Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set

Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set

11th Edition - July 5, 2020
This is the Latest Edition
  • Authors: Gary Firestein, Ralph Budd, Sherine E Gabriel, Iain B McInnes, James O'Dell
  • eBook ISBN: 9780323639217
  • Hardcover ISBN: 9780323639200

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Through 10 outstanding editions, Kelley & Firestein’s Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference.

Table of Contents


    Part 1: Structure and Function of Bone, Joints, and Connective Tissue

    1. Biology of the Normal Joint, 1
    Carla R. Scanzello and Steven R. Goldring

    2. Synovium, 20
    Douglas J. Veale and Gary S. Firestein

    3. Cartilage and Chondrocytes, 34
    Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser

    4. Biology, Physiology, and Morphology of Bone, 60
    Aline Bozec, Anika Grüneboom, and Georg Schett

    5. Muscle: Anatomy, Physiology, and Biochemistry, 67
    Mark S. Miller, Edward P. Debold, and Michael J. Toth

    6. Biomechanics, 80
    Kenton R. Kaufman and KaiNan An

    7. Regenerative Medicine and Tissue Engineering, 92
    Frank P. Luyten, Cosimo De Bari, and Francesco Dell’Accio

    8. Proteinases and Matrix Degradation, 109
    Yoshifumi Itoh

    Part 2: Cells Involved in Autoimmune Diseases and Inflammation

    9. Dendritic Cells, 132
    Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj

    10. Mononuclear Phagocytes, 149
    Deborah R. Winter, Anna Montgomery, and Harris Perlman

    11. Neutrophils, 161
    Binita Shah, Nathalie Burg, and Michael H. Pillinger

    12. T Lymphocytes, 182
    Ralph C. Budd

    13. B Cells, 199
    Yong-Rui Zou, Christine Grimaldi, and Betty Diamond

    14. Fibroblasts and Fibroblast-like Synoviocytes, 222
    Christopher D. Buckley and Andrew Filer

    15. Mast Cells, 241
    Peter A. Nigrovic

    16. Innate Lymphoid Cells and Natural Killer Cells, 254
    Michael A. Paley and Wayne M. Yokoyama

    17. Platelets and Megakaryocytes, 262
    Eric Boilard and Peter A. Nigrovic

    Part 3: Effector Mechanisms in Autoimmunity and Inflammation

    18. Principles of Signaling, 273
    Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos

    19. The Immunologic Repercussions of Cell Death, 286
    Helen M. Beere and Douglas R. Green

    20. Innate Immunity, 306
    Gregoire Lauvau and Steven A. Porcelli

    21. Adaptive Immunity, 320
    Martha S. Jordan and Gary A. Koretzky

    22. Autoimmunity and Tolerance, 337
    Dwight H. Kono and Argyrios N. Theofilopoulos

    23. The Microbiome in Health and Disease, 355
    Rob Knight

    24. Metabolic Regulation of Immunity, 368
    Ruoning Wang, Tingting Wang, and Stephen Tait

    25. Genetics of Rheumatic Diseases, 378
    Stephen Eyre and Anne Barton

    26. Epigenetics of Rheumatic Diseases, 393
    Amr H. Sawalha and Matlock A. Jeffries

    27. Complement System, 409
    V. Michael Holers and Leendert A. Trouw

    28. Prostaglandins, Leukotrienes, and Related Compounds, 420
    Robert B. Zurier

    29. Chemokines and Cellular Recruitment, 437
    Gerard Graham

    30. Angiogenesis, 445
    Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale

    31. Cytokines, 455
    Iain B. McInnes

    32. Experimental Models for Rheumatoid Arthritis, 467
    Rikard Holmdahl

    33. Neuronal Regulation of Pain and Inflammation, 480
    Camilla I. Svensson and Linda S. Sorkin

    Part 4: Broad Issues in the Approach to Rheumatic Disease

    34. Clinical Research Methods in Rheumatic Disease, 495
    Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag

    35. Economic Impact of Arthritis and Rheumatic Conditions, 510
    Louise B. Murphy

    36. Assessment of Health Outcomes, 522
    Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell

    37. Biomarkers in Rheumatology, 536
    Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan

    38. Occupational and Recreational Musculoskeletal Disorders, 551
    Richard S. Panush

    39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563
    Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb

