Fidelity and Quality Control in Gene Expression

Fidelity and Quality Control in Gene Expression

1st Edition - January 25, 2012

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  • Editor: Assen Marintchev
  • eBook ISBN: 9780123864987

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Description

The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting.

Key Features

  • Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation
  • Special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Table of Contents

  • Preface
    Quality control in aminoacyl-tRNA synthesis
    I. Introduction
    II. Class I aaRS Editing Mechanisms
    III. Class II aaRS Editing Mechanisms
    IV. Nucleotide Determinants for Editing
    V. Trans-Editing Factors and Triple Sieves
    VI. Loss of Editing Function in aaRS
    VII. Mistranslation and Role of Editing in Cell
    Acknowledgment
    Termination and post-termination events in eukaryotic translation
    I. Introduction
    II. Termination
    III. Ribosome Recycling
    IV. Reinitiation
    Acknowledgments
    Quality control of mRNA decoding on the bacterial ribosome
    I. Introduction
    II. Speed and Fidelity of Translation in vivo
    III. Substrate Selection During Translation Initiation
    IV. Fidelity of Elongation
    V. Termination Fidelity
    VI. Conclusions
    Acknowledgments
    Control of gene expression by translational recoding
    I. Introduction
    II. Programmed −1 Ribosomal Frameshifting
    III. Programmed +1 Ribosomal Frameshifting
    IV. Selenocysteine and Pyrrolysine: The 21st and 22nd Amino Acids
    V. Termination Codon Readthrough
    VI. Summary
    Acknowledgments
    The tmRNA ribosome-rescue system
    I. Introduction
    II. tmRNA–SmpB and the Mechanism of trans-Translation
    III. Degradation of ssrA-Tagged Proteins and Truncated mRNA
    IV. tmRNA-Independent Ribosome-Rescue Pathways
    V. Origins of Nonstop mRNA in Bacteria
    VI. mRNA Cleavage Resulting from Translational Arrest
    VII. Other Determinants of tmRNA Activity
    VIII. Role of tmRNA in Physiology and the Regulation of Gene Expression
    IX. Concluding Remarks
    Acknowledgments
    Posttranscriptional recoding by RNA editing
    I. Introduction
    II. Machinery and Mechanism
    III. Impact of RNA Editing
    IV. Conclusions and Outlook

Product details

  • No. of pages: 272
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: January 25, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123864987

About the Series Volume Editor

Assen Marintchev

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