Fundamentals of Toxicologic Pathology

Fundamentals of Toxicologic Pathology

3rd Edition - October 24, 2017

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  • Editors: Matthew Wallig, Brad Bolon, Wanda Haschek, Colin Rousseaux
  • Hardcover ISBN: 9780128098417
  • eBook ISBN: 9780128098424

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Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.

Key Features

  • Presents revised and updated information for each chapter on systems
  • Contains expanded sections on applied toxicologic pathology
  • Includes the essential information necessary to understand toxicologic pathology in an accessible language


Toxicologists, toxicologic pathologists, medical doctors, veterinary pathologists, graduate students, and those working in regulatory affairs, pharmacology, pharmacokinetics, animal models, or clinical development

Table of Contents

  • 1. Overview of Toxicological Pathology

    Part I: Principles of Toxicologic Pathology
    2. Biochemical and Molecular Basis of Toxicity
    3. Pharmacokinetics & Toxicokinetics
    4. Principles of Pharmacodynamics & Toxicodynamics
    5. Morphologic Manifesations of  Toxic Cell Injury
    6. Carcinogenesis: Mechanisms and Manifestation
    7. Design of Studies & Risk Management in Toxicologic Pathology

    Part II: Systems Toxicologic Pathology
    8. Hepatobiliary System
    9. Cardiovascular System
    10. Muscular System
    11. Urinary System
    12. Immune System
    13. Hematopoietic System
    14. Respiratory Tract
    15. Digestive Tract
    16. Exocrine Pancreas
    17. Male Reproductive System
    18. Female Reproductive System
    19. Mammary Gland
    20. Endocrine System
    21. Nervous System
    22. Special Senses: Ocular Sytem
    22b. Special Senses: Auditory System
    23. Skeletal System (Bone & Joint)
    24. Integumentary System
    25. Embryo, Fetus & Placenta

Product details

  • No. of pages: 902
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: October 24, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128098417
  • eBook ISBN: 9780128098424

About the Editors

Matthew Wallig

Professor Wallig, DVM, PhD, DACVP is a Diplomate of the American College of Veterinary Pathologists. He is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables and soy, and the pathophysiology of pancreatic injury.

Affiliations and Expertise

Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Brad Bolon

Brad Bolon, DVM, MS, PhD, DACVP, DABT, FATS, FIATP, President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA During a 25-year career, Dr. Bolon has been employed in academia, contract research organizations, and two pharmaceutical firms before launching an experimental and toxicologic pathology practice. His main professional interests include comparative pathology of genetically engineered animals and toxicologic neuropathology. He is a past president of the Society of Toxicologic Pathology and is a recipient of the 2018 British Society of Toxicological Pathology’s Gopinath Lecture Award for excellence in toxicologic pathology.

Affiliations and Expertise

President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA

Wanda Haschek

Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011. -Diplomate of the American College of Veterinary Pathologists (ACVP) -Diplomate of the American Board of Toxicology (ABT) -Fellow of the International Academy of Toxicologic Pathologists (FIATP)

Affiliations and Expertise

University of Illinois at Urbana-Champaign

Colin Rousseaux

Professor Rousseaux, BVSc [Hons], PhD, DABT, FRCPath, FIATP, FATS is a Fellow of the Royal College of Pathology, Diplomate of the American Board of Toxicology, Fellow of the Academy of Toxicological Sciences, and Fellow of the International Academy of Toxicologic Pathology. He is Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceutical, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former president of the Society of Toxicologic Pathology.

Affiliations and Expertise

Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa, Principal, Colin Rousseaux and Associates, Canada

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