Genetic Control of Natural Resistance to Infection and Malignancy

Genetic Control of Natural Resistance to Infection and Malignancy

1st Edition - January 1, 1980

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  • Editor: Emil Skamene
  • eBook ISBN: 9780323144391

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Genetic Control of Natural Resistance to Infection and Malignancy is a collection of papers presented at the 1980 Proceedings of an International Symposium of the Canadian Society for Immunology held in Montreal, Quebec. It provides information about the different models of genetic resistance to various diseases. The book offers an overview of the genetic determination of the susceptibility or resistance to infection and malignancy. It also discusses the importance of genetic resistance not only in the first-line observation of infections and tumors, but also in chemotherapy and immunotherapy. It then explains the genetic control of resistance to parasitic, bacterial, and virus infections, as well as to tumor growth. It further discusses the genetic control of macrophage differentiation and function.

Table of Contents

  • Contributors



    Section I. Genetic Control of Resistance to Parasitic Infections

    Recombinant Inbred Strains of Mice: Use in Genetic Analysis of Disease Resistance

    Genetic Control of Resistance to Protozoal Infections

    Studies on the Genetic Control of Visceral Leishmaniasis in Balb/c Mice by L. Tropica

    Infection with Leishmania Tropica Major: Genetic Control in Inbred Mouse Strains

    The Response to Therapeutical Treatment of Resistant and Susceptible Mice Infected with Leishmania Mexicana

    Genetic Control of Immunologically Mediated Resistance to Helminthic Infections

    Variation in Anti-Trichinella Responsiveness in Inbred Mouse Strains

    MHC-Linked Genetic Control of the Immune Response to Parasites: Trichinella spiralis in the Mouse

    Immunomodulation and Altered Resistance to Infection in Different Mouse Strains Infected with Nippostrongylus brasiliensis

    Genetic Control of Natural Resistance to Trypanosoma rhodesiense in Mice

    Chairman's Summary: Genetic Control of Resistance to Parasitic Infections

    Section II. Genetic Control of Resistance to Bacterial Infections

    Differential Sensitivity of Inbred Mice to Salmonella typhimurium: A Model for Genetic Regulation of Innate Resistance to Bacterial Infection

    The C3HeB/FeJ Mouse, a Strain in the C3H Lineage which Separates Salmonella Susceptibility and Immunizability from Mitogenic Responsiveness to Lipopolysaccharide

    Natural Resistance to Mouse Typhoid: Possible Role of the Macrophage

    Control of Resistance to Salmonella typhimurium in Hybrid Generations of Inbred Mice and Biozzi Mice

    A Single Gene (Lr) Controlling Natural Resistance to Murine Listeriosis

    Cellular Mechanisms of Genetically Determined Resistance to Listeria monocytogenes

    Genetic Control of Natural Resistance to Rickettsia tsutsugamushi Infection in Mice

    Susceptibility of (CBA/N DBA/2)F1 Male Mice to Infection with Type 3 Streptococcus pneumoniae

    Genetically Controlled Natural Resistance of Mice to Plague Infection and Its Relationship to Genetically Controlled Cell-Mediated Immune Resistance

    Genetic Control of Delayed-Type Hypersensitivity to Mycobacterium bovis BCG Infection in Mice

    Genetic Control of BCG-Induced Chronic Granulomatous Inflammation and Anergy

    Murine Leprosy as a Model for the Analysis of Genetic Factors Controlling Resistance to Mycobacterial Infection

    Chairman's Summary: Genetic Control of Resistance to Bacterial Infections

    Section III. Genetic Control of Resistance to Virus Infection

    Is Genetic Resistance to Mouse Hepatitis Based on Immunological Reactions?

