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The second edition of Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, principles of forensic toxicology including pharmacokinetics, pharmacodynamics, drug interactions and toxicogenomics, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Also included in the second edition is a Unit focused on the forensic toxicology of individual drugs of abuse.
Includes significant emphasis on the fundamental principles and concepts of forensic toxicology
Provides students with an introduction to the core tenets of the discipline, focusing on the concepts, strategies, and methodologies utilized by professionals in the field
Coauthored by a forensic toxicologist with over 40 years of experience as a professor who has taught graduate courses in forensic and analytical toxicology and who has served as a consultant and expert witness in civil and criminal cases
Upper Level Undergraduate Students and beginning Graduate Students studying Forensic Toxicology and/or Forensic Chemistry
UNIT I: PRINCIPLES OF TOXICOLOGY
1. Principles of Pharmacokinetics
2. Principles of Pharmacodynamics
3. Drug Interactions
UNIT II: INTRODUCTION TO FORENSIC TOXICOLOGY
5. The development of forensic toxicology
6. The Duties and Responsibilities of Forensic Toxicologists
7. Forensic Toxicology Resources
8. The Laboratory
UNIT III: ANALYSIS
9. Analytical Strategy
10. Sample Handling
11. Storage Stability of Analytes
12. Analytical Samples
13. Sample Preparation
14. Methods of Detection, Identification, and Quantitation
15. Quality Assurance and Quality Control
16. Analytical Errors
UNIT IV: INTERPRETATION
17. Types of Interpretations
18. Factors that Influence the Interpretations of Analyte Concentration
UNIT V: REPORTING
UNIT VI: DRUGS OF ABUSE
UNIT VII: Cases in Toxicology
27. The Case of William Palmer
28. The Case of Marie Bernard
29. The Case of Claus von Bulow
30. Physician Poisoners
Appendix A. Glossary
- No. of pages:
- © Academic Press 2021
- 1st November 2021
- Academic Press
- Hardcover ISBN:
Dr. Nicholas T. Lappas, an Associate Professor Emeritus in the Department of Forensic Sciences at the George Washington University, has extensive experience and demonstrated expertise in both the teaching and practice of forensic toxicology. In 1975, Dr. Lappas, was one of the first two full time faculty members appointed to the faculty of the Department of Forensic Sciences at the George Washington University. Prior to this appointment, he was a forensic toxicologist in the Allegheny Coroner’s Office in Pittsburgh, Pennsylvania. At GWU, he developed the MFS program in forensic toxicology, through which he has mentored hundreds of students and taught several graduate courses, including Forensic Toxicology, Analytical Toxicology, Medicinal Chemistry and Forensic Serology. Dr. Lappas’ research interests have been focused on the development of analytical toxicology methods and the evaluation of factors that influence the interpretation of analytical toxicology results. His professional activities include serving as a forensic toxicology consultant in more than 500 criminal and civil cases and as an expert witness in more than 100 cases.
The George Washington University, Washington, DC, USA
Dr. Courtney Lappas, Professor of Biology and Biochemistry and Molecular Biology at Lebanon Valley College is a Molecular Pharmacologist who has extensive experience teaching and conducting biomedical research. Previously a Fellow at the National Institutes of Health, Dr. Lappas’ research interests focus on the utilization of novel pharmacological tools in the treatment and/or prevention of immunological pathologies. Dr. Lappas incorporates her experience in translational research into her teaching and mentoring in courses including Pharmacology, Immunology, Molecular Biology and Drugs and Society.
Lebanon Valley College, Annville, PA, USA
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