COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Gene Activity in Early Development - 1st Edition - ISBN: 9781483231853, 9781483261478

Gene Activity in Early Development

1st Edition

Author: Eric H. Davidson
eBook ISBN: 9781483261478
Imprint: Academic Press
Published Date: 1st January 1968
Page Count: 388
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Gene Activity in Early Development reviews the state of knowledge regarding genomic function in the programming and operation of what Bonnet, in 1762, described as "the miracle of epigenesis." The book is divided into four sections. Section I is concerned with gene activity in early embryogenesis, with the time of onset and the nature of embryo genome control, and with recent attempts to analyze the shifting patterns of gene expression as development proceeds. Section II reviews various classic and recent studies relevant to the phenomenon of cytoplasmic localization of morphogenetic potential and discusses the significance, from a contemporary vantage point, of this often neglected area of developmental biology. Section III deals with genomic function in oogenesis, beginning with a general survey of what could be described loosely as the natural history of the oocyte nucleus, and proceeding to current attempts to understand the character and the ultimate function of the oocyte gene products. Section IV discusses various aspects of the general problem of gene regulation in animal cells.

Table of Contents


I Gene Activity in Early Embryogenesis

1. The Variable Gene Activity Theory of Cell Differentiation

2. The Onset of Genome Control in Embryogenesis

3. Early Molecular Indices of Differentiation

4. RNA Synthesis in the Early Embryo

5. The Fate and Function of Early Informational RNA

6. Maternal Template RNA


II Cytoplasmic Localization and the Onset of Differentiation

1. The Localization Phenomenon

2. Localization and Preformationism

3. Definitive Experimental Evidence for Localization

4. Regulative and Mosaic Development, and the Universality of Morphogenetic Determinants in Egg Cytoplasm

5. Demonstrations of Localization in Regulative Embryos

6. Interpretations of the Localization Phenomenon


III Gene Function in Oogenesis

1. Origin and Differentiation of the Female Germ Line

2. Clues to Oocyte Genome Function from Organisms Displaying Chromosome Elimination

3. Accessory Cell Functions in Oogenesis

4. Gene Activity in the Oocyte Nucleus: Ribosomal RNA Synthesis

5. Gene Activity in the Oocyte Nucleus: Synthesis of Informational RNA

6. DNA of the Oocyte Cytoplasm


IV Immediacy of Gene Control and Theregulation of Gene Activity

1. Very Long-Lived Gene Products

2. Moderately Long-Lived Informational RNA

3. Rapidly Decaying Template RNA

4. The Rapidity of Variations in Gene Activity in Differentiated Cells

5. Characteristics of Bacterial Repression-Derepression Systems

6. Characteristics of Gene Regulation Systems in Differentiated Cells

7. Some Hypotheses Regarding the Nature of Genomic Regulation in Differentiated Cells





No. of pages:
© Academic Press 1968
1st January 1968
Academic Press
eBook ISBN:

About the Author

Eric H. Davidson

Ratings and Reviews