Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals - 1st Edition - ISBN: 9780128127339

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals

1st Edition

Progress in Fluorine Science Series

Editors: Gunter Haufe Frederic Leroux
Paperback ISBN: 9780128127339
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 500
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Table of Contents

  1. Emerging Fluorination Methods in Organic Chemistry Relevant for Life Science Application
    2. Fluorination Patterns in Small Alkyl Groups: Their Impact on Properties Relevant to Drug Discovery
    3. Polyfluorinated scaffolds in drug discovery
    4. Case Studies of Fluorine in Drug Discovery
    5. Recent development in fluorinated antibiotics
    6. Fluorosugars as inhibitors of bacterial enzymes
    7. Microbial metabolism of fluorinated drugs
    8. Influence of fluorination on alcohol hydrogen-bond donating properties
    9. Synthesis and Applications of Backbone-Fluorinated Amino Acids
    10. 19F-labelled Amino Acids for NMR Structure Analysis of membrane-bound peptides
    11. In vivo 19-Fluorine Magnetic Resonance Imaging
    12. Fluorine-18 radiolabeling of biologics
    13. Serotonin receptor imaging by [18F]-PET
    14. Organoboronates: Captors of 18F-fluoride for One-step Radiofluorination of Biomolecules
    15. Silicon-Fluoride-Acceptor-based 18F-Radiopharmaceuticals: From basic SiFA chemistry towards its clinical application
    16. Bio-relevant fluorine-containing N-heterocycles
    17. Recent applications of fluorine in crop protection – New discoveries originating from the unique heptafluoroisopropyl group
    18. The Role of Fluorine in the Design of Nicotinic Acetylcholine Receptor (nAChR) Competitive Modulators


Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud’s Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals, brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more.

Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field.

Key Features

  • Covers a wide range of topics - from organic and physical chemistry, to pharmaceuticals, agrochemicals and medical diagnostics
  • Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings
  • Features contributions from a wealth of global experts
  • Acts as the fourth volume in Alain Tressaud’s Progress in Fluorine Science


Chemists in foundational research as well as in industry


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© Academic Press 2019
Academic Press
Paperback ISBN:

Ratings and Reviews

About the Editors

Gunter Haufe Editor

Günter Haufe, Professor at Münster Univ., Germany is one of the top leading European scientists in the field of the synthesis of new active molecules in Bioorganics and to their applications in Medical Sciences. His researches are mainly devoted to the discovery of new and selective molecules, active against various illnesses, including cancer, heart arrhythmia, neurological diseases (more than 250 papers in peer-referred journals). He is Editor for Europe, Africa & Australia of the Journal of Fluorine Chemistry. He edited the book: “Fluorine and Health: Molecular Imaging, Biomedical Materials and Pharmaceuticals”, Elsevier, Amsterdam (2008). He is Fellow of the European Academy of Sciences (Brussels).

Affiliations and Expertise

Organic Chemistry Institute, University of Münster, Germany

Frederic Leroux Editor

Frederic Leroux is CNRS Research Director at the University of Strasbourg. He is Director of the joint CNRS-Bayer laboratory of organofluorine chemistry and deputy director of the molecular chemistry department (LCM) at the European School of Chemistry, Polymers and Material Sciences. His research is published in >95 peer-reviewed papers, 16 patents, 6 book chapters and presented by invitation at >80 (inter)national conferences. He is Fellow of the Royal Society of Chemistry (FRSC). He is also a member of the International Scientific Committee of the Moissan Prize (Fluorine Chemistry) and Coordinator of the French Fluorine Network. His scientific interest covers various fields, based on a fruitful interplay of several objectives (a) the synthesis of biologically relevant molecules, (b) asymmetric methodologies using organic and organometallic chemistry, (c) organofluorine chemistry and (d) application of the objectives to industrial problems, which led to strong industrial collaborations.

Affiliations and Expertise

University of Strasbourg, France