Genetics, Neurology, Behavior, and Diet in Parkinson's Disease

Genetics, Neurology, Behavior, and Diet in Parkinson's Disease

The Neuroscience of Parkinson’s Disease, Volume 2

1st Edition - August 13, 2020

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  • Editors: Colin Martin, Victor Preedy
  • eBook ISBN: 9780128159514
  • Hardcover ISBN: 9780128159507

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Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about Parkinson’s disease


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Table of Contents

  • Part I: Genetics, molecular and cellular biology

    2. Alpha-synuclein gene and Parkinson’s disease
    Athina-Maria Simitsi, Chistos Koros and Leonidas Stefanis

    3. The DJ-1 gene and protein: links with Parkinson’s disease
    Vanessa J. Musco, Sarah J. Annesley and Paul R. Fisher

    4. Regulation of tyrosine hydroxylase: relevance to Parkinson’s disease
    Gelareh Alam and Jason R. Richardson

    5. Linking glucocerebrosidase gene (GBA) variants and Parkinson’s disease
    ctoria Berge-Seidl and Mathias Toft

    6. Astrocytes and microglia in Parkinson’s disease and animal models
    Katarzyna Kuter

    7. The role of autophagy in Parkinson’s disease etiopathogenesis
    Emanuel Candeias, Jãao Duarte Magalhães, Daniel Santos, Helena Costa, Diana F. Silva, Ana Raquel Esteves and Sandra Morais Cardoso

    8. The mitochondrial network in Parkinson’s disease
    Andreas Aufschnaiter, Verena Kohler and Sabrina Büttner

    9. Signal transduction in Parkinson’s disease: modulation of neurotransmission, symptomatology, and therapy
    Mattia Volta

    10. Oxidative stress signaling and regulated cell death in Parkinson’s disease
    Carlos Velez-Pardo and Marlene Jimenez-Del-Rio

    11. Subcellular-specific alpha-synuclein in Parkinson’s disease
    Benjamin Rosen, Ketan S. Patil, Guido W. Alves and Simon G. Møller

    12. Melanocortin 1 receptor: Parkinson’s disease, melanoma risk, and neuroprotection
    Gemma Tell-Marti, Joan Anton Puig-Butillé and Susana Puig

    13. Energy regulation and Parkinson’s disease
    Liting Hang and Kah-Leong Lim

    14. Linking rotigotine, Parkinson’s disease, and brain-derived neurotrophic factor
    Kazuhiro Sohya, Kazunori O’Hashi and Hiroshi Kunugi

    Part II: Neurology, physiology and imaging

    15. The different syndromes in Parkinson’s disease: an overview
    Nikolaos Giagkou and Maria Stamelou

    16. Neuromolecular imaging in Parkinson’s disease
    Patricia A. Broderick and Leslie Wenning

    17. Interlinking brain mapping and Parkinson’s disease: MRI analysis, nigrosome 1 and nigrosome 4
    Eung Yeop Kim, Young Hee Sung and Jongho Lee

    18. Interconnecting Parkinson’s disease: the use of computed tomography and microelectrode recording in DBS surgery
    Ryan B. Kochanski and Sepehr Sani

    19. Linking diffusion tensor imaging, microstructures and Parkinson’s disease
    Yu Zhang, Norbert Schuff, I-Wei Wu and Duygu Tosun

    20. Detecting parkinsonian degeneration in lateroventral tier of substantia nigra pars compacta with MRI
    Jason Langley, Daniel E. Huddleston and Xiaoping P. Hu

    21. Vagal motoneurons in Parkinson’s disease
    Ruth E. Musgrove, Wei-Hua Chiu and Joshua A. Goldberg

    22. Circadian clock disruption and neuroinflammation in Parkinson’s disease: a new perspective
    Elisabetta Lauretti and Domenico Praticò

    23. Motor cortex stimulation in Parkinson’s disease
    Angelo Lavano, Giusy Guzzi, Attilio Della Torre and Domenico La Torre

