COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Gut Microbiome and Behavior - 1st Edition - ISBN: 9780128039496, 9780128039762

Gut Microbiome and Behavior, Volume 131

1st Edition

Serial Volume Editors: John F. Cryan Gerard Clarke
eBook ISBN: 9780128039762
Hardcover ISBN: 9780128039496
Imprint: Academic Press
Published Date: 25th October 2016
Page Count: 432
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Preface: The Gut Microbiome and Behavior under the microscope: Where to focus?

  • Setting the Stage
  • Brain Regions of Interest
  • Zooming in on the Gut Microbiome and Behavior at the Extremes of Life
  • The Gut Microbiome Though the Aperture of Stress
  • Resolving the Question of Mechanisms
  • Vision for the Future

Chapter One: Role of the Intestinal Microbiota in Host Responses to Stressor Exposure

  • Abstract
  • 1 Introduction
  • 2 Stress and the Stress Response
  • 3 Stressor Exposure and the Intestinal Microbiota
  • 4 Role of the Microbiota in the Body's Response to Stress
  • 5 Conclusions

Chapter Two: The Influence of Prebiotics on Neurobiology and Behavior

  • Abstract
  • 1 Introduction
  • 2 Prebiotics
  • 3 Neurobiological Changes Associated with Prebiotic Intake
  • 4 Prebiotic-Mediated Changes in Behavior
  • 5 Mechanistic Considerations
  • 6 Conclusion

Chapter Three: Gut Microbiome and Behavior: Focus on Neuroimmune Interactions

  • Abstract
  • 1 Microbiota–Brain Axis
  • 2 Microbiota and Immune Signaling Influence Behavior
  • 3 Probiotics Attenuate Stress- and Immune-Related Changes in Behavior
  • 4 Future Directions

Chapter Four: Neuropeptides, Microbiota, and Behavior

  • Abstract
  • 1 Neuropeptides Transcend Boundaries
  • 2 Signaling Pathways in Gut–Brain Communication
  • 3 Neurotransmitters and Neuropeptides in Gut Microbiota–Host Communication
  • 4 Microbiota Controls of the Availability of Amino Acids Required for Neuropeptide Synthesis
  • 5 Interaction of the Gut Microbiota with Neuroactive Gut Hormones
  • 6 Control of Neuropeptide Activity via Gut Microbiota-Dependent Autoantibodies
  • 7 Control of Peptide Signaling Through a Gut Microbiota–BBB Interaction
  • 8 Cerebral Neuropeptides Mediating the Impact of the Gut Microbiota on Brain Function and Behavior
  • 9 Conclusion: The Gut Microbiota–Neuropeptide Network
  • Acknowledgments

Chapter Five: Microbes and Oxytocin: Benefits for Host Physiology and Behavior

  • Abstract
  • 1 Introduction
  • 2 Oxytocin: A Multifunctional Neuropeptide
  • 3 Parallels Between Gut Bacteria and Oxytocin Effects
  • 4 Direct Evidence for Oxytocin-Depended Gut Bacteria Beneficial Effects
  • 5 Oxytocin and Gut Bacteria: An Advanced Quorum-Sensing Mechanism of Mammals?
  • 6 Probiotic Bacteria-Induced Endogenous Oxytocin for Therapy

Chapter Six: Intestinal Barrier and Behavior

  • Abstract
  • 1 The Intestinal Barrier: An Overview
  • 2 Can an Altered Barrier Function Disrupt Behavioral Responses?
  • 3 Stressors Affecting Both Behavior and Gut Barrier Function
  • 4 Concluding Remarks

Chapter Seven: Toxoplasma gondii—A Gastrointestinal Pathogen Associated with Human Brain Diseases

  • Abstract
  • 1 The Biology of Toxoplasma Infection
  • 2 Epidemiology of Toxoplasma Infection
  • 3 Chronic Toxoplasma Infection of Humans and Experimental Animals
  • 4 Toxoplasma Exposure and Neuropsychiatric Disorders
  • 5 Toxoplasma and Intestinal Inflammation
  • 6 Current Status of Anti-Toxoplasma Medications
  • 7 Ongoing Research Needs
  • 8 Conclusions

Chapter Eight: Exercise and Prebiotics Produce Stress Resistance: Converging Impacts on Stress-Protective and Butyrate-Producing Gut Bacteria

  • Abstract
  • 1 Stress and Health
  • 2 Gut Microbial Organisms and Their Metabolites Are Emerging Mediators of the Health Impacts of Stress
  • 3 Prebiotic Diets and Exercise Can Promote Stress-Protective Probiotic Bacteria
  • 4 Prebiotic Diets and Exercise Promote Resistance Against the Behavioral and Neurobiological Consequences of Inescapable Stress Through Unique and Overlapping Mechanisms
  • 5 The Stress-Protective Effects of Prebiotics and Exercise May Be Age Dependent

