Fundamentals of Nanotoxicology

Concepts and Applications

1st Edition - April 27, 2022

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Author: P.K. Gupta
eBook ISBN: 9780323906906
Paperback ISBN: 9780323903998

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Description

Fundamentals of Nanotoxicology: Concepts and Applications provides an outline to fundamental concepts of nanotoxicology and their applications. The book opens historical oversights on nanotechnology, terminology, comparison of nanomaterial sizes, and an overview of regulations. It then goes on to cover types, classifications, sources and properties. It also delves into mechanisms of toxicity as well as health and safety assessments. Biomedical, agricultural, and food applications are explored, and ecotoxicology and the environmental impact on nanomaterials rounds out the book’s overview of this topic. This book will be a helpful resource for understanding concepts and current knowledge to academics, advanced students, and researchers interested in entering or learning more about this interdisciplinary field of study.

Key Features

Provides types, classifications, sources, properties, the application of nanomaterials, and impacts on humans and the environment
Includes risk, hazard and exposure assessments, risk characterizations and testing strategies
Discusses mechanisms of toxicity, organ and non-organ directed toxicity, and mammalian toxicology of nanomaterials

Readership

Advanced undergraduate, graduate students, PhD students, and professors in toxicology, nanotechnology, and material science. Researchers entering or learning a new or adjacent (interdisciplinary) research area in toxicology, nanotechnology, and material science

Cover image
Title page
Table of Contents
Copyright
About the author
Preface
Disclaimer
Chapter 1. Introduction, historical glimpse and regulations
Abstract
1.1 Introduction
1.2 Key points
1.3 Overview
1.4 Historical oversight
1.5 Terminology for nanomaterials
1.6 Overview of regulations
1.7 Ultrafine particles versus nanomaterials, an overview
1.8 Future of nanotoxicology
Reference
Further reading
Chapter 2. Types, classification, and applications
Abstract
2.1 Introduction
2.2 Key points
2.3 Overview
2.4 Nanomaterials and bulk materials
2.5 Behavior of nanoparticles versus larger particles
2.6 Categories of nanomaterials
2.7 Origin
2.8 Dimensionality (geometry)
2.9 Morphology
2.10 Chemical composition
2.11 Uniformity and agglomeration
2.12 Nanocomposites
2.13 Hybrid nanomaterials
2.14 Applications
2.15 Concluding remarks
References
Further reading
Chapter 3. Sources and properties
Abstract
3.1 Introduction
3.2 Key points
3.3 Overview
3.4 Properties
3.5 Sources
Further reading
Chapter 4. Synthesis, characterization and uses
Abstract
4.1 Introduction
4.2 Key points
4.3 Overview
4.4 Synthesis
4.5 Production approaches
4.6 Hybrid nanomaterials
4.7 Magnetic nanoparticles
4.8 Key Issues in the fabrication
4.9 Detection, characterization, and isolation
References
Further reading
Chapter 5. Health and safety assessment
Abstract
5.1 Introduction
5.2 Key points
5.3 Overview
5.4 Sustainable nanotechnology
5.5 Registration, evaluation, authorization, and restriction of chemicals regulation
5.6 Testing strategies
5.7 Risk assessment
5.8 Challenges
5.9 Conclusion
References
Further reading
Chapter 6. Mechanism of nanotoxicity
Abstract
6.1 Introduction
6.2 Key points
6.3 Overview
6.4 Terminology
6.5 Entry sites and uptake
6.6 Elimination of nanomaterials
6.7 Cell membrane processes
6.8 Processes of nanotoxicity
6.9 Mechanistic pathways of cellular dysfunction
6.10 Concluding remarks
References
Further reading
Chapter 7. Organ and nonorgan-directed toxicity
Abstract
7.1 Introduction
7.2 Key points
7.3 Overview
7.4 Nanoparticles versus larger particles
7.5 Factors affecting nanotoxicity
7.6 Portals of entry
7.7 Overview of behavior
7.8 Potential adverse effects of nanomaterials
7.9 Organ nanotoxicity
7.10 Nontarget-directed toxicity
7.11 Conclusion
References
Further reading
Chapter 8. Biomedical applications
Abstract
8.1 Introduction
8.2 Key points
8.3 Overview
8.4 Nanomaterials
8.5 Advantages and limitations
8.6 Applications
8.7 Drug delivery
8.8 Bioimaging
8.9 Photoablation therapy (photodynamic and photothermal therapy)
8.10 Biosensors
8.11 Tissue engineering
8.12 Diseases and disorders
8.13 Trojan horse mechanism
8.14 Interactions/biocompatibility
8.15 Toxicity and potential risks
8.16 Conclusions
References
Further reading
Chapter 9. Food and food packaging
Abstract
9.1 Introduction
9.2 Key points
9.3 Overview
9.4 Characteristics and types of nanoparticles
9.5 Food sectors
9.6 Food matrix effects
9.7 Nanotoxicology mechanisms
9.8 Potential risks and regulations
9.9 Conclusion
References
Further reading
Chapter 10. Sustainable agriculture
Abstract
10.1 Introduction
10.2 Key points
10.3 Overview
10.4 Plant growth and agronomic yields
10.5 Nanomaterials
10.6 Uses and applications
10.7 Pesticides, fertilizers, and nanobiosensors
10.8 Exposure, fate, and behavior
10.9 Interactions
10.10 Phytotoxicity
10.11 Hazard potentials
10.12 Current status and challenges
Further reading
Chapter 11. Environmental and eco-system
Abstract
11.1 Introduction
11.2 Key points
11.3 Overview
11.4 Types of nanoparticles
11.5 Pathways in the environment
11.6 Fate and behavior in environmental
11.7 Fate and behavior in ecosystems
11.8 Eco-toxicity
11.9 Interactions with other pollutants
11.10 Food chain effects and secondary poisoning
11.11 Hazard evaluation
11.12 Environmental risk assessment strategy
11.13 Comments and remarks
References
Further reading
Index