    24. Action programming disorders associated with Parkinson’s disease
    Kenneth M. Heilman

    25. The striatal medium spiny neurons: what they are and how they link with Parkinson’s disease
    Fu-Ming Zhou

    26. Disruptions of frontostriatal language functions in Parkinson’s disease
    Adolfo M. García, Yamile Bocanegra, Agustina Birba, Juan Rafael Orozco-Arroyave, Lucas Sedeño and Agustín Ibañez

    27. Alpha-synuclein and neuroinflammation in Parkinson’s disease
    Tatiana Varanita and Luigi Bubacco

    28. Tau and its interactions with other proteins in neurodegenerative diseases
    Katelyn H. Mroczek, Sarah J. Annesley and Paul R. Fisher

    29. Interaction between brain angiotensin and dopaminergic systems and Parkinson’s disease
    Jose Luis Labandeira-Garcia, Pablo Garrido-Gil, Maria A. Pedrosa, Carmen M. Labandeira and Ana I. Rodriguez-Perez

    30. Restoring dopamine levels in Parkinson’s disease: neuronal pathways, agonists and antiinflammatory agents
    Ágatha Oliveira-Giacomelli, C.M. Albino, Hellio Danny Nóbrega de Souza and Henning Ulrich

    Part III: Behaviour and psychopathology 

    31. Motivation and motivational aspects of Parkinson’s disease
    Abdeslam Chagraoui, Emilie Puginier and Philippe De Deurwaerdère

    32. Linking anxiety, cognitive and sensory deficits to gait and balance deficits in Parkinson’s disease
    Quincy J. Almeida

    33. Motor programs interlinking gait and bradykinesia in Parkinson’s disease
    Tateo Warabi, Kiyoharu Inoue and Nobuo Yanagisawa

    34. Olfactory disturbances in Parkinson’s disease
    Lais S. Rodrigues, Juliane Fagotti, Adriano D.S. Targa, Ana Carolina D. Noseda, Jessica L. Ilkiw, Flavia W.C. Dorieux and Marcelo M.S. Lima

    35. Interlinking dementia in Parkinson’s disease: nutritional correlates of body composition
    Arthur Oscar Schelp, Jéssica Emy Komuro, José Eduardo Corrente and Silvia Justina Papini

    36. The role of the gastrointestinal system and gut microbiota in Parkinson’s disease
    Jade Kenna and Ryan S. Anderton

    37. Swallowing impairment in Parkinson’s disease
    Maira Rozenfeld Olchik, Marina Padovani and Annelise Ayres

    38. The Mini Nutritional Assessment (MNA) and applications to Parkinson’s disease
    Svetlana Tomic

    39. The efficacy of Bacopa monnieri extract in modulating Parkinson’s disease
    Dr. Ravikumar Hosamani

    Part V: Models, modelling and resources

    40. 6-hydroxydopamine-induced model of Parkinson’s disease
    Katarzyna Kaczyńska and Kryspin Andrzejewski

    41. Knockdown transgenic Drosophila and Parkinson’s disease
    Marlene Jimenez-Del-Rio and Carlos Velez-Pardo

    42. Neuroprotection in animal models of Parkinson’s disease: exploring exercise, sound, and light
    John Mitrofanis

    43. Modeling with the A53T α-synuclein model of Parkinson’s disease
    Thomas Musacchio, James B. Koprich and Chi Wang Ip

    44. Linking the leucine-rich repeat kinase 2 gene, animal models, and Parkinson’s disease
    Yulan Xiong and Jianzhong Yu

    45. Neuroscience of Parkinson’s disease: recommended reading and resources
    Rajkumar Rajendram, Vinood B. Patel and Victor R. Preedy

Product details

  • No. of pages: 762
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: August 13, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128159514
  • Hardcover ISBN: 9780128159507

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King’s College London and Professor of Clinical Biochemistry (Hon) at King’s College Hospital. He was the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Emeritus Professor, King’s College London; Professor, King’s College Hospital, London, UK

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