    40. Cancer Risk in Rheumatic Diseases, 579
    Eric L. Matteson

    41. Introduction to Physical Medicine and Rehabilitation, 592
    Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke

    42. Pregnancy and Rheumatic Diseases, 604
    Lisa R. Sammaritano and Bonnie L. Bermas

    Part 5: Evaluation of Generalized and Localized Symptoms

    43. History and Physical Examination of the Musculoskeletal System, 621
    John M. Davis III, Kevin G. Moder, and Gene G. Hunder

    44. Ultrasound in Rheumatology, 638
    Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella

    45. Evaluation of Monoarticular and Polyarticular Arthritis, 663
    Ronald F. van Vollenhoven

    46. Skin and Rheumatic Diseases, 678
    David F. Fiorentino and Victoria P. Werth

    47. The Eye and Rheumatic Diseases, 702
    James T. Rosenbaum

    Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal  Pain

    48. Neck Pain, 711
    Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng

    49. Shoulder Pain, 727
    Scott David Martin and Thomas S. Thornhill

    50. Low Back Pain, 753
    Rajiv Dixit

    51. Hip and Knee Pain, 776
    James I. Huddleston, III, and Stuart Goodman

    52. Foot and Ankle Pain, 792
    Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan

    53. Hand and Wrist Pain, 800
    Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart

    54. Temporomandibular Joint Pain, 813
    Daniel M. Laskin

    55. Fibromyalgia, 825
    Leslie J. Crofford

    Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases

    56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841
    Hani S. El-Gabalawy and Stacy Tanner

    57. Arthrocentesis and Injection of Joints and Soft Tissues, 859
    Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield

    58. Anti-nuclear Antibodies, 875
    Stanford L. Peng and Joseph E. Craft

    59. Autoantibodies in Rheumatoid Arthritis, 890
    Erika Darrah, Antony Rosen, and Felipe Andrade

    60. Acute Phase Reactants, 907
    Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena

    61.Imaging in Rheumatic  Diseases,  920
    Mikkel Østergaard, Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert

    Part 8:  Pharmacology of Anti-rheumatic Drugs

    62. Therapeutic Targeting of Prostanoids, 965
    Leslie J. Crofford

    63. Glucocorticoid Therapy, 985
    Marlies C. van der Goes and Johannes W.G. Jacobs

    64. Traditional DMARDs: Methotrexate, Lefl, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 1007
    Amy C. Cannella and James R. O’Dell

    65. Immunosuppressive Drugs, 1031
    Jacob M. van Laar

    66. Anti-cytokine Therapies,   1046
    Katharine McCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin

    67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, 1068
    Peter C. Taylor

    68. Intra-cellular Targeting Agents in Rheumatic Disease, 1091
    Virginia Reddy and Stanley Cohen

    69. Urate-Lowering Therapy, 1111
    Ted R. Mikuls

    70. Bisphosphonates, 1125
    Arthur C. Santora II and Kenneth G. Saag

    71. Analgesic Agents in Rheumatic Disease, 1135
    Gregory R. Polston and Mark S. Wallace

    72. Nutrition and Rheumatic Diseases, 1156
    Lisa K. Stamp and Leslie G. Cleland

    73. Evaluation and Management of Early Undifferentiated Arthritis, 1173
    Karim Raza


    Part 9:  Rheumatoid Arthritis

    74. Etiology of Rheumatoid Arthritis, 1181
    Gary S. Firestein

    75. Pathogenesis of Rheumatoid Arthritis, 1200
    Gary S. Firestein

    76. Clinical Features of Rheumatoid Arthritis, 1236
    Bryant R. England and Ted R. Mikuls

    77. Treatment of Rheumatoid Arthritis, 1258
    James R. O’Dell

    78. Sjögren’s Syndrome, 1284
    E. William St. Clair and David L. Leverenz

    Part 10: Spondyloarthritis

    79. Etiology and Pathogenesis of Spondyloarthritis, 1307
    Keith A. Sikora and Robert A. Colbert

    80. Ankylosing Spondylitis and Other Forms of Axial Spondyloarthritis,  1319
    Sjef van der Linden, Matthew Brown, Lianne S. Gensler, Tony Kenna, Walter P. Maksymowych, and William J. Taylor

