G Protein-Coupled Receptors in Health and Disease, Part A, Volume 88

1. Rhodopsin-Mediated Retinitis Pigmentosa

Katherine M. Malanson and Janis Lem

2. Human Diseases Associated with GPR54 Mutations

Milena Gurgel Teles, Leticia Ferreira Gontijo Silveira, Suzy Bianco and Ana Claudia Latronico

3. Diseases Associated with Growth Hormone-releasing hormone Receptor (GHRHR) Mutations

Marco Martari and Roberto Salvatori

4. The Melanocortin-1 Receptor Gene Polymorphism and Association with Human Skin Cancer

Kimberley A. Beaumont, Yan Yan Liu and Richard A. Sturm

5. The Molecular Basis of Adrenocorticotrophin Resistance Syndrome

Lucila L K Elias and Adrian J L Clark

6. Mutations in melanocortin-4 receptor and human obesity

Ya-Xiong Tao

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

* This series provides a forum for discussion of new discoveries, approaches, and ideas
* Contributions from leading scholars and industry experts
* Reference guide for researchers involved in molecular biology and related fields

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.