Fundamentals and Applications of Fourier Transform Mass Spectrometry - 1st Edition - ISBN: 9780128140130

Fundamentals and Applications of Fourier Transform Mass Spectrometry

1st Edition

Editors: Philippe Schmitt-Kopplin Basem Kanawati
Paperback ISBN: 9780128140130
Imprint: Elsevier
Published Date: 1st March 2019
Page Count: 1000
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Description

Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data.

Key Features

  • Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge
  • Includes details on ion sources, data processing, chemical analysis and imaging
  • Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis

Readership

Post-graduate students of analytical chemistry, scientists in the broad world of mass spectrometry, Industry co-workers in quality control and pharmaceutical chemistry as well as in environmental and petroleum chemical analysis. Biologists including microbiology staff working in the field of RNA/DNA and proteomics. Physicists and scientists working on the cutting edge of analytical and physical chemistry. Industry Sectors: Health care and life sciences, Quality Control & Analytical chemical trace analysis, Manufacturers of all mass spectrometers, Academics, Chemical analysts in petroleum companies

Table of Contents

Historical chapters
1. FTICRMS
A.Marschall
2. Orbitrap
A.Makarov

Fundamental/technology chapters
3. Fundamentals of Orbitrap
A. Makarov
4. Latest developments in ICR-FTMS
M. Easterling
5. Fundamentals of ICR-FT-MS Simulations in ICR
E. Nikolaev
6. Advanced fundamentals
Y. Tsybin
7. Data processing & Automation in ICR-FT-MS
A.Kanawati
8. Fundamentals of 2D-FTMS
P. O´Connor
9. Data processing in 2D-FTMS
Ch. Rolando
10. Ion Mobility and FTMS
F. Fernandes-Lima
11. Imaging FTMS
A. Walsh
12. LD-ICR-FT-MS
F. Aubriet
13. Single cell
Zenobi
14. Surface MS
Eberlin

Applications Chapters
15. Metabolomics
Schmitt-Kopplin
16.Geochemistry and FTMS
Gonsior, Koch
17. Environmental chemistry
Lebedev
18. Petroleomics
R. Rogers , A.Marschall
19. Catalysts
Schrader
20. Peptidomics and Proteomics
R. Zubarev
21. Structure biology
J. Chamot-Rooke
22. Gas Phase ion-molecule reactions / Inorganics
K. P. Wanczek
23. FTMS and Inorganics
Gross
24. DNA/RNA
Zelimir
25. Post translational modifications, Serum antibodies and immunochemistry
M. Przybylski
26. Carbohydrates Biomedical Analysis in FTMS
J. Peter-Katalinic
27. FTMS Swift Top-down Proteomics, MS/MS
S. Guan
28. Lipidomics in Orbitrap
A. Shevchenko
29. Astrochemistry and Astrobiology
A. Somogyi

Details

No. of pages:
1000
Language:
English
Copyright:
© Elsevier 2019
Published:
Imprint:
Elsevier
Paperback ISBN:
9780128140130

About the Editor

Philippe Schmitt-Kopplin

Dr. Schmitt-Kopplin’s research team performs tailored and comprehensive metabolomics in health and environment. He has a strong profile in analytical chemistry with integrated approaches combining (ultra)high resolution mass spectrometry, separation sciences, NMR-spectroscopy and bioinformatics for the description of complex molecular systems on a molecular level. His focus in the last decade was to implement ion cyclotron resonance Fourier transform mass spectrometry into applications for a rapid and robust tool for deep metabotyping and small molecules profiling. His interdisciplinary studies are related to important diseases linked to environmental factors and microbiome engineering such as in diabetes, asthma and allergies, probiotics, intestinal infections, and microbial pathogens.

Affiliations and Expertise

Helmholtz Zentrum, Munich, Germany; Institute for analytical Food Chemistry of the Technical University Munich, Germany

Basem Kanawati

Dr. Kanawati is a mass spectrometry scientist with longtime expertise in FT-ICR mass spectrometry, coordinating the 12T high field FT-ICR-MS research laboratory in Helmholtz Zentrum München, Germany. His main research field is in physical chemistry covering a wide range of topics from organic mass spectrometric and MS/MS studies to FTMS instrumental cell developments; quantum mechanical investigations on gas phase ionic electronic systems; elucidation of advanced fragmentation mechanisms of organic ions as well as ion-molecule reaction mechanisms; mass spectrometric investigations of organic aerosols using different external ionization sources; and physical simulation of ion trajectories in several ICR cell geometries. He developed several computer programs for automatic calibration of ultra-high resolution ICR-MS spectra as well as in-depth post-processing of FT-ICR-MS spectra for increasing signal sensitivity, identifying Fourier transformed FID leakage artifacts such as sinc-wiggles in MS-spectra and increasing the resolution through accurate peak centroid recognition. He also developed a synchronized automatic system control of autosamplers with the 12T FT-ICR-MS instrument through microcontroller based technology and thus increased the productivity of the high field FT-ICR-MS laboratory.

Affiliations and Expertise

Helmholtz Zentrum, Munich, Germany

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