    81. Reactive Arthritis, 1344
    John D. Carter and Alan P. Hudson

    82. Psoriatic Arthritis, 1359
    Oliver FitzGerald and Conor Magee

    83. Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic Arthropathies, 1381
    Richard Zamore, Meenakshi Bewtra, and Alexis Ogdie

    Part 11: Systemic Lupus Erythematosus and Related Syndromes

    84. Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1396
    Mary K. Crow

    85. Clinical Features of Systemic Lupus Erythematosus, 1413
    Maria Dall’Era and David Wofsy

    86. Treatment of Systemic Lupus Erythematosus, 1437
    Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas

    87. Antiphospholipid Syndrome, 1460
    Medha Barbhaiya, Jane E. Salmon, and Doruk Erkan

    Part 12: Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes

    88. Etiology and Pathogenesis of Systemic Sclerosis, 1473
    John Varga

    89. Clinical Features and Treatment of Scleroderma, 1499
    Fredrick M. Wigley and Francesco Boin

    90. Inflammatory Diseases of Muscle and Other Myopathies, 1539
    Kanneboyina Nagaraju, Rohit Aggarwal, and Ingrid E. Lundberg

    91. Overlap Syndromes, 1569
    Jonathan Graf

    Part 13:  Vasculitis

    92. Classification and Epidemiology of Systemic Vasculitis, 1584
    Rennie L. Rhee and Peter A. Merkel

    93. Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis, 1595
    David B. Hellmann

    94. Anti-neutrophil Cytoplasmic Antibody– Associated Vasculitis, 1617
    Sharon A. Chung and Paul A. Monach

    95. Polyarteritis Nodosa and Related Disorders, 1634
    Raashid Luqmani and Abid Awisat

    96. Immune Complex–Mediated Small Vessel Vasculitis, 1649
    John H. Stone

    97. Primary Angiitis of the Central Nervous System, 1659
    Rula A. Hajj-Ali and Carol A. Langford

    98. Behçet’s Disease, 1666
    Christine S. Ahn, Lindsay C. Strowd, and Joseph L. Jorizzo

    Part 14: Crystal-Induced and Inflammasome- Mediated Inflammation

    99. Pathogenesis of Inflammasome-Mediated Diseases, 1676
    Hal M. Hoffman and Lori Broderick

    100. Etiology and Pathogenesis of Hyperuricemia and Gout, 1687
    Robert T. Keenan, Michael Toprover, and Michael H. Pillinger

    101. Clinical Features and Treatment of Gout, 1710
    Nicola Dalbeth

    102. Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate, 1732
    Robert Terkeltaub

    103. Familial Autoinflammatory Syndromes, 1752
    Catharina M. Mulders-Manders, Anna Simon, and Jos W.M. van der Meer

    Part 15: Cartilage, Bone, and Heritable Connective Tissue Disorders

    104. Pathogenesis of Osteoarthritis, 1770
    Paul E. Di Cesare, Dominik R. Haudenschild, Steven B. Abramson, and Jonathan Samuels

    105. Clinical Features of Osteoarthritis, 1789
    Amanda E. Nelson

    106. Treatment of Osteoarthritis, 1803
    Devyani Misra, Deepak Kumar, and Tuhina Neogi

    107. Metabolic Bone Disease, 1819
    Nancy E. Lane

    108. Proliferative Bone Diseases, 1839
    Reuven Mader

    109. Osteonecrosis, 1852
    Christopher Chang, Adam Greenspan, and M. Eric Gershwin

    110. Relapsing Polychondritis, 1876
    Gaye Cunnane

    111. Heritable Diseases of Connective Tissue, 1886
    Deborah Krakow

    Part 16: Rheumatic Diseases of Childhood

    112. Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, 1905
    Edward M. Behrens

    113. Clinical Features and Treatment of Juvenile Idiopathic Arthritis, 1911
    Joyce J. Hsu, Tzielan C. Lee, and Christy I. Sandborg

    114. Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus, 1931
    Stacy P. Ardoin and Fatima Barbar-Smiley

    115.Juvenile Dermatomyositis, Scleroderma, Vasculitis, and Autoimmune Brain Disease,  1942
    Angela B. Robinson, Jeffrey Dvergsten, Kathryn S. Torok, Heather Van Mater, William Gallentine, and Ann M. Reed

