Gold Nanoparticles in Analytical Chemistry - 1st Edition - ISBN: 9780444632852, 9780444632869

Gold Nanoparticles in Analytical Chemistry, Volume 66

1st Edition

Series Volume Editors: Miguel Valcárcel Ángela López-Lorente
eBook ISBN: 9780444632869
Hardcover ISBN: 9780444632852
Imprint: Elsevier
Published Date: 21st October 2014
Page Count: 642
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Table of Contents

  • Advisory Board
  • Contributors to Volume 66
  • Series Editor's Preface
  • Volume Editor's Preface
  • Part I Generalities
    • Chapter 1. Analytical Nanoscience and Nanotechnology
      • 1. Contextualization
      • 2. Introduction to Analytical Nanoscience and Nanotechnology
      • 3. Use of Nanoparticles as Tools in Analytical Processes
      • 4. Analysis of Nanoparticles and Nanostructured Material
      • 5. Final Remarks
    • Chapter 2. Synthesis of Gold Nanoparticles
      • 1. Introduction
      • 2. Synthesis of Gold Nanoparticles in Aqueous Phase
      • 3. Synthesis of Gold Nanoparticles in Organic Phase
      • 4. Applications of Gold Nanoparticles in Analytical Chemistry
      • 5. Summary
    • Chapter 3. Physico-Chemical Characteristics of Gold Nanoparticles
      • 1. Introduction
      • 2. Optical Properties
      • 3. Quantum Chemistry of Electronic and Optical Properties
      • 4. Quantized Charge Transfer of Nanoparticle Molecules and Ensembles
      • 5. Magnetism in Gold Nanoparticles
      • 6. Chemical Properties
      • 7. Concluding Remarks
    • Chapter 4. Derivatization of Colloidal Gold Nanoparticles Toward Their Application in Life Sciences
      • 1. Introduction
      • 2. Synthesis and Characterization of Functional Nanoparticles Toward Biological Applications
      • 3. Conclusions and Outlook
      • Abbreviations
    • Chapter 5. Toxicity of Gold Nanoparticles
      • 1. Introduction
      • 2. Gold Nanoparticles in the Biological Field
      • 3. Toxicity of Gold Nanoparticles
      • 4. Methods for Toxicity Assessment
      • 5. Limitations in Toxicity Studies
  • Part II Gold Nanoparticles as Target Analytes: Characterization and Determination of Gold Nanoparticles
    • Chapter 6. Microscopic Techniques for the Characterization of Gold Nanoparticles
      • 1. Introduction
      • 2. Optical Microscopy
      • 3. Electron Microscopy
      • 4. Scanning Probe Microscopy
      • 5. Conclusions
      • List of Abbreviations
    • Chapter 7. Spectroscopic Techniques for Characterization of Gold Nanoparticles
      • 1. Electromagnetic Modes of Gold Nanoparticles
      • 2. Photon-Based Techniques
      • 3. Electron-Based Techniques
      • 4. Summary
    • Chapter 8. Mass Spectrometry for the Characterization of Gold Nanoparticles
      • 1. Mass Spectrometry in Nanotechnology
      • 2. Elemental Mass Spectrometry
      • 3. Hyphenated Techniques with Elemental Mass Spectrometry
      • 4. Molecular Mass Spectrometry
      • 5. A Forward Look into the Future of Mass Spectrometry in the Nanoworld
    • Chapter 9. Separation Techniques of Gold Nanoparticles
      • 1. Introduction
      • 2. Electrophoresis
      • 3. Field-Flow Fractionation
      • 4. Chromatographic Techniques
      • 5. Other Separation Techniques
    • Chapter 10. Determination of Gold Nanoparticles in Biological, Environmental, and Agrifood Samples
      • 1. Introduction
      • 2. Analytical Requirements
      • 3. Analytical Tools and Procedures for the Analysis of AuNPs
      • 4. Determination of AuNPs in Environmental Samples
      • 5. Determination of AuNPs in Biological Matrices
      • 6. Determination of AuNPs in Agrifood Samples
      • 7. Trends
  • Part III Gold Nanoparticles as Analytical Tools
    • Chapter 11. Applications of Gold Nanoparticles in Electroanalysis
      • 1. Introduction
      • 2. Gold Nanoparticles in Electrochemistry: Beginnings
      • 3. Kinds of Gold Nanostructures Employed in Electrochemical Sensors
      • 4. Deposition of AuNPs on the Surface and in the Bulk Material of Electrodes
      • 5. Electrodeposition of AuNPs for Electrochemical Applications
      • 6. Gold Nanoparticles as Probes in Electrochemical Biosensing
      • 7. Electrochemical Sensing Employing AuNPs with Different Detection Methods
      • 8. Conclusions
      • List of Abbreviations
    • Chapter 12. Spectroscopic Techniques Based on the Use of Gold Nanoparticles
      • 1. Introduction: Optical Properties of Gold Nanoparticles as a Starting Point for Use in Spectroscopic Techniques
      • 2. Gold Nanoparticles as the Basis of Spectrophotometric Methods of Determination
      • 3. Application of Gold Nanoparticles in the Development of Fluorescence-Based Methodologies
      • 4. Gold Nanoparticles in Phosphorescence Processes
      • 5. Applications of Gold Nanoparticles in Chemiluminescence Reactions
      • 6. General Conclusions to This Chapter
    • Chapter 13. Gold Nanoparticles as (Bio)Chemical Sensors
      • 1. Introduction
      • 2. Sensors Based on Colorimetric Sensing
      • 3. Gold Nanoparticle-Based Biobarcode Assay
      • 4. Sensors Based on Fluorescence-Related Phenomena
      • 5. Electrical and Electrochemical Sensing
      • 6. AuNP-Based Surface Plasmon Resonance Sensors
      • 7. Surface-Enhanced Raman Scattering-Based Sensing
      • 8. Conclusions and Future Perspectives
      • List of Abbreviations
    • Chapter 14. Lateral Flow Biosensors Based on Gold Nanoparticles
      • 1. General Introduction: Historical Perspective
      • 2. LF Technology and Its Format Assays
      • 3. Gold Nanoparticle-Based LF Biosensors
      • 4. New Trends in LF Technology
      • 5. Conclusions and Future Perspectives
  • Index


