Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

1st Edition - July 12, 2011

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  • Author: Gajanan Sherbet
  • eBook ISBN: 9780123878205
  • Hardcover ISBN: 9780123878199

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Description

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment.

Key Features

  • Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes
  • Aids the development of therapeutic treatments for cancer
  • Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Readership

Developmental biologists, cell biologists and cancer researchers

Table of Contents

  • 1. Convergence of growth factor signalling pathways in developmental systems and pathogenesis
    2. Growth factor families
    3. TGF-β family growth factors in differentiation and morphogenesis
    4. Vascular endothelial growth factor
    5. The hepatocyte growth Factor
    6. The platelet derived growth factor family
    7. Nerve Growth Factors
    8. Insulin-like growth factors
    9. Connective tissue growth factor (CTGF)
    10. Thrombospondins
    11. Cytokines
    12. Growth factor and hedgehog signalling pathways meet in developmental systems
    13. Epidermal Growth Factors and their signalling systems
    14. Growth factors of the EGF family
    15. The fibroblast growth factor family
    16. Intracellular receptor binding growth factors
    17. Androgens and androgen receptors (AR) in development, differentiation and neoplasia
    18. Vitamin D3 in cell proliferation, apoptosis and differentiation
    19. Retinoids in development and pattern formation
    20. Oestrogens and progesterone in normal physiology and neoplasia
    21. Glucocorticoid signalling in normal and aberrant physiology

Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Elsevier 2011
  • Published: July 12, 2011
  • Imprint: Elsevier
  • eBook ISBN: 9780123878205
  • Hardcover ISBN: 9780123878199

About the Author

Gajanan Sherbet

Affiliations and Expertise

University of Newcastle upon Tyne, UK

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