Functional Neural Transplantation III, Volume 200

1st Edition

Primary and Stem Cell Therapies for Brain Repair, Part I

Serial Volume Editors: Stephen B. Dunnett Anders Bjorklund
Hardcover ISBN: 9780444595751
eBook ISBN: 9780444595881
Imprint: Elsevier
Published Date: 11th December 2012
Page Count: 448
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Table of Contents

Series Page


Chapter 1. Introduction (Part I)


Chapter 2. Transplantation in the future

1. Constraints

2. Future directions

Chapter 3. Ethical challenges for using human cells in clinical cell therapy

1. Introduction

2. Challenges, ethical, and others

3. Scientific challenges and ethics

4. Societal concerns: legal and economic issues

5. Meeting ethical challenges and three theses

6. Stages and stage-related challenges

7. Concluding remarks


Chapter 4. Banking stem cells for research and clinical applications


1. Introduction

2. What are cell banks and why are they important?

3. Banking cells for clinical application

4. Testing and characterization of cell banks

5. The international landscape and cell standardization

6. Conclusions and future perspectives


Chapter 5. Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation

1. Introduction

2. Survival of DA neurons in VM grafts

3. Differentiation and composition of VM grafts

4. Connectivity of VM grafts

5. Closing remarks


Chapter 6. Electrophysiological investigations of synaptic connectivity between host and graft neurons

1. Introduction

2. The desired functional phenotype: Electrophysiological properties of A9 dopaminergic neurons

3. In vivo versus in vitro grafting schemes

4. Electrophysiological properties of stem cell-derived dopaminergic neurons

5. Maturation versus functional integration

6. Correlations between functional integration and behavioral recovery

7. Pitfalls of assessing functional integration in grafting experiments

8. Concluding remarks and future perspectives</p


This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Key Features

  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist


Neuroscientists, psychologists, neurologists


No. of pages:
© Elsevier 2012
eBook ISBN:
Hardcover ISBN:

About the Serial Volume Editors

Stephen B. Dunnett Serial Volume Editor

Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington’s disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson’s disease.

Affiliations and Expertise

Cardiff University, Cardiff, UK

Anders Bjorklund Serial Volume Editor

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients

Affiliations and Expertise

Lund University, Lund, Sweden