Formulation Factors in Adverse Reactions

Formulation Factors in Adverse Reactions

Topics in Pharmacy

1st Edition - February 16, 1990

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  • Editors: A. T. Florence, E. G. Salole
  • eBook ISBN: 9781483183626

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Description

Topics in Pharmacy, Volume 1: Formulation Factors in Adverse Reactions focuses on the important aspect of drug therapy—the nature of the dosage form or its ingredients that adversely influence therapeutic outcome. This book discusses the adverse reactions to formulation excipients, immunological basis of allergic reactions to drugs, and adverse reactions to parenteral medication. The influence of the shape and size of solid medicines on esophageal transit, and effects of the physical characteristics of formulations on adverse reactions are also deliberated. This volume is intended for senior undergraduate and postgraduate students in pharmacy, medicine, nursing and allied health sciences, and practitioners in the field of drug therapy.

Table of Contents


  • Series Preface

    Preface

    List of Contributors

    1 Adverse Reactions to Excipients in Pharmaceutical Formulations

    Introduction: Excipients are Not Inactive

    Spectrum and Incidence of Excipient Reactions

    Coloring Agents

    Preservatives

    Sugars, Sweeteners and Flavors

    Components of Ointments, Creams and Other Topical

    Formulations

    Alcohols

    Problems and Possible Solutions

    References

    Recommended Further Reading

    2 Drug Allergy: Chemical and Pharmaceutical Aspects

    Introduction

    Immunochemical Mechanisms of Drug Allergy

    Routes Of Formation of Antigens from Drugs

    Conclusions

    References

    3 Adverse Reactions to Parenterals

    Introduction

    Excipients

    Particulates as a Cause of Adverse Reactions to Parenterals

    Administration of Parenterals

    Conclusions

    References

    Further Reading

    4 Adverse Reactions to the Transit of Oral Dosage Forms

    Introduction

    Drug-Induced Oesophageal Ulceration

    Factors Influencing Oesophageal Transit

    Drug Absorption After Delayed Oesophageal Transit

    Conclusions

    References

    5 Physical Properties of Formulations and Adverse Reactions to Medicines

    Introduction

    Ocular Medication

    Oral Dosage Forms

    Parenteral Therapy

    Aerosols

    Conclusions

    References

    Index


Product details

  • No. of pages: 134
  • Language: English
  • Copyright: © Butterworth-Heinemann 1990
  • Published: February 16, 1990
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483183626

About the Editors

A. T. Florence

E. G. Salole

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