Glycosaminoglycans in Development, Health and Disease

Glycosaminoglycans in Development, Health and Disease

1st Edition - September 15, 2010

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  • Editor: Lijuan Zhang
  • Hardcover ISBN: 9780123812827
  • eBook ISBN: 9780123812834

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Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease.

Key Features

  • This series provides a forum for discussion of new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

    1. Mice deficient in heparan sulfate N-sulphotransferase-1
    2. Lena Kjellén and Maria Ringvall

    3. Mice deficient in heparan sulfate epimerase
    4. Jin ping Li

    5. Mice deficient in heparan sulfate 3-O-sulfotransferase-1
      Nicholas W. Shworak
    6. Mice deficient in heparan sulfate 6-O-sulfotransferase-1
    7. Koji Kimata and Hiroko Habuchi

    8. Mice deficient in dermatan sulfate Epimerase
    9. Marco Maccarana and Anders Malmström

    10. The roles of chondroitin-4-sulfotransferase-1 in development and disease
    11. Michael Klüppel

    12. Conditionally disrupted EXT1 in the embryonic mouse brain.
    13. Yu Yamaguchi

    14. Endothelial heparan sulfate in inflammation
    15. Jeffrey D. Esko and Ding Xu

    16. Endothelial heparan sulfate in angiogenesis
    17. Jeffrey D. Esko, Mark M. Fuster and Lianchun Wang

    18. Hepatocyte heparan sulfate and lipoprotein metabolism
    19. Jeffrey D. Esko and Erin Foley

    20. Serglycin proteoglycan deletion in mouse platelet
    21. Barbara P. Schick

    22. GAGs in Amyloidosis
    23. Jin ping Li and Xiao Zhang

    24. Selectins, Heparins and Tumor Metastasis
    25. Lubor Borsig

    26. Chondroitin sulfate and Rheumatoid arthritis
    27. Lijuan Zhang

    28. Adducted thumb-clubfoot syndrome (ACTS) and Loss of dermatan-4-sulfotransferase 1 function
    29. Jacques U Baenziger,Thomas Müller, Andreas Janecke and Lijuan Zhang

    30. Vascular dermatan sulfate and heparin cofactor II
    31. Douglas M. Tollefsen

    32. Diverse Functions of Glycosaminoglycans in Infectious Diseases
    33. Pyong Woo Park, Rafael Aquino, and Eui Seung Lee

    34. Lessons learned from contaminated heparin. 1: Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis.
    35. Lijuan Zhang

    36. Lessons learne from contaminated heparin. 2: Contact System Activation-induced Thrombin in Unrelated Human Thromboembolic Diseases

    Lijuan Zhang, Peter Weiser, Yi Qian and Jing Pan

Product details

  • No. of pages: 408
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: September 15, 2010
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123812827
  • eBook ISBN: 9780123812834

About the Serial Volume Editor

Lijuan Zhang

Lijuan Zhang is a Professor of Translational Medicine at Ocean University of China. She completed her doctorates of biochemistry and molecular genetics at University of Alabama at Birmingham in 1995. Before then, she was a Fogarty International Fellow at NIH for three years studying glycan-based cancer biomarkers. She worked as post-doctorate fellow and research associate at both MIT and Harvard Medical School from 1995-2002. She joined the faculty of the Department of Pathology & Immunology at Washington University in St. Louis in 2002 as a tenure-tracked Assistant Professor. Her research had been focused on the biosynthesis, structures, and biological functions of glycans since 1985. Now her work is on translational aspects of glycans as biomarkers and therapeutics. She has over 60 peer reviewed publications. She edited and published a book entitled “Glycosaminoglycans in Development, Health, and Diseases” with the contributions of top scientists worldwide in 2010 by Elsevier.

Affiliations and Expertise

Ocean University of China, Qingdao, China

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