Goodman's Basic Medical Endocrinology

Goodman's Basic Medical Endocrinology

5th Edition - February 21, 2021

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  • Authors: Elizabeth Holt, Beatrice Lupsa, Grace Lee, Hanan Bassyouni, Harry Peery
  • Hardcover ISBN: 9780128158449
  • eBook ISBN: 9780128158456

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Goodman's Basic Medical Endocrinology, Fifth Edition, has been student tested and approved for decades. This essential textbook provides up-to-date coverage of rapidly unfolding advances in the understanding of hormones involved in regulating most aspects of bodily functions. It is richly illustrated in full color with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. This is a classic reference for moving forward into advanced study.

Key Features

  • Clinical case studies in every chapter
  • E-book version available with every copy for obtaining images and tables for lectures or notes
  • Clinicians added as co-authors to enhance usefulness by physicians and medical students and residents
  • Detailed molecular biology of hormones and hormone action for graduate and advanced undergraduate students
  • Expanded and updated color images emphasizing hormone action at the molecular level
  • In-depth molecular biology and clinical sections boxed for ease of access


Upper division undergraduate and graduate students in biology, physiology, zoology; medical students; researchers and professionals in endocrinology. Biomedical researchers, graduate students, and fellows in the fields of endocrinology

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedications
  • Preface
  • Any screen. Any time. Anywhere
  • Chapter 1. Introduction
  • Abstract
  • Types of chemical messengers
  • Storage and release of hormones
  • Hormone transportation and fate
  • Hormone specificity
  • Hormone receptors
  • Desensitization and downregulation of G-protein-coupled receptors
  • Negative feedback
  • Positive feedback
  • Feed forward
  • Immunoassays
  • Radioimmunoassay
  • Immunometric assays
  • Suggested reading
  • Chapter 2. Pituitary gland
  • Abstract
  • Pituitary gland
  • Chapter 3. Thyroid gland
  • Abstract
  • Introduction
  • Morphology
  • Thyroid hormones
  • Control of thyroid function
  • Thyroid hormones in blood
  • Metabolism of thyroid hormones
  • Physiological effects of thyroid hormones
  • Regulation of thyroid hormone secretion
  • Mechanism of thyroid hormone action
  • Summary
  • Suggested readings
  • Chapter 4. The adrenal glands
  • Abstract
  • Adrenal glands
  • Anatomy and histology
  • Adrenal cortex
  • Physiology of the mineralocorticoids
  • Physiology of the glucocorticoids
  • Adrenal medulla
  • Suggested readings
  • Chapter 5. Principles of hormone integration
  • Abstract
  • Introduction
  • Integration of hormonal signals at the cellular and molecular level
  • Modulation of responding systems
  • Hormonal integration at the whole-body level
  • Summary
  • Suggested readings
  • Chapter 6. Hormones of the gastrointestinal tract
  • Abstract
  • Gastrointestinal hormones
  • Concluding comments
  • Suggested readings
  • Chapter 7. The pancreatic islets
  • Abstract
  • The pancreatic islets
  • Morphology of the endocrine pancreas
  • Glucagon
  • Insulin
  • Somatostatin
  • Summary
  • Suggested readings
  • Chapter 8. Hormonal regulation of fuel metabolism
  • Abstract
  • Hormonal regulation of fuel metabolism
  • General features of energy metabolism
  • Overall regulation of blood glucose concentration
  • Integrated actions of metabolic hormones
  • Regulation of metabolism during feeding and fasting
  • Hormonal interactions during exercise
  • Long-term regulation of fuel storage
  • Peripheral input to hypothalamic feeding and satiety neurons
  • Summary
  • Suggested readings
  • Chapter 9. Regulation of salt and water balance
  • Abstract
  • Introduction
  • Suggested reading
  • Chapter 10. Hormonal regulation of calcium balance
  • Abstract
  • Hormonal regulation of calcium balance
  • General features of calcium balance
  • Parathyroid glands and parathyroid hormone
  • Mechanisms of parathyroid hormone actions
  • Physiological actions of parathyroid hormone
  • Calcitonin
  • Vitamin D hormone
  • Calcium regulation of plasma calcium concentrations
  • Integrated actions of calciotropic hormones
  • Other hormones that influence calcium balance
  • Summary
  • References
  • Suggested readings
  • Chapter 11. Hormonal control of growth
  • Abstract
  • Hormonal control of growth
  • Effect of thyroid hormone on growth
  • Effect of insulin on growth
  • Effect of gonadal hormones on growth
  • Effect of glucocorticoids on growth
  • Summary
  • Suggested reading
  • Additional information
  • Chapter 12. Hormonal control of reproduction in the male
  • Abstract
  • Introduction
  • Sexual differentiation
  • Testes
  • Testosterone
  • Male reproductive development
  • Regulation of testicular function II
  • Summary
  • Oxytocin in the male
  • Suggested reading
  • Chapter 13. Hormonal control of reproduction in the female: the menstrual cycle
  • Abstract
  • Hormonal control of reproduction in the female: the menstrual cycle
  • Ovarian hormones
  • Control of ovarian function
  • Physiological actions of ovarian steroid hormones
  • Regulation of the reproductive cycle
  • Timing of reproductive cycles
  • Summary
  • Suggested readings
  • Chapter 14. Hormonal control of pregnancy and lactation
  • Abstract
  • Hormonal control of pregnancy and lactation
  • Fertilization and implantation
  • Respiratory adjustments
  • Summary
  • Suggested readings
  • Index