    Part 17: Infection and Arthritis

    116. Bacterial Arthritis, 1979
    Paul P. Cook and Dawd S. Siraj

    117. Lyme Disease, 1994
    Linda K. Bockenstedt

    118. Mycobacterial Infections of Bones and Joints, 2009
    Eric M. Ruderman and John P. Flaherty

    119. Fungal Infections of Bones and Joints, 2022
    Eric M. Ruderman and John P. Flaherty

    120. Rheumatic Manifestations of HIV Infection, 2033
    Jonathan Dau and John D. Reveille

    121. Viral Arthritis, 2048
    Philippe Gasque and Xavier Guillot

    122. Rheumatic Fever and Post-streptococcal Arthritis, 2061
    Luiza Guilherme, Pedro Ming Azevedo, and Jorge Kalil

    Part 18: Arthritis Accompanying Systemic Disease

    123. Amyloidosis, 2077
    Helen J. Lachmann and Faye A. Sharpley

    124. Sarcoidosis, 2088
    Peter Korsten, Nadera J. Sweiss, and Robert P. Baughman

    125. Hemochromatosis, 2105
    Gaye Cunnane

    126. Hemophilic Arthropathy, 2115
    Astrid E. Pulles, Lize F. D. van Vulpen, and Floris P.J.G. Lafeber

    127. Rheumatic Manifestations of Hemoglobinopathies,  2127
    Carlos J. Lozada and Elaine C. Tozman

    128. IgG4-Related Disease, 2135
    John H. Stone and Shiv Pillai

    129. Arthritis Accompanying Endocrine and Metabolic Disorders, 2149
    Sebastian E. Sattui and Joseph A. Markenson

    130. Rheumatic  Paraneoplastic  Syndromes—Links Between Malignancy and Autoimmunity, 2161
    Bernhard Manger and Georg Schett

    131. Tumors and Tumor-like Lesions of Joints and Related Structures, 2167
    Darcy A. Kerr and Andrew E. Rosenberg

    132. Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer, 2189
    Laura C. Cappelli, Clifton O. Bingham III, and Ami A. Shah

    Index, I-1








Product details

  • No. of pages: 2400
  • Language: English
  • Copyright: © Elsevier 2020
  • Published: July 5, 2020
  • Imprint: Elsevier
  • eBook ISBN: 9780323639217
  • Hardcover ISBN: 9780323639200

About the Authors

Gary Firestein

Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004).

Affiliations and Expertise

Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical & Translational Research Institute

Ralph Budd

Affiliations and Expertise

Professor of Medicine and Microbiology and Molecular Genetics, Director, Vermont Center for Immunology and Infectious Diseases, University of Vermont College of Medicine Distinguished University Professor, The University of Vermont College of Medicine, Burlington, Vermont

Sherine E Gabriel

Affiliations and Expertise

Professor and Dean, Rutgers Robert Wood Johnson Medical School, CEO, Robert Wood Johnson Medical Group, Emeritus Professor, Mayo Clinic, New Brunswick, New Jersey

Iain B McInnes

Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees – he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade.

Affiliations and Expertise

Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

James O'Dell

James R. O’Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O’Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O’Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O’Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.

Affiliations and Expertise

Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska

About the Editor

Gary Koretzky

Gary Koretzky, MD, PhD is Professor of Medicine at Weill Cornell Graduate School. Dr. Koretzky’s research aims to better understand the signal transduction events that occur following engagement of the T cell antigen receptor. He has been continuously funded by the National Institutes of Health since establishing his independent research group, as the laboratory has expanded its interests to study more globally the molecular events important for immune cell development, differentiation and function. Dr. Koretzky has published more than 200 research articles. He is a past President of the American Society of Clinical Investigation (2000) and Councilor of the Association of American Physicians (2008-2012), is a Fellow of the American Association for the Advancement of Science (2004), a member of the Institute of Medicine of the National Academies (2008), a Fellow of the American Academy of Arts & Sciences (2012) and serves as the Editor-in-Chief of Immunological Reviews (2002-present).

Affiliations and Expertise

Vice Dean at Weill Cornell Medical College, Frank H.T. Rhodes Distinguished Professor of Cardiovascular Biology and Genetics.