Gynecologic and Obstetric Pathology, An Issue of Surgical Pathology Clinics

1st Edition, Volume 15-2 - June 19, 2022
Editor: Carlos Parra-Herran
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 4 9 8 7 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 4 9 8 8 - 3

In this issue of Surgical Pathology Clinics, guest editor Dr. Carlos Parra-Herran brings his considerable expertise to the topic of Gynecologic and Obstetric Pathology. Top experts… Read more

Gynecologic and Obstetric Pathology, An Issue of Surgical Pathology Clinics

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In this issue of Surgical Pathology Clinics, guest editor Dr. Carlos Parra-Herran brings his considerable expertise to the topic of Gynecologic and Obstetric Pathology. Top experts cover emerging topics in gynecologic pathology that are relevant to clinical practice, including information on classification, terminology, diagnostic criteria, and ancillary testing. This issues also includes a review of the pathologic findings in specimens from patients undergoing gender-affirming surgery.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Life After Amsterdam: Placental Pathology Consensus Recommendations and Beyond
Overview
Ascending intrauterine infection
Villitis of unknown etiology and related lesions
Maternal vascular malperfusion
Fetal vascular malperfusion
Placenta accreta spectrum
Placental infection by severe acute respiratory syndrome coronavirus 2
Summary
Clinics care points
Gestational Trophoblastic Disease: Contemporary Diagnostic Approach
Overview
Hydatidiform moles
Gestational trophoblastic tumors
Gestational choriocarcinoma
Epithelioid trophoblastic tumor
Placental site trophoblastic tumor
Clinics care points
Homologous Recombination Deficiency and Ovarian Cancer Treatment Decisions: Practical Implications for Pathologists for Tumor Typing and Reporting
Overview
Normal repair of double-strand breaks in DNA
Impaired homologous recombination repair
Exploiting HRD to treat pelvic high-grade serous carcinoma: synthetic lethality
Testing pelvic high-grade serous carcinoma for HRD
Homologous repair deficiency tests and FDA-approved PARP inhibitors
Role of the pathologist in HRD testing of ovarian cancer
Summary
Update on Ovarian Sex Cord–Stromal Tumors
Introduction
Pure stromal tumors
Pure sex cord tumors
Mixed sex cord–stromal tumors
Clinics care points
Peritoneal Pathology Review: Mullerian, Mucinous and Mesothelial Lesions
Endometriosis and related lesions
Endosalpingiosis
Pseudomyxoma peritonei and related ovarian/appendiceal pathology
Mesothelioma
Well-differentiated papillary mesothelial tumor (WDPMT)
Adenomatoid tumor
Prognosis
Clinics care points
Endometrial Cancer: An Update on Prognostic Pathologic Features and Clinically Relevant Biomarkers
Overview
Prognostic histologic features
Molecular classification of endometrial carcinoma
Theragnostic markers
Summary
Clinics care points
Uncommon and Difficult High-Grade Endometrial Carcinomas
Undifferentiated and dedifferentiated endometrial carcinoma
Mesonephric-Like Carcinoma of the Endometrium
Endometrial gastric-type carcinoma
Endometrial carcinoma with trophoblastic/germ cell-like components
Update on Uterine Mesenchymal Neoplasms
Overview
Epithelioid mesenchymal neoplasms
Myxoid mesenchymal neoplasms
Update on Mesenchymal Lesions of the Lower Female Genital Tract
Overview
Site-specific genital mesenchymal tumors
Non-site-specific mesenchymal lesions
Squamous and Glandular Epithelial Tumors of the Cervix: A Pragmatical Review Emphasizing Emerging Issues in Classification, Diagnosis, and Staging
Overview
Evolution in classification of cervical epithelial neoplasia
Invasive squamous cell carcinoma
Human papillomavirus-independent squamous cell carcinoma of the cervix
Human papillomavirus-not otherwise specified squamous cell carcinoma of the cervix
Invasive endocervical adenocarcinoma
Human papillomavirus-associated endocervical adenocarcinoma
Human papillomavirus-independent endocervical adenocarcinoma
Staging and prognostic factors issues and controversies in cervical carcinoma
Summary
Clinics care points
Squamous and Glandular Lesions of the Vulva and Vagina: What’s New and What Remains Unanswered?
Overview
Invasive squamous cell carcinoma
Clinical features
Microscopic evaluation & implications for patient care
Ancillary studies
Molecular findings & prognostication
In-situ squamous neoplasia
Glandular lesions of the vulva
Glandular lesions of the vagina
Summary
Clinics care points
Neuroendocrine Neoplasia of the Female Genital Tract
Overview
Terminology and classification of neuroendocrine neoplasia
Histogenesis and cell of origin of neuroendocrine neoplasia
Morphology of neuroendocrine neoplasia
Neuroendocrine carcinoma
Carcinoma admixed with neuroendocrine carcinoma
Immunohistochemistry of neuroendocrine neoplasia
Site-specific aspects of neuroendocrine neoplasia
Cytology of neuroendocrine neoplasia
Molecular pathology of neuroendocrine neoplasia
Clinical behavior of neuroendocrine neoplasia
Reproductive Organ Pathology of Individuals Undergoing Gender-Affirming Surgery
Background and considerations
Uterine cervix
Uterine corpus
Vagina
Vulva
Neovagina
Ovary
Fallopian tube
Breast/chest tissue (assigned female at birth [AFAB])
Breast/chest tissue (assigned male at birth [AMAB])
Testis
Prostate
Using gender-inclusive terminology in pathology reports