Haematin Enzymes

Haematin Enzymes

A Symposium of the International Union of Biochemistry Organized by the Australian Academy of Science Canberra

1st Edition - January 1, 1961

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  • Editors: J. E. Falk, R. Lemberg, R. K. Morton
  • eBook ISBN: 9781483221496

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Description

International Union of Biochemistry, Volume 19: Haematin Enzymes, Part 1 provides information pertinent to the fundamental aspects of hematin enzymes. This book covers a variety of topics, including porphyrin complexes, chemical reactions of iron complexes, hemoprotein molecules, metalloporphyrins, and oxyhemoglobins. Organized into 22 chapters, this volume begins with an overview of the relevance of magnetic susceptabilitty and magnetic resonance data. This text then examines studies on electron-transfer processes involving metal ions and shows how the electronic structures of the hem enzymes may be relevant to the types of electron-transfer that can take place. Other chapters consider the implications of the coordination of organic molecules to metal ions. This book presents as well a comparison between known properties and reactions of some simple iron complexes with chelating and conjugated ligands. The final chapter deals with the chemical structures of the prosthetic groups of the cytochromes of type a. This book is a valuable resource for scientists, theorists, and research workers.

Table of Contents


  • Participants

    Presidential Address

    The Electronic Structure and Electron Transport Properties of Metal Ions Particularly in Porphyrin Complexes

    Discussion

    Terminology in Ligand-Field Theory

    Spin States of Haem Compounds

    Electron Transport

    Mechanism of Oxidative Phosphorylation

    The Role of the Metal in Porphyrin Complexes

    Discussion

    Higher Oxidation States

    Effects of Metal on Reactivity at Periphery

    The Physico-Chemical Behaviour of Porphyrins Solubilized in Aqueous Detergent Solutions

    Discussion

    Cations of Porphyrins and their Spectra

    The Reactions Between Metal Ions and Porphyrins

    Some Physical Properties and Chemical Reactions of Iron Complexes

    Discussion

    Oxidation-Reduction Potentials of Haem Compounds

    Spectra and Redox Potentials of Metalloporphyrins and Haemoproteins

    Discussion

    Correlations Between Structure and Physical Properties

    Models for Haemoproteins

    Some New Compounds of Haems with Bases

    Carbon Monoxide-Pyridine Complexes with Haems

    Equilibrium Constants for Reactions of Haems with Ligands

    Modification of the Secondary Structure of Haemoprotein Molecules

    Discussion

    The Haem-Binding Groups in Haemoproteins

    The Nature of Haem-Binding, and the Bohr Effect

    Models for Linked Ionizations in Haemoproteins

    On the Stability of Oxyhaemoglobin

    Discussion

    Oxygenation ofHaemoglobin

    Ferrihaemoprotein Hydroxides: A Correlation Between Magnetic and Spectroscopic Properties

    Discussion

    Spin States and Spectra of Haemoproteins

    The Electronic Origins of the Spectra

    Analysis and Interpretation of Absorption Spectra of Haemin Chromoproteins

    Discussion

    Interpretation of Absorption Spectra of Haemoproteins

    The Bands in the Region of 830 and 280 mμ

    The Haem-Globin Linkage. 3. The Relationship Between Molecular Structure and Physiological Activity of Haemoglobins

    Discussion

    Native Globin

    The Linkage of Iron and Protein in Haemoglobin

    Early Stages in the Metabolism of Iron

    The Enzymic Incorporation of Iron into Protoporphyrin

    Discussion

    The Formation of Metal-Porphyrin Complexes

    Co-Ordination of Divalent Metal Ions with Porphyrin Derivatives Related to Cytochrome c

    Metal Incorporation in Model Systems

    On the Enzymic Incorporation of Iron

    Biosynthesis and Metabolism of Cytochrome c

    The Location of Cytochromes in Escherichia coli

    Discussion

    The Origin ofthe Respiratory Granules of Bacteria

    On the Cytochromes of Anaerobically Cultured Yeast

    Discussion

    The Lactate Dehydrogenase of Yeast

    Components of the Respiratory Chain in Yeast Mitochondria

    On the 'Haemoglobin' Absorption Bands of Yeast

    Irreversible Inhibition of Catalase by the 3-Amino-1:2:4-Triazole Group of Inhibitors in the Presence of Catalase Donors

    Catalase Oxidation Mechanisms

    Discussion

    Oxidation States of Haemoproteins

    Peroxide Compounds of Catalase and Peroxidase

    The Nature of Catalase-Peroxide Complex I

    Studies on Problems of Cytochrome c Oxidase Assay

    Discussion

    Assay of Cytochrome c Oxidase

    Inhibition of Cytochrome c Oxidase by Cytochrome c

    Interaction of Cytochrome c with Other Compounds

    The Effect of Cations on the Reactivity of Cytochrome c in Heart Muscle Preparations

    Composition of Cytochrome c Oxidase

    Discussion

    Function of Copper in Cytochrome Oxidase Preparations

    Cytochrome Oxidases of Pseudomonas aeruginosa and Ox-Heart Muscle and their Related Respiratory Components

