Description

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.

Key Features

  • Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain
  • Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes
  • Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants

Readership

Researchers in neuroscience, neuropsychology, psychiatry and biology

Table of Contents

About the Editor

List of Contributors

PART I: The Physiology of Gap Junctions in the Brain

Chapter 1. Gap Junctions in the Brain

Introduction

Structural Aspects of Gap Junctions

Types of Gap Junction

Cellular and Brain Regional Expression Patterns of Specific Connexins

Gap Junction Pharmacology

Synchronization and Rhythmic Oscillation of Neural Activity

Gap Junction-Related Human Diseases

Conclusion

Acknowledgments

REFERENCES

Chapter 2. Physiology and Function of Glial Gap Junctions in the Hippocampus

The Connexin Gene Family

Intercellular Communication Mediated By Connexins

Hemichannel Functions of Connexins

Non-Channel Functions of Connexins

Expression Pattern of Glial Connexins in the Hippocampus: Molecular, Subcellular and Cellular Heterogeneity

Heterocellular Coupling and Panglial Coupling Compartments

Functions of Glial Gap Junctions: Controlling Neurogenesis and Neuronal Activity

Acknowledgments

REFERENCES

PART II: Gap Junctions Between Astrocytes, Neurons, and Glia–Neuron Interactions

Chapter 3. Pathophysiology of Gap Junctions in the Brain

Introduction

Gap Junctions: Nomenclature and General Properties

Gap Junction Coupling in the Brain

Cell-Specific Expression of Connexins in Brain Tissues

Modulation and Regulation of Electrical Synapses

Neurotransmitter Modulation and Connexin Phosphorylation

Gap Junction-Related Neurological Diseases

Gap Junctions and Behavior

Pharmacology of Gap Junctions

Conclusion

REFERENCES

Chapter 4. Astroglial Calcium Signaling and Calcium Waves

Introduction

Glial Calcium Excitability

Astroglia: Homeostatic Cells of the Brain

Calcium Signaling in Astrocytes

Astroglial Calcium Waves

C

Details

No. of pages:
304
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Electronic ISBN:
9780124159273
Print ISBN:
9780124159013

About the editor

Ekrem Dere

Ekrem Dere is full professor for the Pathophysiology of Cerebral Aging at the Pierre et Marie Curie University in Paris, France. His former team at the University in Düsseldorf, Germany, has provided the first behavioral evidence demonstrating that gap junctions in the brain play an important role in various behavioral processes.

Reviews

"Dere…introduces types of gap junctions, their structural aspects, expression patterns of connexins (transmembrane proteins), and gap junction- related diseases due to mutations in connexin genes. International researchers working in this emerging field discuss specific connexin genes and their mechanisms of action and function in the developing neocortx, behavior, and neurological and neuropsychiatric diseases." --Reference and Research Book News, February 2013