Handbook of Brain Tumor Chemotherapy

Handbook of Brain Tumor Chemotherapy

1st Edition - December 13, 2005

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  • Editors: Herbert B. Newton, Herbert Newton
  • eBook ISBN: 9780080455938

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Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including “targeted” agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy.

Key Features

  • Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors
  • Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors
  • Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors


Neurosurgeons, neuro-oncologists, oncologists, neurologists, and oncological researchers with an interest in the development and application of chemotherapy to brain tumor patients.

Table of Contents

  • I. Pharmacology and Clinical Applications.
    1. Overview of Brain Tumor Epidemiology and Histopathology.
    2. Clinical Pharmacology of Brain Tumor Chemotherapy.
    3. Chemotherapy and Anti-Epileptic Drug Interactions.
    4. Brain Tumor Models for Cancer Therapy.
    5. Microarray Analysis and Proteomic Approaches to Drug Development.
    6. Chemotherapy Resistance.
    7. Clinical Trial Design and Implementation.

    II. Molecular Biology and Basic Science.
    8. Molecular Genetics of Brain Tumors - An Overview
    9. Regulation of the Cell Cycle and Interventional Developmental Therapeutics.
    10. Apoptosis Pathways and Chemotherapy.
    11. Growth Factor Signaling Pathways and Receptor Tyrosine Kinase Inhibitors.
    12. Ras Signaling Pathways and Farnesyl Transferase Inhibitors.
    13. PI3-Kinase, PKB/Akt, mTOR, and Internal Signaling Pathways.
    14. Tumor Invasiveness and Anti-invasion Strategies.
    15. Mechanisms of Angiogenesis in Brain Tumors and their Translation into Therapeutic Anti-tumor Strategies.
    16. Biology of the Blood-Brain and Blood-Brain Tumor Barriers.

    III. Innovative Approaches to Chemotherapy Delivery.
    17. Intra-Arterial Chemotherapy.
    18. Blood-Brain Barrier Disruption Chemotherapy.
    19. Interstitial Chemotherapy and Polymer-Drug Delivery.
    20. Intratumoral Administration and Convection-Enhanced Delivery.
    21. Marrow Ablative Chemotherapy with Hematopoietic Stem Cell Rescue.
    22. CSF Dissemination of Primary Brain Tumors.
    23. Chemotherapy-Activating Gene Therapy.

    IV. Chemotherapy of Specific Tumor Types.
    24. Chemotherapy of High-Grade Astrocytomas.
    25. Chemotherapy of Low-Grade Astrocytomas.
    26. Chemotherapy of Oligodendrogliomas.
    27. Chemotherapy of Oligoastrocytomas.
    28. Chemotherapy of Primary Central Nervous System Lymphomas.
    29. Chemotherapy of Medulloblastoma.
    30. Chemotherapy of Ependymoma.
    31. Chemotherapy of Glioneuronal Tumors.
    32. Chemotherapy of Pineal Parenchymal Tumors.
    33. Current Therapeutic Management Strategies for Primary Intracranial Germ Cell Tumors.
    34. Chemotherapy of Menigiomas.
    35. Chemotherapy for Brain Metasteses.
    36. The Role of Chemotherapy in Pediatric Gliomas.

Product details

  • No. of pages: 586
  • Language: English
  • Copyright: © Academic Press 2005
  • Published: December 13, 2005
  • Imprint: Academic Press
  • eBook ISBN: 9780080455938

About the Editors

Herbert B. Newton

Herbert B. Newton
Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years.

Affiliations and Expertise

Director, Neuro-Oncology Center, Medical Director, CNS Oncology Program, Advent Health Cancer Institute, Advent Health Orlando, Campus & Advent Health Medical Group, Professor of Neurology, UCF School of Medicine, Orlando, FL, USA

Herbert Newton

Affiliations and Expertise

Director, Division of Neuro-Oncology, Department of Neurology, Co-Director, Dardinger Neuro-Oncology Center, Ohio State University Medical Center, Columbus, Ohio, USA

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