    Discussion

    Properties and Nomenclature of Cytochromes a and a3

    The Prosthetic Groups of Pseudomonas Cytochrome Oxidase

    The Reaction of Cytochrome c Oxidase with Oxygen

    The Oxygen-Reducing Equivalents of Cytochromes a and a3

    The Isolation, Purification and Properties of Haemin a

    Discussion

    Model Systems for Cytochrome Oxidase

    Absorption Spectra of Ferro- and Ferri-Compounds of Haem a

    Cryptohaem a

    Mitochrome in Relation to Cryptohaem a

    Cytochrome Oxidase Components

    The Structure of Porphyrin a, Cryptoporphyrin a and Chlorin a2

    Discussion

    The Structure of Haem a and Haem a2

    The Structure of Porphyrin a

    The Properties of Haem a2 and Cytochrome a2

    Extractability of Ferro- and Ferricytochrome c

    A Haemopeptide from a Tryptic Hydrolysate of Rhodospirillum rubrum Cytochrome c

    Electrometric and Other Studies on Cytochromes of the C-Group

    Discussion

    Protein Configuration and Linkage to the Prosthetic Group in Cytochrome c

    Studies of the Haemochrome-fonning Groups in Cytochrome c

    The Amino Acid Sequence in Horse Heart Cytochrome c

    Comments on the Structure of Cytochrome c

    Structure and General Properties of Cytochrome c

    Comparative Properties of Cytochrome c from Yeast and Heart Muscle

    Properties of Native Cytochrome c

    Reactivity of Native Cytochrome c in Oxidative Phosphorylation

    Structure of Bacterial Cytochromes of c-Type

    Structure and Redox Potentials of Cytochrome c

    The Electron Transfer from Cytochromes to Terminal Electron Acceptors in Nitrate Respiration and Sulphate Respiration

    Cytochrome C3

    Discussion

    Nature and Properties of Cytochrome c3

    Functional Aspects of Cytochrome c3

    Evolutionary Aspects of the Sulphate-Reducing Bacteria and of Cytochrome c3

    The Atypical Haemoprotein of Purple Photosynthetic Bacteria

    Discussion

    The Functions of Cytochrome b4 and of Cytochrome c544 (Halotolerant Coccus)

    Nomenclature of CO-Binding Pigments

    Cytochrome o

    On the Oxidase Function of RHP

    Spectrophotometric Studies of Cytochromes Cooled in Liquid Nitrogen

    Discussion

    'Trapped' Steady-States

    Low-Temperature Absorption Spectra of Cytochromes in Relation to Structure

    Studies on Microsomal Cytochromes and Related Substances

    Discussion

    On the Nature of Cytoplasmic Pigments of Liver Cells

    Possible Functions of the Cytochromes of the Endoplasmic Reticulum of Animal Cells

    The Significance of E0 Values of Cytochromes in Relation to Cellular Function

    The Cytochromes of Plant Tissues

    Discussion

    Cytochromes c1 and b3 of Particulate Components of Plants

    The Cytochromes of Roots

    The Chemical and Enzymic Properties of Cytochrome b2 of Bakers' Yeast

    Conditions for the Autoxidation of Flavocytochrome b2

    Kinetic Studies on the Action of Yeast Lactate Dehydrogenase

    Various Forms of Yeast Lactate Dehydrogenase

    Studies on Bakers' Yeast Lactate Dehydrogenase

    Discussion

    The Problem of Cytochrome b2

    Properties of Intact and Modified Cytochrome b2

    Nature of Bakers' Yeast Lactate Dehydrogenase

    Nomenclature of Cytochrome b2 and Derived Proteins

    The Substrate Specificity of Cytochrome b2

    On the Cytochrome b Components in the Respiratory Chain in Yeast

    The Kinetics of Reactions Catalysed by Cytochrome b2

    The Kinetics of Reduction of Cytochrome b2

    The Absorption Spectrum in Relation to the Structure of Cytochrome b2

    The Contribution of the Prosthetic Groups to the Absorption Spectrum of Cytochrome b2

    The Oxidation-Reduction Changes in the Reaction of Lactate with Cytochrome b2

    The Function and Bonding of the Flavin Group of Cytochrome b2

    The Bonding Between the Flavin Group and Apoprotein of Cytochrome b2

    Possible Free Radical Formation in Flavoproteins

    Autoxidation of Cytochrome b2

    The Role of Cytochrome b in the Respiratory Chain

    Discussion

    The Cross-Over Theorem and Sites of Oxidative Phosphorylation

    The Oxidation-Reduction Potential of Cytochrome b

    On the Redox Potential of Cytochrome b, the Kinetics of Reduction of Cytochrome b and the Existence of Slater's Factor

    The Influence of Cyanide on the Reactivity of Cytochrome b

    Energy Transfer and Conservation in the Respiratory Chain

    Discussion

    Mechanism of Oxidative Phosphorylation

    The Significance of Respiratory Chain Oxidations in Relation to Metabolic Pathways in the Cell

    Discussion

    On 'Additional DPN' of Incubated Mitochondria

    Possible Structure of Complexes of DPN or of DPNH Involved in Oxidative Phosphorylation

    Author Index

    Subject Index

Product details

  • No. of pages: 384
  • Language: English
  • Copyright: © Pergamon 1961
  • Published: January 1, 1961
  • Imprint: Pergamon
  • eBook ISBN: 9781483221496

About the Editors

J. E. Falk

R. Lemberg

R. K. Morton

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