Gene Function

Gene Function

FEBS Federation of European Biochemical Societies: 12th Meeting, Dresden, 1978

1st Edition - January 1, 1979

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  • Editors: S. Rosenthal, H. Bielka, Ch. Coutelle
  • eBook ISBN: 9781483188515

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Gene Function, contains the proceedings of the 12th Meeting of the Federation of European Biochemical Societies held in Dresden, Germany in 1978. The meeting provided a forum for discussing progress in the understanding of gene function and covered topics ranging from the functional organization of chromatin to principles of interactions and recognition models. The role of DNA sequence in the recognition of restriction endonucleases and modification enzymes is also examined, along with gene expression, RNA processing and modification, and isolation and synthesis of genes. Comprised of 49 chapters, this volume begins with an overview of what can be learned from the genetic analysis of the lac repressor, followed by a discussion on the topography of the interaction the lac repressor, RNA polymerase, and histones with DNA. The reader is then introduced to complementarity and recognition code between regulatory proteins and DNA; chromatin replication in vitro; and the cytoplasmic "petite" mutation in Saccharomyces cerevisiae. Subsequent chapters explore arc-like and helical arrangements of nucleosome cores; changes in gene expression during cellular differentiation; polyadenylation and processing of pre-messenger RNA; and the molecular biology of bacteriophages T3 and T7. This book will be of interest to geneticists, biochemists, and molecular biologists.

Table of Contents

  • Preface

    Functional Organisation of Chromatin

    What can b e Learned from t h e Genetic Analysis of LAC Repressor?

    Topography of Interaction of LAC Repressor, RNA Polymerase and Histones with DNA

    Complementarity and Recognition Code Between Regulatory Proteins and DNA

    Enzyme-DNA and Repressor-Operator Recognitions. Regulatory Elements in the Immunity Regions of Phages λ and 434

    Chromatin Replication in Vitro

    Transcription of the Globin Gene in Isolated Mouse Foetal Liver Chromatin

    Principles of Interactions and Recognition Models

    The Recognition of Nucleic Acid Structures and Base Sequences by Proteins. Role of Stacking and Hydrogen Bonding Inter-Actions

    Localized Positive Charges can Bend Double Helical Nucleic Acid

    Recognition of the DNA Double-Helix by Model Oligopeptides and Implications for Protein Interactions

    On the Interactions of Genome-Regulatory Proteins with DNA

    Nature of Protein-DNA Interactions Revealed by Model Polypeptide Complexes

    Role of DNA Sequence in the Recognition of Restriction Endonucleases and Modification Enzymes

    The Cytoplasmic "Petite" Mutation in Saccharowces Cerevisiae

    Complete Nucleotide Sequence of SV40 DNA

    Restriction Endonucleases as Tools in Physical Mapping and Restructuring of Bacterial DNA

    On the Cleavage of Virus DNA by Restriction Endonuclease Eco RI

    S-Adenosyl-L-Methionine-Dependent Deoxyribonucleases of Eukaryotic Origin

    Functional Organization of Chromatin

    The Structure of Chromatin Core Particles and the Higher Order Structure of Chromatin

    X-ray and Electron Microscope Studies on the Nucleosom Structure

    Arc-Like and Helical Arrangements o f Nucleosom Cores

    Properties of Soluble Unsheared Chromatin

    Use of Restriction Nucleases in the Analysis of Chromatin Structure

    Gene Expression

    Changes in Gene Expression During Cellular Differentiation

    The Spliced Messenger RNAs of Adenovirus-2

    Synthesis and Expression of Chironomus Thummi Balbiani Ring RNA

    Gene Expression in Lampbrush Chromosomes

    Processing and Modification of RNA

    A Novel Type of Gene Organization in Eurkaryotic Chromosomes

    Enzymes and Mechanisms in RNA Processing

    5'-Terminal Caps in Eukaryotic mRNAS

    Polyadenylation and Processing of Pre-mRNA

    Control of Ribosomal RNA Processing in Eukaryotes

    Molecular Biology of Bacteriophages T3 and T7

    T7 DNA Replication - a Brief Introduction

    Virus T7: A Probe of Cellular Control Mechanisms

    Molecular Biology of Bacteriophages T3 and T7: Role of Early Phage Genes for Virus-Host Interactions


    The Escherichia Coli Ribosome

    Principles of Structural Organization of Ribosomes

    An Allosteric Ribosome Domain

    Structural and Functional Organization of the Eukaryotic Ribosome - Studies on Proteins of Rat Liver Ribosoms

    Organization and Transcription of Genes Coding for Ribosomal Components in Eukaryotes

    Control of Protein Synthesis

    The Regulation of Protein Synthesis by Interferon

    Role of Polyadenylate Segment in Stability of Eukaryotic Messenger RNAs

    Recognition Between Codon and Anticodon. The Limits of our Knowledge

    Isolation and Synthesis of Genes

    Synthesis and Cloning of Lactos Operator DNA of E. coli

    Procedures for the Isolation and Characterization of Specific Genes from Animal Cells

    Structure of a Cloned tDNA Repeat Unit from Xenopus Laevis

    The Structure of Cloned Rabbit and Mouse β-Globin Genes

    Construction of Hybrid Vectors and Transfer of Genes

    Plasmid Vectors: General Principles of their Construction

    Mammalian Viruses as Vectors for the Introduction of Foreign Genes into Mammalian Cells

    Transfer of Genes into Plants Via the Ti-Plasmid of A. Tumefaciens

    Benefits and Potential Hazards of Genetic Engineering - Report of a Round Table Discussion

    Author Index

    Subject Index

Product details

  • No. of pages: 564
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483188515

About the Editors

S. Rosenthal

H. Bielka

Ch. Coutelle

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