Product details

No. of pages: 246
Language: English
Published: April 27, 2022
Imprint: Academic Press
eBook ISBN: 9780323906906
Paperback ISBN: 9780323903998

About the Author

P.K. Gupta

Prof. Dr. Gupta, Hon DSc, PGDCA, FACVT (USA), FAEB, FST, FASc AW, FNAVSc is an internationally known toxicologist having 48 years of experience in the field of teaching, research and research management. He has guided many post-graduate students for their thesis work in toxicology and was honored with several National and International Awards including best teachers, best researcher, Alarsin award, Lifetime achievements, and IUTOX-Astra Zeneca Award (USA). To his credit he has several books, book chapters (Elsevier, Academic Press, John Wiley, Merck Manual etc) as well as scientific research publications (550) published in National and International peer reviewed Journals of repute. His contribution in the publication of Indian Veterinary Pharmacopeia is highly praise worthy. He is the founder Editor-in-Chief of a peer reviewed scientific journal “Toxicology International”, and Book Review Editor, Marcel Dekker, USA; Expert member Consultant and Advisor to WHO, Geneva; Consultant United Nations FAO, Rome; IAEA, Vienna; Founder Academy of Sciences for Animal Welfare; Founder and Past President, Society of Toxicology of India; Adjunct Professor, SRMS; founder director and member nominating committee of International Union of Toxicology; founder President of Society of Toxicology of India, and has held several prominent positions of scientific organizations in India and abroad.

In addition to this Dr Gupta has also been biographer in several WHO's WHO from all over the world including Marquis WHOs WHO (USA), IBC (UK) and other leading publications of the World. .At present Dr Gupta is a Director of Toxicology Consultant Group, Patron and Founder President of the Society of Toxicology of India, and President of the Academy of Sciences for Animal Welfare.

Affiliations and Expertise

Director of Toxicology Consultant Group, Patron and Founder President of the Society of Toxicology of India and President of the Academy of Sciences for Animal Welfare, Rajendra Nagar, Bareilly (UP), India

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