Fundamentals of Forensic DNA Typing

Fundamentals of Forensic DNA Typing

1st Edition - August 20, 2009

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  • Author: John Butler
  • eBook ISBN: 9780080961767
  • Paperback ISBN: 9780123749994

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Fundamentals of Forensic DNA Typing is written with a broad viewpoint. It examines the methods of current forensic DNA typing, focusing on short tandem repeats (STRs). It encompasses current forensic DNA analysis methods, as well as biology, technology and genetic interpretation. This book reviews the methods of forensic DNA testing used in the first two decades since early 1980’s, and it offers perspectives on future trends in this field, including new genetic markers and new technologies. Furthermore, it explains the process of DNA testing from collection of samples through DNA extraction, DNA quantitation, DNA amplification, and statistical interpretation. The book also discusses DNA databases, which play an important role in law enforcement investigations. In addition, there is a discussion about ethical concerns in retaining DNA profiles and the issues involved when people use a database to search for close relatives. Students of forensic DNA analysis, forensic scientists, and members of the law enforcement and legal professions who want to know more about STR typing will find this book invaluable.

Key Features

  • Includes a glossary with over 400 terms for quick reference of unfamiliar terms as well as an acronym guide to decipher the DNA dialect
  • Continues in the style of Forensic DNA Typing, 2e, with high-profile cases addressed in D.N.A.Boxes-- "Data, Notes & Applications" sections throughout
  • Ancillaries include: instructor manual Web site, with tailored set of 1000+ PowerPoint slides (including figures), links to online training websites and a test bank with key


Undergraduate forensic science students, lawyers who need enough cursory information to understand and speak to jury, law enforcement, crime scene investigators, legal professionals and government/legal policy makers.

Table of Contents

  • Foreword



    About the Author

    Chapter 1 Overview and History of DNA Typing

    Chapter 2 Basics of DNA Biology and Genetics

    Chapter 3 Historical Methods

    Chapter 4 Sample Collection, Storage, and Characterization

    Chapter 5 DNA Extraction

    Chapter 6 DNA Quantitation

    Chapter 7 DNA Amplification (The Polymerase Chain Reaction)

    Chapter 8 Short Tandem Repeat Markers

    Chapter 9 Fundamentals of DNA Separation and Detection

    Chapter 10 STR Genotyping and Data Interpretation

    Chapter 11 Statistical Interpretation: Evaluating the Strength of Forensic DNA Evidence

    Chapter 12 DNA Databases

    Chapter 13 Quality Assurance

    Chapter 14 Forensic Challenges: Degraded DNA, Mixtures, and LCN

    Chapter 15 Additional Loci and Nonhuman DNA Testing

    Chapter 16 Lineage Markers: Y Chromosome and mtDNA Testing

    Chapter 17 Applications of DNA Typing

    Chapter 18 Future Trends

    Appendix 1 Glossary of Terms

    Appendix 2 Useful Web Sites

    Appendix 3 Probability and Statistics


    References are provided at the end of each chapter by subtopic (but without direct

    citation within the text).

    High-profile cases and other interesting information are included as D.N.A. (Data,

    Notes, and Applications) boxes scattered throughout the book in the chapter pertaining

    to a particular subject.

Product details

  • No. of pages: 520
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: August 20, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080961767
  • Paperback ISBN: 9780123749994

About the Author

John Butler

John M. Butler is a NIST Fellow and Special Assistant to the Director for Forensic Science, Office of Special Programs, at the U.S. National Institute of Standards and Technology, in Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has won numerous scientific awards, including being named Science Watch’s #1 world-wide high-impact author in legal medicine and forensic science over the last decade (July 2011). He has over 150 publications in this field and is a frequent presenter on the topic of DNA typing, and has authored four other DNA Typing books including Advanced Topics in Forensic DNA Typing: Methodology. For a detailed CV, visit

Affiliations and Expertise

National Institute of Standards and Technology, Gaithersburg, Maryland, USA

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