GPI Membrane Anchors

GPI Membrane Anchors

1st Edition - May 22, 1992

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  • Editor: M Almeida
  • eBook ISBN: 9780323156097

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GPI Membrane Anchors reviews major advances in our understanding of glycosylphosphatidylinositol (GPI) membrane anchors. The book examines the GPI structure and its originality as an anchoring device, its ubiquitous distribution, the main steps of its biosynthetic pathway, and the elegant means by which a protein signals for GPI attachment. It also presents evidence for the uniqueness of GPI as a tag in intracellular traffic and as a mediator of transmembrane signaling. This volume is organized into 20 chapters and begins with a discussion of the structural requirements of a nascent protein for processing to a PI-G anchored form, with emphasis on experiments on intact cells and cell-free systems. It then turns to the mechanisms underlying signal transduction by GPI-anchored membrane proteins, the LY-6 superfamily of GPI-anchored molecules, and glycosylated-phosphatidylinositols as virulence factors in Leishmania. The reader is also introduced to the molecular biology of GPI-anchored border hydrolases, the role of GPIs and their inositolglycan derivatives in the mediation of insulin and growth factor function, and biosynthesis and cellular localization of GPI-modified glycoproteins in Saccharomyces cerevisiae. An account of electrospray mass spectrometry of a C-terminal peptide purified from the scrapie isoform of the scrapie prion protein is also given. The book concludes with a chapter on GPI-anchored recognition molecules that function in axonal fasciculation, growth, and guidance in the nervous system. This book is a valuable resource for students and researchers in the fields of cell biology and biochemistry.

Table of Contents

  • Contributors


    Structural requirements of a nascent protein for processing to a PI-G anchored form: studies in intact cells and cell-free systems

    Signal transduction by GPI-anchored membrane proteins

    Emergence of the LY-6 superfamily of GPI-anchored molecules

    Glycosylated-phosphatidylinositols as virulence factors in Leishmania

    Why do so many surface proteins of trypanosomatids have GPI-anchors?

    Probing the signal for glycophosphatidylinositol anchor attachment using decay accelerating factor as a model system

    Inositolglycans and cellular signalling

    Electrospray mass spectrometry of the glycosylinositol phospholipid of the scrapie prion protein

    Biosynthesis of glycophosphoinositol anchors in Saccharomyces cerevisiae

    Characterization of the plasma glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD)

    Evolutionary aspects of GPI metabolism in kinetoplastid parasites

    Biosynthesis of glycosyl-phosphatidylinositol

    Polarized sorting of GPI-linked proteins in epithelia and membrane microdomains

    Evaluation of somatic cell variants deficient in glycosylphosphatidyl-inositol anchoring as candidates for genetic correction

    Biochemical and functional characterization of a glycolipid anchored cell adhesion molecule in Dictyostelium discoideum

    The molecular biology of GPI-anchored border hydrolases

    The biology of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei

    Bacterial PIPLCs - unique properties and usefulness in studies on GPI anchors

    A chemical modification that makes glycoinositol phospholipids resistant to phospholipase C cleavage: fatty acid acylation of inositol

    Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system

Product details

  • No. of pages: 320
  • Language: English
  • Copyright: © Academic Press 1992
  • Published: May 22, 1992
  • Imprint: Academic Press
  • eBook ISBN: 9780323156097

About the Editor

M Almeida

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