Chapter Nine: Circadian Rhythm and the Gut Microbiome

  • Abstract
  • 1 Circadian Rhythms in Health
  • 2 Circadian Rhythms in Disease
  • 3 Circadian Rhythms and the Intestinal Microbiota
  • 4 Conclusion

Chapter Ten: Sleep and Microbes

  • Abstract
  • 1 Introduction: History
  • 2 Sleep Physiology
  • 3 Bacterial Challenge Affects Sleep
  • 4 Sleep Loss Promotes Intestinal Bacterial Translocation
  • 5 Cecal Ligation
  • 6 Bacterial Components Driving Sleep Responses
  • 7 Sleep Responses to Virus Challenge
  • 8 Sleep Responses to Other Microbes
  • 9 Mechanisms
  • 10 Are Sleep Responses to Microbes Adaptive?
  • 11 Conclusions
  • Acknowledgments

Chapter Eleven: Cognitive Function and the Microbiome

  • Abstract
  • 1 Introduction
  • 2 Development of the Microbiota–Gut–Brain Axis
  • 3 Cognition in Gastroenterology
  • 4 Cognition in Extraintestinal Manifestations
  • 5 Microbiota and Cognition
  • 6 Probiotics and Cognition
  • 7 Future Directions
  • 8 Conclusions

Chapter Twelve: The Intestinal Microbiota in the Irritable Bowel Syndrome

  • Abstract
  • 1 Introduction
  • 2 The General Appeal of the Microbiota as Putative Pathogenetic Factor in IBS
  • 3 Factors Known to Precipitate or Exacerbate IBS also Induce Intestinal Dysbiosis
  • 4 Evidence of Dysbiosis in IBS Patients
  • 5 Proof of Principle that Intestinal Dysbiosis Alters Function in the Gut and Brain
  • 6 Future Directions

Chapter Thirteen: Gut-to-Brain Axis in Autism Spectrum Disorders: Central Role for the Microbiome

  • Abstract
  • 1 Introduction
  • 2 The Rodakis Case
  • 3 Microbiome in ASD: Correlation Studies
  • 4 From Correlation to Causation
  • 5 Possible Mechanisms of Microbiome–Brain Axis in Autism
  • 6 Conclusion

Chapter Fourteen: The Microbiome of the Built Environment and Human Behavior: Implications for Emotional Health and Well-Being in Postmodern Western Societies

  • Abstract
  • 1 Introduction
  • 2 Global Trends Toward Urbanization
  • 3 Shift in the Human Microbiome During the First and Second Epidemiological Transitions
  • 4 Differences Between the Microbiomes of the Outdoor Environment and the Built Environment
  • 5 The Microbiome of the Built Environment, Immunoregulation, and Human Behavior
  • 6 Inflammation Anergic Macrophages
  • 7 Regulatory Macrophages
  • 8 Urban Upbringing and City Living Affect Neural Social Stress Processing
  • 9 Conclusions

Chapter Fifteen: The Importance of Diet and Gut Health to the Treatment and Prevention of Mental Disorders

  • Abstract
  • 1 Introduction
  • 2 Diet and Mental Health Across the Lifespan
  • 3 The Importance of Diet for Gut Health Across the Lifespan
  • 4 Opportunities for Prevention and Treatment of Mental Health Disorders
  • 5 Conclusion


Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications.

Key Features

  • Contains the expertise of contributors in the field who discuss the gut microbiome and its effect on the brain and behavior
  • Defines the scope of the influence of the gut microbiome and the potential mechanisms and implications
  • Charts the way forward in this frontier area of research


Neuroscientists, Psychiatrists, Neurogastroenterologists, Microbiologists, Nutritionists, and researchers within developmental Biology and Medicine


No. of pages:
© Academic Press 2016
25th October 2016
Academic Press
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Serial Volume Editors

John F. Cryan

John F. Cryan

Professor Cryan is a professor at the Department of Anatomy and Neuroscience and APC Microbiome Institute, University College Cork, Cork, Ireland

Affiliations and Expertise

Alimentary Pharmabiotic Centre, University College Cork, Ireland

Gerard Clarke

Gerard Clarke

Professor Clark ia a professor at the Department of Psychiatry and Neurobehavioural Science and APC Microbiome Institute, University College Cork, Cork, Ireland

Affiliations and Expertise

Department of Psychiatry, University College Cork, Ireland