    Host Defense Mechanisms in Genetic Resistance to Viral Infections

    Genetic Study of MHV3 Infection in Mice: In Vitro Replication of Virus in Macrophages

    Genetic Control of Resistance to JHM, a Neurotropic Strain of Mouse Hepatitis

    Genetic Resistance to Herpesvirus Infections: Role of Natural Killer Cells

    Studies of Resistance of Mice against Herpes Simplex Virus

    Association of Host Genotype with the Augmentation of Natural Killer Cells and Resistance to Murine Cytomegalovirus

    Genetic Resistance to Murine Cytomegalovirus Infection

    Genetics of Macrophage-Controlled Natural Resistance to Hepatitis Induced by Herpes Simplex Virus Type 2 in Mice

    Genetically Controlled Resistance to Togaviruses

    Genetic Resistance to Lethal Flavivirus Infection: Detection of Interfering Virus Produced in Vivo

    The Role of H-2 in Resistance and Susceptibility to Measles Virus Infection

    Ir Gene Regulation of Sensitivity to Leukemogenesis by RadLV Variants and Its Relationship to Preleukemic Cells

    Recovery from Friend Virus Leukemia Is Determined by the H-2 Genotype of Nonleukemic Cells of the Spleen and Bone Marrow

    Use of an Infectious Center Assay to Study FV-2-Mediated Resistance of Mouse Bone Marrow Cells to Friend Spleen Focus-Forming Virus

    Genetically Acquired Resistance to Fatal Pichinde Virus Infection in the Syrian Hamster

    Subacute Sclerosing Panencephalitis in Inbred Hamsters

    Marek's Disease in Chickens: Genetic Resistance to a Viral Neoplastic Disease. A Review

    Relationship between Tumorigenicity and Immunosuppression in Resistant and Susceptible Strains of Mice Infected with Friend Leukemia Virus

    Viral Inhibition of Lymphocyte Mitogenesis: Immunological Characterization of an Inhibitory Factor Derived from Adherent Cells

    Chairman's Summary: Genetic Control of Natural Resistance to Viral Infections

    Section IV. Genetic Control of Natural Resistance to Tumor Growth

    Genetic Control of in Vitro NK Reactivity and Its Relationship to in Vivo Tumor Resistance

    Different Genes Regulate Tumor Cell Recognition and Cytolysis by NK Cells in the Mouse

    Heterogeneity of Natural Killer Cells: A Serological Study with Specific Anti-NK Alloantisera

    The Chediak-Higashi Gene in Humans Controls NK Function

    Analysis of the Genetic Control of Natural Killer Cell Activity May Require Studies of Genetics with Segregating Alleles among Littermates

    Genetic Resistance to Tumors: Roles of Marrow-Dependent and -Independent Cells

    H-2 Dependent and Independent Natural Resistance to Leukaemia Transplantation in Irradiated and Nonirradiated Mice

    Natural Surveillance of NK-Resistant Tumors. The Role of Natural Anti-Tumor Antibody (NAb) and Macrophages (mph)

    Differential Tumor Susceptibility and Immune Responsiveness in HRS/J Mice

    Hybrid Resistance to Parental Tumors: Influence of Host and Tumor Genotype and Tumor Derivation

    Preliminary Analysis of Hybrid Resistance to Histocompatible P815 Utilizing Bone Marrow and Thymus Epithelium Radiation Chimeras

    Genetic Control of Natural Resistance to Graft versus Host-Associated Suppression of T Cell-Mediated Lympholysis

    Chairman's Summary: Genetic Control of Natural Resistance to Tumor Growth

    Section V. Genetic Control of Macrophage Differentiation and Function

    The Genetic Basis of Macrophage Colony Formation

    An LPS Responsive Cell in C3H/HeJ Mice: The Peritoneal Exudate-Derived Macrophage Colony-Forming Cell (M-CFC)

    Activity of Macrophage Cell Lines in Spontaneous and LPS, Lymphokine or Antibody-Dependent Killing of Tumor Targets

    Macrophage Cell Line Mutants Deficient in Phagocytosis Have Reduced Pinocytic Activity

    Macrophage Activation for Tumor Cytotoxicity: Genetic Influences on Development of Macrophages with Nonspecific Tumoricidal Activity

    Activated Macrophages in Natural Resistance to Rickettsia akari

    Macrophage Inflammatory Responses in Listeria-Resistant and Listeria-Sensitive Mice

    The Beige (Chediak-Higashi Syndrome) Mouse as a Model for Macrophage Function Studies

    Defective Fc-Mediated Phagocytosis by LPS-Hyporesponsive (Lpsd) C3H/HeJ Macrophages: Correction by Agents that Elevate Intracellular Cyclic AMP

    Chairman's Summary: Genetic Control of Macrophage Differentiation and Function


Product details

  • No. of pages: 620
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323144391

About the Editor

Emil Skamene

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