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Genetics, Neurology, Behavior, and Diet in Parkinson's Disease - 1st Edition - ISBN: 9780128159507

Genetics, Neurology, Behavior, and Diet in Parkinson's Disease

1st Edition

The Neuroscience of Parkinson’s Disease, Volume 2

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Editors: Colin R. Martin Victor Preedy
Hardcover ISBN: 9780128159507
Imprint: Academic Press
Published Date: 7th September 2020
Page Count: 762
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Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about Parkinson’s disease


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Table of Contents

Virginia Bottomley


I. Genetics, Molecular and Cellular Biology
1. LRRK2 genes in Parkinson’s disease: from genetics to pathobiology
Elisa Greggio and Susanna Cogo
2. Alpha-synuclein gene and Parkinson’s disease
Leonidas Stefanis
3. The DJ-1 gene and protein: links with Parkinson's Disease
Paul R. Fisher
4. Gene expression in the connection between 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and tyrosine hydroxylase
Gelareh Alam and Jason Richardson
5. Linking GBA variants and Parkinson's disease
Mathias Toft
6. Astrocytes and microglia in Parkinson’s disease and its animal models
Katarzyna Z. Kuter
7. Autophagy in Parkinson’s disease
Sandra Morais Cardoso and Nilza Manadas
8. Mitochondria in Parkinson’s disease
Sabrina Buettner
9. Signal transduction in Parkinson's disease
Mattia Volta
10. Oxidative stress signaling and regulated cell death in Parkinson’s disease
Marlene Jimenez-Del-Rio and Carlos Velez-Pardo
11. Subcellular-specific alpha-synuclein in Parkinson's Disease
Simon Geir Moller and Benjamin Rosen
12. MC1R in Parkinson's disease and association with melanoma risk
Susana Puig and Gemma Tell-Marti
13. Energy regulation and Parkison's disease
Kah-Leong Lim
14. Linking rotigotine, Parkinsons disease and brain BDNF
H. Kunugi

II. Neurology, Physiology and Imaging
15. The different syndromes in Parkinson’s disease: an overview
Maria Stamelou and Nikolaos Giagkou
16. Neuromolecular imaging in Parkinson’s disease
P. Broderick
17. Interlinking brain mapping and Parkinson's disease: MRI analysis, nigrosome 1 and nigrosome 4
Eung Yeop Kim
18. Interconnecting Parkinson’s disease, computed tomography (CT) and microelectrode recording in deep brain stimulation
Sepehr Sani and Ryan B. Kochanski
19. Linking diffusion tensor imaging (DTI), microstructures and Parkinson’s disease
Yu Zhang
20. Hypointensity in the substantia nigra pars compacta in Parkinson’s disease
Xiaoping Hu and Jason Langley
21. Vagal motoneurons in Parkinson’s disease
Joshua A. Goldberg and Ruth Musgrove
22. Circadian clock disruption and neuroinflammation in Parkinson’s disease: a new perspective
Elisabetta Lauretti and Domenico Pratico
23. Motor cortex stimulation in Parkinson’s disease
A. Lavano
24. Action programming disorders associated with Parkinson's Disease
Kenneth M. Heilman
25. The striatal medium spiny neurons (MSNs): what they are and how they link with Parkinson's disease
Fu-Ming Zhou
26. Disruptions of frontostriatal language functions in Parkinson's Disease
Adolfo M. Garcia
27. Synuclein and neuroinflammation in Parkinson's disease
Luigi Bubacco
28. Tau and its interactions with other proteins in neurodegenerative disease
Paul R. Fisher
29. Dopamine and the renin-angiotensin system in neuronal tissues Parkinson's Disease
Jose Luis Labandeira Garcia
30. Restoring dopamine levels in Parkinson’s disease
Henning Ulrich and Ágatha Oliveira-Giacomelli

III. Behaviour and Psychopathology
31. Motivation and motivational aspects of Parkinson's disease
Abdeslam Chagraoui
32. Linking anxiety, cognitive and sensory deficits to gait and balance in Parkinson’s disease
Quincy J. Almeida
33. Interlinking motor program of gait and bradykinesia in Parkinson's disease
Tateo Warabi
34. Olfactory features in Parkinson's disease
Marcelo M. S. Lima

IV. Diet And Nutrition
35. Interlinking dementia in Parkinson's disease: and nutritional correlates of body composition
Arthur Oscar Schelp
36. The role of the gut microbiota in Parkinson's disease
Ryan Anderton and Jade Kenna
37. Swallowing defects in Parkinson’s disease
Maira Rozenfeld Olchik
38. The Mini Nutritional Assessment (MNA ) and applications to Parkinson’s disease
Svetlana Tomic
39. Bacopa monnieri extract and Parkinson’s disease
Ravikumar Hosamani

V. Models, Modelling and Resources
40. 6-hydroxydopamine-induced model of Parkinson’s disease
Katarzyna Kaczynska
41. Knockdown transgenic Drosophila and Parkinson’s disease
Carlos Velez-Pardo and Marlene Jimenez-Del-Rio
42. Evidence for neuroprotection in animal models of Parkinson’s disease
John Mitrofanis
43. Modelling with the A53T alpha-synuclein model of Parkinson’s disease
44. Linking the leucine-rich repeat kinase 2 (LRRK2) gene, animals models and Parkinson’s disease
Yulan Xiong

Rajkumar Rajendram


No. of pages:
© Academic Press 2020
7th September 2020
Academic Press
Hardcover ISBN:

About the Editors

Colin R. Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Perinatal Mental Health, Institute of Clinical and Applied Health Research (ICAHR), University of Hull, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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