Glycosaminoglycans in Development, Health and Disease
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Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease.
Key Features
- This series provides a forum for discussion of new discoveries, approaches, and ideas
- Contributions from leading scholars and industry experts
- Reference guide for researchers involved in molecular biology and related fields
Readership
Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.
Table of Contents
- Mice deficient in heparan sulfate N-sulphotransferase-1
- Mice deficient in heparan sulfate epimerase
- Mice deficient in heparan sulfate 3-O-sulfotransferase-1
Nicholas W. Shworak - Mice deficient in heparan sulfate 6-O-sulfotransferase-1
- Mice deficient in dermatan sulfate Epimerase
- The roles of chondroitin-4-sulfotransferase-1 in development and disease
- Conditionally disrupted EXT1 in the embryonic mouse brain.
- Endothelial heparan sulfate in inflammation
- Endothelial heparan sulfate in angiogenesis
- Hepatocyte heparan sulfate and lipoprotein metabolism
- Serglycin proteoglycan deletion in mouse platelet
- GAGs in Amyloidosis
- Selectins, Heparins and Tumor Metastasis
- Chondroitin sulfate and Rheumatoid arthritis
- Adducted thumb-clubfoot syndrome (ACTS) and Loss of dermatan-4-sulfotransferase 1 function
- Vascular dermatan sulfate and heparin cofactor II
- Diverse Functions of Glycosaminoglycans in Infectious Diseases
- Lessons learned from contaminated heparin. 1: Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis.
- Lessons learne from contaminated heparin. 2: Contact System Activation-induced Thrombin in Unrelated Human Thromboembolic Diseases
Lena Kjellén and Maria Ringvall
Jin ping Li
Koji Kimata and Hiroko Habuchi
Marco Maccarana and Anders Malmström
Michael Klüppel
Yu Yamaguchi
Jeffrey D. Esko and Ding Xu
Jeffrey D. Esko, Mark M. Fuster and Lianchun Wang
Jeffrey D. Esko and Erin Foley
Barbara P. Schick
Jin ping Li and Xiao Zhang
Lubor Borsig
Lijuan Zhang
Jacques U Baenziger,Thomas Müller, Andreas Janecke and Lijuan Zhang
Douglas M. Tollefsen
Pyong Woo Park, Rafael Aquino, and Eui Seung Lee
Lijuan Zhang
Lijuan Zhang, Peter Weiser, Yi Qian and Jing Pan
Product details
- No. of pages: 408
- Language: English
- Copyright: © Academic Press 2010
- Published: September 15, 2010
- Imprint: Academic Press
- Hardcover ISBN: 9780123812827
- eBook ISBN: 9780123812834
About the Serial Volume Editor
Lijuan Zhang
Lijuan Zhang is a Professor of Translational Medicine at Ocean University of China. She completed her doctorates of biochemistry and molecular genetics at University of Alabama at Birmingham in 1995. Before then, she was a Fogarty International Fellow at NIH for three years studying glycan-based cancer biomarkers. She worked as post-doctorate fellow and research associate at both MIT and Harvard Medical School from 1995-2002. She joined the faculty of the Department of Pathology & Immunology at Washington University in St. Louis in 2002 as a tenure-tracked Assistant Professor. Her research had been focused on the biosynthesis, structures, and biological functions of glycans since 1985. Now her work is on translational aspects of glycans as biomarkers and therapeutics. She has over 60 peer reviewed publications. She edited and published a book entitled “Glycosaminoglycans in Development, Health, and Diseases” with the contributions of top scientists worldwide in 2010 by Elsevier.
Affiliations and Expertise
Ocean University of China, Qingdao, China