Genetic Mechanisms of Development

Genetic Mechanisms of Development

1st Edition - January 1, 1973

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  • Editor: Frank H. Ruddle
  • eBook ISBN: 9781483261997

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Genetic Mechanisms of Development is a compilation of articles that surveys the application of genetic systems of analysis to the resolution of fundamental problems in developmental biology. The book is composed of sections that deal with various aspects of genetic mechanisms. The first section tackles the genetic analysis of gene regulation in microorganisms. The second section discusses the application of Mendelian genetics to the study of the development of Drosophila, amphibians, and the laboratory mouse. The last section introduces somatic cell genetics, a tool for developmental biologists. Biologists, geneticists, zoologists, and researchers will find the book a good source of information.

Table of Contents

  • Contents

    Contributors and Presiding Chairmen

    I. Prokaryotic Systems of Analysis

    Regulation of Bacteriophage λ Development

    I. Introductory Comments

    II. Stages of Phage λ Development

    III. The Lytic Pathway

    IV. The Lysogenic Pathway

    V. Summary of Phage λ Development


    The Question of Gene Regulation in Sporulating Bacteria

    I. Introduction

    II. RNA Polymerase Loses Vegetative Template Specificity during Sporulation

    III. Genetic Evidence that the Loss of Vegetative Specificity is Critical for Sporulation

    IV. In Vitro Transcription of Phage Φe DNA Requires a Sigma Factor

    V. Loss of Sigma Activity during Sporulation

    VI. In Vitro Transcription of the B. subtilis Ribosomal RNA Genes

    VII. The Switch From Vegetative to Sporulation Transcription

    VIII. Isolation of a New RNA Polymerase Subunit during Sporulation

    IX. RNA Polymerase and Differentiation


    Genetic Control of Bacteriophage T4 Morphogenesis

    I. T4 as a Model System

    II. Outlining the Process of T4 Morphogenesis

    III. Self-Assembly and Non-Self-Assembly in the Morphogenetic


    IV. Conclusion


    II. Eukaryotic Systems of Analysis

    Genetics of Sperm Development in Drosophila

    I. Introduction

    II. The Sequential Events of Spermiogenesis

    III. Y-Chromosome Function in Spermiogenesis

    IV. Autosomal and X-Linked Gene Function in Spermiogenesis

    V. Cellular Specificity of Gene Activity in Spermiogenesis

    VI. Concluding Remarks


    Genetic Control of Determination in the Drosophila Embryo

    I. Introduction

    II. Early Embryogenesis of Drosophila

    III. Developmental Potential of Cleavage Nuclei

    IV. Determination of Blastoderm Cells

    V. Genetic Control of Determination

    VI. Conclusion


    Mapping of Behavior in Drosophila Mosaics

    I. Introduction

    II. Mutants with Simple Foci

    III. Complex Foci

    IV. Discussion

    V. Conclusion


    Developmental Genetics of the Axolotl

    I. Introduction

    II. Genes Affecting the Oocyte Cytoplasm

    III. Genes Affecting the Induction of the Heart and the Eye

    IV. Comments on Other Genes in the Axolotl

    V. Amphibians Other than the Axolotl

    VI. Summary


    Necessary Conditions for Gene Expression during Early Mammalian Development

    I. Introduction

    II. Biochemical Changes during Early Mammalian Development

    III. Is New Genetic Information Required for Development?

    IV. Dependence of Differentiation and Development on Cell Interactions within the Embryo

    V. Dependence of Development on the Maternal Environment—Preimplantation

    VI. Dependence of Development on the. Maternal Environment—Postimplantation

    VII. Conclusions


    Estrogen Regulation of Ovalbumin mRNA Content and Utilization

    I. Hormonal Regulation of Ovalbumin Synthesis

    II. Assay and Isolation of Ovalbumin mRNA

    III. The Mechanism of "Superinduction" of Ovalbumin by Actinomycin D

    IV. Discussion


    Sequence Organization in the Genome of Xenopus laevis

    I. Introduction

    II. The Repetitive DNA of the Xenopus Genome

    III. Binding to Hydroxyapatite of DNA of Various Fragment Lengths

    IV. Evidence for Sequence Interspersion from Melting Experiments

    V. The Length of Repetitive and Nonrepetitive Sequence Elements

    VI. Discussion


    III. Somatic Cell Genetics Systems of Analysis

    Regulation of Differentiated Phenotype in Heterokaryons

    I. Introduction

    II. Reactivation of the Chick Erythocyte Nucleus

    III. Dedifferentiation of the Mouse Macrophage

    IV. Evidence for Negative Control in Rat Liver Heterokaryons

    V. General Discussion


    Control of the Differentiated State in Somatic Cell Hybrids

    I. Introduction

    II. The Approach

    III. Suppression of Differentiated Functions in Hybrid Cells

    IV. Reappearance of a Differentiated Function in Hybrids following Chromosome Segregation

    V. Independent Control of Multiple Differentiated Functions in Hybrid Cells

    VI. Effect of Gene Dosage on the Expression of Differentiated Functions in Hybrids

    VII. Discussion


    Somatic Cell Genetics of Higher Plants

    I. Introduction

    II. Mutant Selection

    III. Toward a Parasexual Cycle

    IV. Parasexual Organelle Genetics

    V. Existing Genetic Variation

    VI. Conclusions


    Social Implications of Genetic Engineering

    Statement by Frank H. Ruddle

    Statement by Elof A. Carlson

    Statement by Margery W. Shaw

    Statement by Max Tishler

    Appendix Statement by James M. Gustafson

    Author Index

    Subject Index

Product details

  • No. of pages: 396
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9781483261997

About the Editor

Frank H. Ruddle

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