Volume 42. Genetic Dissection of Complex Traits

Contributors. Preface. Acknowledgments. NEWTON MORTON'S CONTRIBUTIONS Newton Morton: The Wisconsin Years. Newton Morton's Influence on Genetics: The Morton Number. OVERVIEW AND PRELIMINARIES Genetic Dissection of Complex Traits: An Overview. Familial Resemblance and Heritability. Linkage and Association: Basic Concepts. PHENOTYPES AND GENOTYPES Definition of the Phenotype. Genotyping for Human Whole-Genome Scans: Past, Present, and Future. MODEL-BASED METHODS FOR LINKAGE ANALYSIS The Lod Score Method. Extension of the Lod Score: The Mod Score. Major Strengths and Weaknesses of the Lod Score Method. MODEL-FREE METHODS FOR LINKAGE AND ASSOCIATION ANALYSIS Overview of Model-free Methods for Linkage Analysis. Variance Component Methods for Detecting Complex Trait Loci. Linkage and Association with Structural Relationships. The Future of Genetic Case-Control Studies. Cost of Linkage versus Association Methods. Genotype-Environment Interaction in Transmission Disequilibrium Tests. Major Strengths and Weaknesses of Model-free Methods. MORE RECENT METHODS Meta-analysis for Model-free Methods. Classification Methods for Confronting Heterogeneity. Applications of Neural Networks for Gene Finding. Genome Partitioning and Whole-Genome Analysis. Deciphering the Genetic Architecture of a Multivariate Phenotype. OPTIMUM STRATEGIES On the Resolution and Feasibility of Genome Scanning Approaches. One-Stage versus Two-Stage Strategies for Genome Scans. MULTIPLE COMPARISONS AND SIGNIFICANCE LEVELS Significance Levels in Genome Scans.