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Genetic Mechanisms of Development - 1st Edition - ISBN: 9780126129755, 9781483261997

Genetic Mechanisms of Development

1st Edition

Editor: Frank H. Ruddle
eBook ISBN: 9781483261997
Imprint: Academic Press
Published Date: 1st January 1973
Page Count: 396
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Genetic Mechanisms of Development is a compilation of articles that surveys the application of genetic systems of analysis to the resolution of fundamental problems in developmental biology. The book is composed of sections that deal with various aspects of genetic mechanisms. The first section tackles the genetic analysis of gene regulation in microorganisms. The second section discusses the application of Mendelian genetics to the study of the development of Drosophila, amphibians, and the laboratory mouse. The last section introduces somatic cell genetics, a tool for developmental biologists. Biologists, geneticists, zoologists, and researchers will find the book a good source of information.

Table of Contents


Contributors and Presiding Chairmen

I. Prokaryotic Systems of Analysis

Regulation of Bacteriophage λ Development

I. Introductory Comments

II. Stages of Phage λ Development

III. The Lytic Pathway

IV. The Lysogenic Pathway

V. Summary of Phage λ Development


The Question of Gene Regulation in Sporulating Bacteria

I. Introduction

II. RNA Polymerase Loses Vegetative Template Specificity during Sporulation

III. Genetic Evidence that the Loss of Vegetative Specificity is Critical for Sporulation

IV. In Vitro Transcription of Phage Φe DNA Requires a Sigma Factor

V. Loss of Sigma Activity during Sporulation

VI. In Vitro Transcription of the B. subtilis Ribosomal RNA Genes

VII. The Switch From Vegetative to Sporulation Transcription

VIII. Isolation of a New RNA Polymerase Subunit during Sporulation

IX. RNA Polymerase and Differentiation


Genetic Control of Bacteriophage T4 Morphogenesis

I. T4 as a Model System

II. Outlining the Process of T4 Morphogenesis

III. Self-Assembly and Non-Self-Assembly in the Morphogenetic


IV. Conclusion


II. Eukaryotic Systems of Analysis

Genetics of Sperm Development in Drosophila

I. Introduction

II. The Sequential Events of Spermiogenesis

III. Y-Chromosome Function in Spermiogenesis

IV. Autosomal and X-Linked Gene Function in Spermiogenesis

V. Cellular Specificity of Gene Activity in Spermiogenesis

VI. Concluding Remarks


Genetic Control of Determination in the Drosophila Embryo

I. Introduction

II. Early Embryogenesis of Drosophila

III. Developmental Potential of Cleavage Nuclei

IV. Determination of Blastoderm Cells

V. Genetic Control of Determination

VI. Conclusion


Mapping of Behavior in Drosophila Mosaics

I. Introduction

II. Mutants with Simple Foci

III. Complex Foci

IV. Discussion

V. Conclusion


Developmental Genetics of the Axolotl

I. Introduction

II. Genes Affecting the Oocyte Cytoplasm

III. Genes Affecting the Induction of the Heart and the Eye

IV. Comments on Other Genes in the Axolotl

V. Amphibians Other than the Axolotl

VI. Summary


Necessary Conditions for Gene Expression during Early Mammalian Development

I. Introduction

II. Biochemical Changes during Early Mammalian Development

III. Is New Genetic Information Required for Development?

IV. Dependence of Differentiation and Development on Cell Interactions within the Embryo

V. Dependence of Development on the Maternal Environment—Preimplantation

VI. Dependence of Development on the. Maternal Environment—Postimplantation

VII. Conclusions


Estrogen Regulation of Ovalbumin mRNA Content and Utilization

I. Hormonal Regulation of Ovalbumin Synthesis

II. Assay and Isolation of Ovalbumin mRNA

III. The Mechanism of "Superinduction" of Ovalbumin by Actinomycin D

IV. Discussion


Sequence Organization in the Genome of Xenopus laevis

I. Introduction

II. The Repetitive DNA of the Xenopus Genome

III. Binding to Hydroxyapatite of DNA of Various Fragment Lengths

IV. Evidence for Sequence Interspersion from Melting Experiments

V. The Length of Repetitive and Nonrepetitive Sequence Elements

VI. Discussion


III. Somatic Cell Genetics Systems of Analysis

Regulation of Differentiated Phenotype in Heterokaryons

I. Introduction

II. Reactivation of the Chick Erythocyte Nucleus

III. Dedifferentiation of the Mouse Macrophage

IV. Evidence for Negative Control in Rat Liver Heterokaryons

V. General Discussion


Control of the Differentiated State in Somatic Cell Hybrids

I. Introduction

II. The Approach

III. Suppression of Differentiated Functions in Hybrid Cells

IV. Reappearance of a Differentiated Function in Hybrids following Chromosome Segregation

V. Independent Control of Multiple Differentiated Functions in Hybrid Cells

VI. Effect of Gene Dosage on the Expression of Differentiated Functions in Hybrids

VII. Discussion


Somatic Cell Genetics of Higher Plants

I. Introduction

II. Mutant Selection

III. Toward a Parasexual Cycle

IV. Parasexual Organelle Genetics

V. Existing Genetic Variation

VI. Conclusions


Social Implications of Genetic Engineering

Statement by Frank H. Ruddle

Statement by Elof A. Carlson

Statement by Margery W. Shaw

Statement by Max Tishler

Appendix Statement by James M. Gustafson

Author Index

Subject Index


No. of pages:
© Academic Press 1973
1st January 1973
Academic Press
eBook ISBN:

About the Editor

Frank H. Ruddle

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