Analytical nanoscience and nanotechnology is a growing topic that is expected to have a great impact in the field of analytical chemistry. Many of the exceptional properties of gold nanoparticles make them suitable for different analytical applications and these applications allow extrapolations for their use in other fields as well. In analytical chemistry gold nanoparticles play two main roles, namely: i) As target analytes in the realm of the analysis of the nanoworld; and ii) As tools to improve analytical processes, such as the use of gold nanoparticles as components of electrodes, in spectroscopic techniques and (bio)chemical sensors and lateral flow sensors.

This book is a comprehensive review of the role of gold nanoparticles in analytical nanoscience and nanotechnology, with chapters devoted to their synthesis, physico-chemical characteristics, derivatization and potential toxicity. The main microscopic, spectroscopic and separation techniques for the characterization are reviewed as well as the developments for their determination in environmental, biological and agrifood samples.

Key Features

  • Provides an integral approach devoted to a specific nanoparticle
  • Considers gold nanoparticles as target analytes, as analytical tools and their relationships
  • Organizes the material in a novel way


Analytical chemists, engineers, biologists, and physicists working on analytical nanoscience and nanotechnology, or in fields involving gold nanoparticles such as catalysis, biological and medical applications


No. of pages:
© Elsevier 2014
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Series Volume Editors

Miguel Valcárcel Series Volume Editor

Dr. M. Valcárcel is full professor of analytical chemistry at the University of Córdoba since 1976. He is the author and co-author of 850 scientific articles (with a Hirsh factor of 49), 7 monographs, 8 textbooks and 16 chapters of books. He was the coordinator of 25 Spanish scientific research projects and 14 of international nature, as well as 12 contracts with private firms and promoter of a spin-off devoted to nanotechnology. Prof. Valcárcel has been the co-supervisor of 70 doctoral thesis and an invited lecturer in 70 international meetings. He is the recipient of relevant scientific national (e.g. Award in Chemistry in Spain, 2006) and international (e.g. Robert Boyle Medal of RSC, 2004) prizes as well as Doctor Honoris Causa from the University of Valencia (Spain, 2010).

Affiliations and Expertise

Department of Analytical Chemistry, University of Córdoba, Spain

Ángela López-Lorente Series Volume Editor

Dra. Ángela I. López-Lorente received her Ph.D. in Chemistry from the University of Córdoba (Spain) in 2013 and holds an Advanced Fine Chemistry Master and Chemistry degree from the same institution. During her Bachelor of Chemistry studies she obtained a special scientific recognition from the Spanish Ministry (Arquimedes’ Contest) for her work on membranes based on carbon nanotubes. In 2010, she received the Spanish National Award for Graduate Studies in Chemistry. Her research has concentrated on the development of analytical methodologies for both the characterization and determination of nanoparticles such as metallic nanoparticles or carbon nanotubes in environmental and biological matrices. During her doctoral studies she performed a research stay at the group of prof. Mizaikoff in the University of Ulm (Germany). Her doctoral thesis has been the recipient of the Lilly Research Award for PhD Students 2013 and the prize of the Andalusian Group of the Spanish Analytical Chemistry Society.

Affiliations and Expertise

Department of Analytical Chemistry, University of Córdoba, Spain