Fetal and Neonatal Physiology, 2-Volume Set

Fetal and Neonatal Physiology, 2-Volume Set

6th Edition - July 29, 2021

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  • Editors: Richard Polin, Steven Abman, David Rowitch, William Benitz
  • Hardcover ISBN: 9780323712842
  • eBook ISBN: 9780323712859

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Description

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application.

Table of Contents

  • Cover image
  • Title page
  • Disclaimer
  • Table of Contents
  • Copyright
  • Dedicated To
  • Contributors
  • Preface
  • VOLUME 1
  • Section I. Genetics and Embryology
  • 1. Basic Genetic Principles
  • 2. Epigenetics
  • 3. Basic Embryology
  • 4. Regulation of Embryogenesis
  • 5. The Extracellular Matrix in Development
  • 6. Angiogenesis
  • 7. Prenatal Diagnosis
  • Section II. Placenta and Intrauterine Environment
  • 8. Placental Development
  • 9. Regulation of the Placental Circulation
  • 10. Mechanisms of Transfer Across the Human Placenta
  • 11. Endocrine and Paracrine Function of the Human Placenta
  • 12. Intra-Amniotic Infection/Inflammation and the Fetal Inflammatory Response Syndrome
  • 13. Fetal Origins of Adult Disease: A Classic Hypothesis With New Relevance
  • 14. Placental Function in Intrauterine Growth Restriction
  • Section III. Developmental Pharmacology
  • 15. Basic Pharmacologic Principles
  • 16. Principles of Pharmacokinetics
  • 17. The Physiology of Placental Drug Disposition
  • 18. Pharmacogenomics
  • 19. Drug Distribution in Fetal Life
  • 20. Drug Transfer During Breastfeeding
  • Section IV. Intrauterine and Postnatal Growth
  • 21. Placental and Fetal Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
  • 22. Endocrine Factors Affecting Neonatal Growth
  • 23. Human Milk Composition and Function in the Infant
  • 24. Physiology of Lactation
  • Section V. Perinatal Iron, Mineral, and Vitamin Metabolism
  • 25. Fetal and Neonatal Iron Metabolism
  • 26. Fetal and Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
  • 27. Zinc in the Fetus and Neonate
  • 28. Vitamin A Metabolism in the Fetus and Neonate
  • 29. Vitamin E Nutrition in Pregnancy and the Newborn Infant
  • 30. Vitamin K Metabolism in the Fetus and Neonate
  • Section VI. Lipid Metabolism
  • 31. Maternal-Fetal Transfer of Lipid Metabolites
  • 32. Brown Adipose Tissue: Development and Function
  • 33. Lipids as an Energy Source for the Premature and Term Neonate
  • 34. Ketone Body Metabolism in the Neonate
  • 35. Long-Chain Polyunsaturated Fatty Acids in Neurodevelopment
  • Section VII. Carbohydrate Metabolism
  • 36. Glucose Metabolism in the Fetus and Newborn, and Methods for Its Investigation
  • 37. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
  • 38. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
  • 39. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development
  • Section VIII. Protein Metabolism
  • 40. General Concepts of Protein Metabolism
  • 41. Placental Transfer and Fetal Requirements of Amino Acids
  • Section IX. Thermoregulation
  • 42. Temperature Control in Newborn Infants
  • Section X. Skin
  • 43. Structure and Development of the Skin and Cutaneous Appendages
  • 44. Physiologic Development of the Skin
  • Section XI. Fetal and Neonatal Cardiovascular Physiology
  • 45. Cardiovascular Development
  • 46. Developmental Electrophysiology in the Fetus and Neonate
  • 47. Developmental Biology of the Pulmonary Vasculature
  • 48. Development of the Gastrointestinal Circulation in the Fetus and Newborn
  • 49. Physiology of Congenital Heart Disease in the Neonate
  • 50. Regulation of Cardiovascular Function During Fetal and Newborn Life
  • 51. Nutritional and Environmental Effects on the Fetal Circulation
  • 52. Mechanisms Regulating Closure of the Ductus Arteriosus
  • 53. Umbilical Circulation
  • 54. Fetal and Placental Circulation During Labor
  • Section XII. The Lung
  • 55. Normal and Abnormal Structural Development of the Lung
  • 56. Regulation of Alveolarization
  • 57. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
