From Cyclotrons To Cytochromes  - 1st Edition - ISBN: 9780123975805, 9780323142052

From Cyclotrons To Cytochromes

1st Edition

Essays in Molecular Biology and Chemistry

Editors: Nathan Kaplan
eBook ISBN: 9780323142052
Imprint: Academic Press
Published Date: 1st January 1982
Page Count: 903
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From Cyclotrons to Cytochromes: Essays in Molecular Biology and Chemistry focuses on the uses of the cyclotron and radioactive isotopes in molecular biology and chemistry. The book includes a tribute to Martin Kamen, who played an important role in the development of biochemical sciences in the United States, particularly through his research on the cyclotron. The text also documents research on isotopes carried out at the Radiation Laboratory of the University of California at Berkeley during the 1930s, as well as the role of radioactive carbon in bacterial metabolism and experimental work on cytochromes.
This volume is organized into six sections encompassing 54 chapters and begins with an overview of science and technology, and then discusses carbon-14 and its half-life. The next chapters discuss the chemistry and structure of cytochromes; the role of cytochromes and redox systems in photosynthesis; the biological aspects of phosphorylation and oxidation; and protein structure. The book also methodically explains the regulatory mechanisms and miscellaneous metabolic processes such as the metabolism of cyclic nucleotides and related compounds; biological functions of lactate dehydrogenase; and nucleotide excision repair of damaged DNA. The final chapter discusses the deamidation of asparagine and glutamine side chains when incorporated into polypeptide chains, with reference to the role of cryptic amidase active sites in catalyzing the process. This book is a valuable resource for biochemists and molecular biologists.

Table of Contents




A Letter

Everything I've Always Wanted to Know about Cytochromes but Did Not Dare to Ask

Some Memories, Some Joys

Science, Technology, and the Quality of Life


Isotopes at Berkeley in the Thirties

Why Is the Half-Life of 1 4C So Long

Two Isotopes Are Better than One

Tracers in Biology

Radioactive Carbon in Bacterial Metabolism: Something Old and Something New

The Reemergence of Positron-Emitting Isotopes as Tracers of Metabolism: A New Approach for Measuring Changes in Rates of Cellular Proliferation in Vivo

From CO2 to Acetate

From Glycine to Heme

Cytochromes: Chemistry and Structure

Chemical Evolution and Chemical Innovation

Cytochrome c1—An Inert Cytochrome

Cytochromes and Ferredoxins in Bacterial Electron Transport and Classification

The Structure and Catalytic Mechanisms of Cytochrome c

Investigation of Cytochromes at Subzero Temperatures

Reduction Kinetics of Chromatium vinosum Cytochrome c

Toward a Common Structural Concept for P-450 Heme Proteins

Thiobacillus novellus Cytochrome Oxidase

The Structure and Classification of Cytochrome c

Phosphorylation, Oxidation, and Photosynthesis

Fifty Years of ATP

Biological Phosphorylation,32P, and Fifty Years of ATP

Cytochromes and Redox Systems in Photosynthesis

The Comparative Biochemistry of Photosynthesis: Milestones in a Conceptual Zigzag

Studies on the Oxygen-Evolving System of Photosynthesis: Are There Nonlinear Misses?

Photophosphorylation after Single Turnover Light Flashes in Chromatophores from Rhodospirillum rubrum

Composition and Development of the Bacterial Photosynthetic Apparatus

Active Components Bound to the Chromatophore Membrane of Rhodospirillum rubrum

Studies on Carotenes in Bacterial Reaction Centers

The Relationship between Photosynthesis and Nitrogen Fixation Revisited

Nitrogenase: Preparative Methods as a Basis for New Investigative Approaches or When Less Cytochrome is Better

Structure and Function of Membrane-Bound Proteins from M. phlei

The Dopamine Hydroxylating System of Bovine Adrenal Chromaffin Granules

Protein Structure

Concerted Hydrogen Bond Changes in Protein Conformational Transitions

Prediction of the Secondary Structure of Proteins

Substrate Specificity and Characteristics of Alcohol Dehydrogenase and Other Human Liver ADH Isoenzymes

Intrinsic Binding Energy, Enzymatic Catalysis, and Coupled Vectorial Processes

Oxygen Inactivation and Stabilization of Azotobacter Nitrogenase

Regulatory Mechanisms and Metabolic Miscellany

Hormones of the Anterior Pituitary Gland

Saint-Agnes, Music, and Sporulation

Molecular Mechanisms and Function of Bioluminescence in Fishes

Regulation of Yeast Hexokinase Activity

Deacylation of Cellular Lipids: An Assay for Tumor Promoters

Metabolism of Cyclic Nucleotides and Related Compounds in Different Layers of the Retina

Biological Functions of Lactate Dehydrogenase

Some Observations on the Evolution of the Regulation of the de Novo Pathway for UMP Biosynthesis in Prokaryotes

The Purine Nucleotide Cycle in Brain

Similarity Analysis Based upon Ribosomal Protein Compositions in Rhodospirillaceae Family: Initiatory Trail

Nucleotide Excision Repair of Damaged DNA

Genetic Structure of a Plasmic Replicon

Definition of a Disease: Experimental Allergic Encephalomyelitis

Cryptic Amidase Active Sites Catalyze Deamidation in Proteins




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Academic Press
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About the Editor

Nathan Kaplan

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