Product details

  • No. of pages: 552
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: February 21, 2021
  • Imprint: Elsevier
  • Hardcover ISBN: 9780128158449
  • eBook ISBN: 9780128158456

About the Authors

Elizabeth Holt

Dr. Holt is the co-director of the Yale Endocrine Neoplasia Group; past president of the Connecticut Endocrine Society; and has been recognized many times as a top doctor by Connecticut magazine.

Affiliations and Expertise

Associate Professor of Medicine, Endocrinology, Yale School of Medicine, New Haven, CT, United States

Beatrice Lupsa

Dr. Beatrice Lupsa is an Endocrinologist at Yale University School of Medicine in New Haven, Connecticut. She has a large academic clinical practice at the Yale Diabetes Center. Her clinical and academic interests include type 1 and type 2 diabetes mellitus, cardiovascular complications of diabetes, extreme forms of insulin resistance and lipodystrophy. Dr. Lupsa has expertise in continuous glucose monitoring systems, insulin pumps and in managing complicated diabetes cases. She is a dedicated clinician-educator training residents and fellows. She has authored many articles and book chapters and has been an invited reviewer for several endocrinology journals.

Affiliations and Expertise

Assistant Professor of Medicine, Endocrinology, Yale School of Medicine, New Haven, CT, United States

Grace Lee

Dr. Grace S. Lee is Assistant Professor of Medicine, Endocrinology, at the Yale School of Medicine in New Haven, CT, United States. Dr. Lee received her undergraduate B.S. degree from UCLA in Los Angeles, CA and her M.D. degree from New York University School of Medicine in New York, NY. She completed her internship and residency in Internal Medicine as well as her fellowship in Endocrinology and Metabolism at Yale-New Haven Hospital in New Haven, CT. Dr. Lee has a clinical practice that treats patients with metabolic bone disease, thyroid nodules, thyroid cancer, adrenal disease, pituitary disease, and diabetes mellitus.

Affiliations and Expertise

Assistant Professor of Medicine, Endocrinology, Yale School of Medicine, New Haven, CT, United States; Endocrinologist, VA CT Healthcare System, West Haven, CT, United States

Hanan Bassyouni

Dr. Bassyouni is heavily involved in the education of trainees at different levels of UME and PGME at the Cumming School of Medicine, the University of Calgary. She is a member of the endocrinology division which spans six medical sites across Calgary with a team of 25 members who provide their expert service in the Diabetes Center, the David Hanley Osteoporosis center, the multidisciplinary thyroid cancer and thyroid nodule clinic, the endocrine hypertension clinic, the Diabetes in Pregnancy program, the Neuroendocrine clinic and in general Endocrinology clinics. Dr. Bassyouni provides out reach endocrinology consultant service to several clinics serving underprivileged and marginalized populations.

Affiliations and Expertise

Clinical Associate Professor, Cumming School of Medicine, Faculty of Medicine, Department of Medicine, Section of Endocrinology and Metabolism, University of Calgary, Calgary, AB, Canada

Harry Peery

Dr. Peery is a professor who has taught medical and graduate students at the Cumming School of Medicine at the University of Calgary as well as at professional schools in other universities in the United States and Canada. In addition, he is an Affiliate Assistant Professor in the Department of Bioengineering at the School of Medicine at the University of Washington, Seattle. He received his Bachelor of Science degree from Syracuse University, his MSc from Ohio State University, and his PhD from the University of Saskatchewan. At the University of Calgary, he is a member of the Department of Biochemistry and Molecular Biology and is an Associate Member of the Arnie Charbonneau Cancer Research Institute. He currently works in the lab of Dr. Karl Riabowol in the Cumming School of Medicine where he focuses his research on the pathogenesis of anti-NMDA receptor encephalitis, cancer biomarkers, and glioblastoma. He is one of the founding directors of The Anti-NMDA Receptor Encephalitis Foundation, Inc., headquartered in Ottawa, Ontario, Canada.

Affiliations and Expertise

Professor, Department of Cell Biology and Anatomy, and Arnie Charbonneau Cancer Research Institute, Laboratory of Dr. Karl Riabowol, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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