  • 58. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
  • 59. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
  • 60. Upper Airway Structure: Function, Regulation, and Development
  • 61. Regulation of Lower Airway Function
  • 62. Functional Development of Respiratory Muscles
  • 63. Mechanics of Breathing
  • 64. Pulmonary Gas Exchange in the Developing Lung
  • 65. Oxygen Transport and Delivery
  • 66. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
  • 67. Basic Mechanisms of Oxygen Sensing and Adaptation to Hypoxia
  • 68. Evaluation of Pulmonary Function in the Neonate
  • 69. Mechanisms of Neonatal Lung Injury
  • 70. Impaired Lung Growth After Injury in Preterm Lung
  • 71. Antenatal Factors That Influence Postnatal Lung Development and Injury
  • 72. Regulation of Pulmonary Circulation
  • Section XIII. Surfactant
  • 73. Historical Perspective
  • 74. Developmental Biology of Lung Stem Cells
  • 75. Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins
  • 76. Structure and Development of Alveolar Epithelial Cells
  • 77. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
  • 78. Antenatal Hormonal Therapy for Prevention of Respiratory Distress Syndrome
  • 79. Surfactant Treatment
  • 80. Genetics and Physiology of Surfactant Protein Deficiencies
  • Section XVI. Physiology of Gastrointestinal Tract in the Fetus and Neonate
  • 81. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
  • 82. Organogenesis of the Gastrointestinal Tract
  • 83. Development of Gastric Secretory Function
  • 84. Development of the Enteric Nervous System and Gastrointestinal Motility
  • 85. Development of the Endocrine and Exocrine Pancreas
  • 86. Digestive-Absorptive Functions in Fetuses, Infants, and Children
  • 87. The Developing Microbiome of the Fetus and Neonate: A Multiomic Approach
  • Section XV. Liver and Bilirubin Metabolism
  • 88. Organogenesis and Histologic Development of the Liver
  • 89. Bile Acid Metabolism During Development
  • 90. Fetal and Neonatal Bilirubin Metabolism
  • 91. Hereditary Contributions to Neonatal Hyperbilirubinemia
  • 92. Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia
  • VOLUME 2
  • Section XVI. The Kidney
  • 93. Development of the Kidney: Morphology and Mechanisms
  • 94. Functional Development of the Kidney in Utero
  • 95. Development and Regulation of Renal Blood Flow in the Neonate
  • 96. Postnatal Development of Glomerular Filtration Rate in Neonates
  • 97. Renal Transport of Sodium During Development
  • 98. Potassium Homeostasis in the Fetus and Neonate
  • 99. Role of the Kidney in Calcium and Phosphorus Homeostasis
  • 100. Transport of Amino Acids in the Fetus and Neonate
  • 101. Organic Anion Transport in the Developing Kidney
  • 102. Concentration and Dilution of Urine
  • 103. Urinary Acidification
  • 104. Response to Nephron Loss in Early Development
  • Section XVII. Fluid and Electrolyte Metabolism
  • 105. Fluid Distribution in the Fetusand Neonate
  • 106. Regulation of Acid-Base Balance in the Fetus and Neonate
  • Section XVIII. Developmental Hematopoiesis
  • 107. Developmental Biology of Hematopoietic Stem Cells
  • 108. Neutrophil Granulopoiesis and Homeostasis
  • 109. Developmental Erythropoiesis
  • 110. Developmental Megakaryopoiesis
  • Section XIX. Hemostasis
  • 111. Developmental Hemostasis
  • 112. Platelet–Vessel Wall Interactions
  • Section XX. Developmental Immunobiology
  • 113. Host Defense Mechanisms Against Bacteria
  • 114. Host Defense Mechanisms Against Fungi
  • 115. Host Defense Mechanisms Against Viruses
  • 116. T-Cell Development
  • 117. B-Cell Development
  • 118. Mononuclear Phagocyte System
  • 119. Normal and Abnormal Neutrophil Physiology in the Newborn
  • 120. The Complement System of the Fetus and Newborn
  • 121. Cytokines and Inflammatory Response in the Fetus and Neonate
  • 122. Immunology of Human Milk
  • 123. Neonatal Pulmonary Host Defense
  • Section XXI. Neurology
  • 124. Development of the Nervous System
  • 125. Mechanisms of Cell Death in the Developing Brain
