University of Florida in Gainesville, Florida. Dr. Winter holds boards in Pediatrics, Pediatric Endocrinology and Chemical Pathology. He is a diplomat of the American Board of Clinical Chemistry (DABCC), a fellow of the American Association for Clinical Chemistry Academy (FAACC) and is a fellow of the College of American Pathologists (FCAP). Between 1993 and 2006 he served as Medical Director for clinical chemistry at Shands Hospital at the University Florida. He also served as the pathology residency program director from 1992-1996 and 1998-2004. In addition to his current duties as a staff clinical chemist, he is principle investigator for the NIH-funded Type 1 Diabetes TrialNet Islet Cell Autoantibody Core Laboratory and the NIH-funded Islet Autoantibody Standardization Program (IASP). Dr. Winter directs the Endocrine Autoantibody Laboratory that is part of the University of Florida Health Pathology Laboratories (UFHPL). Dr. Winter's specialties are clinical chemistry and pediatric endocrinology. He teaches in the basic science and clinical science curricula of the UF College of Medicine and directs the pathology course for UF dental students.A native of San Francisco, Dr. Winter attended Santa Clara University as an undergraduate majoring in chemistry. After medical school at Loyola University of Chicago, Dr. Winter trained in pediatrics at the University of Kentucky followed by training in pediatric endocrinology at the University of Florida. Dr. Winter is Professor of Pathology, Immunology and Laboratory Medicine; Pediatrics; and Molecular Genetics and Microbiology at the University of Florida in Gainesville, Florida. Dr. Winter holds boards in Pediatrics, Pediatric Endocrinology and Chemical Pathology. He is a diplomat of the American Board of Clinical Chemistry (DABCC), a fellow of the American Association for Clinical Chemistry Academy (FAACC) and is a fellow of the College of American Pathologists (FCAP). Between 1993 and 2006 he served as Medical Director for clinical chemistry at Shands Hospital at the University Florida. He also served as the pathology residency program director from 1992-1996 and 1998-2004. In addition to his current duties as a staff clinical chemist, he is principle investigator for the NIH-funded Type 1 Diabetes TrialNet Islet Cell Autoantibody Core Laboratory and the NIH-funded Islet Autoantibody Standardization Program (IASP). Dr. Winter directs the Endocrine Autoantibody Laboratory that is part of the University of Florida Health Pathology Laboratories (UFHPL). Dr. Winter's specialties are clinical chemistry and pediatric endocrinology. He teaches in the basic science and clinical science curricula of the UF College of Medicine and directs the pathology course for UF dental students.
Affiliations and Expertise
Professor, Departments of Pathology, Immunology & Laboratory Medicine, Pediatrics, and Molecular Genetics and Microbiology; Principal Investigator, Type 1 Diabetes TrialNet ICA Core Laboratory; Director, UF Health Pathology Laboratories, Endocrine Autoantibody Laboratory; Medical Director, Clinical Laboratory Support Services (CLSC)
Lori Sokoll
Lori J. Sokoll, Ph.D., FAACC is Professor of Pathology in the Johns Hopkins University School of Medicine and has secondary appointments in Oncology and Urology. She is Associate Director of the Clinical Chemistry Division and Director of the Special Chemistry Laboratory in the Johns Hopkins Hospital. Her research interests are focused on the evaluation and clinical applications of cancer biomarkers. She is an Associate Editor of the AACC publication Journal of Applied Laboratory Medicine.Lori J. Sokoll, Ph.D., FAACC is Professor of Pathology in the Johns Hopkins University School of Medicine and has secondary appointments in Oncology and Urology. She is Associate Director of the Clinical Chemistry Division and Director of the Special Chemistry Laboratory in the Johns Hopkins Hospital. Her research interests are focused on the evaluation and clinical applications of cancer biomarkers. She is an Associate Editor of the AACC publication Journal of Applied Laboratory Medicine.
Affiliations and Expertise
Professor of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Brett Holmquist
Dr Holmquist is board certified by the American Board of Clinical Chemistry, a fellow of the American Academy of Clinical Biochemistry, licensed by the state of California as a laboratory director, and certified as a New York State laboratory director. He earned his PhD in biochemistry and molecular biology from the University of California, Riverside. He has worked for more than 30 years in the life science industry, including more than 17 years in the diagnostic laboratory industry. He is a member of the Endocrine Society, the American Society for Mass Spectrometry and the American Association of Clinical Chemistry.
Affiliations and Expertise
Associate Vice President, Endocrine Sciences, Calabasas, CA, USA
Roger Bertholf
Roger L. Bertholf, PhD, is Medical Director of Clinical Chemistry at Houston Methodist Hospital, and Professor of Clinical Pathology and Laboratory Medicine at Weill Cornell Medical College. He has served as president of the Association of Clinical Scientists and the Academy of the American Association for Clinical Chemistry, and chaired the Florida Board of Clinical Laboratory Personnel. He received the Young Clinical Scientist Award, Clinical Scientist of the Year Award, and Diploma of Honor from the Association of Clinical Scientists, and the President’s Award from the American Society for Clinical Pathology. Bertholf is Editor in Chief of Laboratory Medicine.Roger L. Bertholf, PhD, is Medical Director of Clinical Chemistry at Houston Methodist Hospital, and Professor of Clinical Pathology and Laboratory Medicine at Weill Cornell Medical College. He has served as president of the Association of Clinical Scientists and the Academy of the American Association for Clinical Chemistry, and chaired the Florida Board of Clinical Laboratory Personnel. He received the Young Clinical Scientist Award, Clinical Scientist of the Year Award, and Diploma of Honor from the Association of Clinical Scientists, and the President’s Award from the American Society for Clinical Pathology. Bertholf is Editor in Chief of Laboratory Medicine.
Affiliations and Expertise
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA
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