Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals - 1st Edition - ISBN: 9780128127339

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals

1st Edition

Progress in Fluorine Science Series

Editors: Gunter Haufe Frederic Leroux
Paperback ISBN: 9780128127339
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 500
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Table of Contents

Medicinal Aspects
1. Review on fluorine in Medicinal Chemistry
2. Microbial fluorination/18F-labeling
3. Risk Assessment of reactive metabolites in drug discovery
4. Bioisosteres in Drug Design
5. Fluorinated Mechanism-Based Inhibitors
6. Fluorine in the Pharmaceutical Industry / Bio-relevant Fluorinated N-Heterocycles
7. Polyfluorinated groups in Medicinal Chemistry
8. Application of Fluorine in Med Medicinal Chemistry
9. Physico-Chemical Properties and Biological Activity Of Fluorinated Compounds
10. Fluorinated GABA Analogues
11. Fluorinated Amino Acids In Protein Analytics, Photodynamic Cancer Therapy; Advanced Building Blocks for Drug Discovery
12. Fluorine effects in Drug Design
13. Hydrogen bonding in Drug Discovery / Fluorine local environment: from screening to drug design
14. Fluorosugars as Inhibitors of Bacterial Enzymes
15. Fluorinated Antibiotics
16. Antiimflamatory And Antimicrobial Agents
17. Late Stage Fluorination Applied In Drug Discovery
18. Fluorine in Drug Design (Anisols)

Agricultural Aspects
19. Fluorine in Modern Crop Protection
20. Alpha,alpha-Difluorosulfonylisoxazoline Herbicides
21. Value of Fluorine in Agriculture
22. Biodegradation vs. Biotransformation of Fluorosubstituted Aromatics (agro-chemicals)

Molecular Imaging Aspects
23. 19F MRI in medicine
24. 19F MRI for in vivo Cell Tracking
25. 18F
26. PET, Medical Imaging, Radiotracers
27. Integrin receptor imaging
28. Brain imaging, Neurology, 18F metabolite analysis
29. 18F-labeled Radiopharmaceuticals; Current Status of F-18-Trifluoroborate- and F-18-SiFA-Based Radiopharmaceuticals in PET
30. 18F-PET in Neuroimaging

Bioorthogonal labelling of medicinally relevant structures


Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, the fourth volume in Alain Tressaud’s Progress in Fluorine Science Series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. The Progress in Fluorine Science series covers emerging trends and research in the area. Edited by recognized experts, this book provides unique coverage of the wide ranging uses and implications of fluorine and fluorinated compounds

Topics covered include: medicinal monitoring and diagnosis; 19F MRI in medicine and for in vivo cell tracking; 18F-labeled radiopharmaceuticals; brain imaging and neurology; risk assessment of reactive metabolites in drug discovery; fluorine effects for drug design; pharmaceutical industry; photodynamic cancer therapy; and agricultural aspects (fluorine in modern crop protection, biodegradation vs. biotransformation). Edited by Alain Tressaud, immediate past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry, to bring valuable and varied content to this active field.

Key Features

  • Covers a wide range of topics—from organic and physical chemistry to pharmaceuticals, agrochemicals and medical diagnostics
  • Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings
  • Features contributions from a wealth of global experts
  • Presents the fourth volume in Alain Tressaud’s Progress in Fluorine Science Series


Chemists in foundational research as well as in industry


No. of pages:
© Academic Press 2019
Academic Press
Paperback ISBN:

Ratings and Reviews

About the Editors

Gunter Haufe Editor

Günter Haufe, Professor at Münster Univ., Germany is one of the top leading European scientists in the field of the synthesis of new active molecules in Bioorganics and to their applications in Medical Sciences. His researches are mainly devoted to the discovery of new and selective molecules, active against various illnesses, including cancer, heart arrhythmia, neurological diseases (more than 250 papers in peer-referred journals). He is Editor for Europe, Africa & Australia of the Journal of Fluorine Chemistry. He edited the book: “Fluorine and Health: Molecular Imaging, Biomedical Materials and Pharmaceuticals”, Elsevier, Amsterdam (2008). He is Fellow of the European Academy of Sciences (Brussels).

Affiliations and Expertise

Organic Chemistry Institute, University of Münster, Germany

Frederic Leroux Editor

Frederic Leroux is CNRS Research Director at the University of Strasbourg. He is Director of the joint CNRS-Bayer laboratory of organofluorine chemistry and deputy director of the molecular chemistry department (LCM) at the European School of Chemistry, Polymers and Material Sciences. His research is published in >95 peer-reviewed papers, 16 patents, 6 book chapters and presented by invitation at >80 (inter)national conferences. He is Fellow of the Royal Society of Chemistry (FRSC). He is also a member of the International Scientific Committee of the Moissan Prize (Fluorine Chemistry) and Coordinator of the French Fluorine Network. His scientific interest covers various fields, based on a fruitful interplay of several objectives (a) the synthesis of biologically relevant molecules, (b) asymmetric methodologies using organic and organometallic chemistry, (c) organofluorine chemistry and (d) application of the objectives to industrial problems, which led to strong industrial collaborations.

Affiliations and Expertise

University of Strasbourg, France