  • 126. Development of the Blood-Brain Barrier
  • 127. Trophic Factor, Nutritional, and Hormonal Regulation of Brain Development
  • 128. Developmental Aspects of Pain
  • 129. Cerebellar Development—The Impact of Preterm Birth and Comorbidities
  • 130. Electroencephalography in the Preterm and Term Infant
  • 131. Intraventricular Hemorrhage in the Neonate
  • 132. Pathophysiology of Neonatal White Matter Injury
  • 133. Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection
  • 134. Neuroprotective Therapeutic Hypothermia
  • Section XXII. Special Sensory Systems in the Fetus and Neonate
  • 135. Early Development of the Human Auditory System
  • 136. Development of Olfaction and Taste in the Human Fetus and Neonate
  • Section XXIII. Musculoskeletal
  • 137. The Growth Plate: Embryologic Origin, Structure, and Function
  • 138. Ontogenesis of Striated Muscle
  • Section XXIV. Endocrine Function
  • 139. Hypothalamus: Neuroendometabolic Center
  • 140. Growth Factor Regulation of Fetal Growth
  • 141. Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn
  • 142. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant
  • 143. Development of the Hypothalamus-Pituitary-Adrenal Axis in the Fetus
  • 144. Fetal and Neonatal Adrenocortical Physiology
  • 145. Fetal and Neonatal Thyroid Physiology
  • Section XXV. Ovary and Testis
  • 146. Genetics of Sex Determination and Differentiation
  • 147. Differentiation of the Ovary
  • 148. Testicular Development and Descent
  • Section XXVI. Pathophysiology of Neonatal Diseases
  • 149. The Pathophysiology of Twin-Twin Transfusion Syndrome, Twin-Anemia Polycythemia Sequence, and Twin-Reversed Arterial Perfusion
  • 150. Physiology of Neonatal Resuscitation
  • 151. Pathophysiology of Neonatal Sepsis
  • 152. Pathophysiology of Neonatal Hypoglycemia
  • 153. Pathophysiology of Cardiomyopathies
  • 154. Pathophysiology of Persistent Pulmonary Hypertension ofthe Newborn
  • 155. Pathophysiology of Shock in theFetus and Neonate
  • 156. Pathophysiology of Apnea of Prematurity
  • 157. Pathophysiology of Respiratory Distress Syndrome
  • 158. Pathophysiology of Meconium Aspiration Syndrome
  • 159. Pathophysiology of Bronchopulmonary Dysplasia
  • 160. Pathophysiology of Ventilator-Dependent Infants
  • 161. Pathophysiology of Gastroesophageal Reflux
  • 162. Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis
  • 163. Pathophysiology of Kernicterus
  • 164. Pathophysiology of Neonatal AcuteKidney Injury
  • 165. Pathophysiology of Edema
  • 166. Pathophysiology of Retinopathy of Prematurity
  • 167. Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury
  • 168. Pathophysiology of Neonatal Acute Bacterial Meningitis
  • 169. Pathophysiology of NeuralTube Defects
  • 170. Pathophysiology of Preeclampsia
  • 171. Pathophysiology of Preterm Birth
  • 172. Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence
  • 173. Pathophysiology of Genetic Neonatal Disease
  • 174. Genetic Variants and Neonatal Disease
  • Index

Product details

  • No. of pages: 2040
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: July 29, 2021
  • Imprint: Elsevier
  • Hardcover ISBN: 9780323712842
  • eBook ISBN: 9780323712859

About the Editors

Richard Polin

Affiliations and Expertise

William T. Speck Professor of Pediatrics, College of Physicians and Surgeons, Columbia University; Director, Division of Neonatology, Morgan Stanley Children's Hospital of New York - Presbyterian, Columbia University Medical Center, New York, New York

Steven Abman

Affiliations and Expertise

Professor of Pediatrics, University of Colorado School of Medicine; Director, Pediatric Heart Lung Center, Children’s Hospital Colorado, Denver, Colorado

David Rowitch

Affiliations and Expertise

Professor of Pediatrics and Neurosurgery, Chief, Division of Neonatology, UCSF Benioff Children’s Hospital San Francisco, San Francisco, California

William Benitz

Affiliations and Expertise

Professor Emeritus, Stanford University, Division of Neonatal Medicine, Stanford, California

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