A Clinical Compendium

1st Edition - October 15, 2019

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  • Editors: Larry Edelstein, John Smythies, Peter Quesenberry, Denis Noble
  • eBook ISBN: 9780128160541
  • Paperback ISBN: 9780128160534

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Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomesin the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medicaldisciplines, as well as their role in cell-cell communication. It is intended to serve as a referencesource for clinicians, physicians, and research scientists who wish to gain insight into the mostrecent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine sinceantibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is amajor breakthrough in our understanding of how cells function.

Key Features

  • Provides readers with a broad and timely overview of exosomes in health and disease, closing
    with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck.
  • Summarizes the most recent laboratory and clinical findings on exosomes across numerous
    medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective
    investigative efforts
  • Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing
    a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing


Research scientists and clinicians across the disciplines noted in the sections below

Table of Contents

  • 1. Exosome Basic Mechanisms
    2. Methods for exosome isolation and characterization
    3. Exosomes, microvesicles, and their friends in solid tumors
    4. Hematologic malignancies: the exosome contribution in tumor progression
    5. Physiological and pathological functions of prostasomes: From basic research to clinical application
    6. The function and therapeutic use of exosomes in bacterial infections
    7. Emerging therapeutic roles of exosomes in HIV-1 infection
    8. Extracellular vesicles in parasitic disease
    9. Exosomes as intercellular communication messengers for cardiovascular and cerebrovascular diseases
    10. Exosomes in Cutaneous Biology and Dermatologic Disease
    11. Exosomes in Nephrology
    12. Extracellular vesicles in neurodegenerative disorders
    13. Extracellular vesicles in fibrotic diseases: New applications for fibrosis diagnosis and treatment
    14. Mechanisms of exosome-mediated immune cell crosstalk in inflammation and disease
    15. Exosomes in Metabolic Syndrome
    16. Potential Role of Exosomes In Reproductive Medicine And Pregnancy
    17. Exosomes in Respiratory Disease
    18. Exosomes in Retinal Diseases
    19. MSC-exosomes in regenerative medicine
    20. The potential of exosomes as theragnostics in various clinical situations
    21. Exosomes, Gemmules, Pangenesis and Darwin

Product details

  • No. of pages: 548
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: October 15, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128160541
  • Paperback ISBN: 9780128160534

About the Editors

Larry Edelstein

Lawrence R. Edelstein, Ph.D. is a neuroscientist and pharmaceutical industry consultant with research interests in multisensory convergence/integration (claustrum) and intercellular communication (exosomes, telocytes). His interest in exosomes was fueled by a theme issue he guest-edited with John Smythies and Denis Noble entitled “Epigenetic information-processing mechanisms in the brain” (2014; https://royalsocietypublishing.org/toc/rstb/369/1652). That undertaking proved to be the impetus for a series of peer-reviewed articles in which he and his colleagues theorized as to the whys and wherefores of the multifunctional roles played by seemingly omnipresent and phyla-agnostic exosomes. In addition, Dr. Edelstein is co-editor (along with John Smythies and Vilayanur S. Ramachandran, M.B.B.S., Ph.D., Hon. F.R.C.P.) of the book Claustrum - Structural, Functional and Clinical Neuroscience (2014; www.elsevier.com/books/the-claustrum/smythies/978-0-12-404566-8).

Affiliations and Expertise

President and Founder, Medimark Corporation, Del Mar, CA, USA

John Smythies

John Raymond Smythies, M.B. B.Chir., M.D., F.R.C.P., F.R.C. Psych. (1922-2019) was the Director of the Integrative Neuroscience Program in the Department of Psychology at the University of California San Diego. As a pre-eminent neuropsychiatrist and neuroscientist he made significant contributions to both these disciplines. Together with Humphry Osmond he developed the first biochemical theory of schizophrenia - the transmethylation hypothesis. This has recently come back into focus following the finding that DNA methylation is abnormal in schizophrenia. He made extensive contributions to knowledge in a number of fields including the neuropharmacology of psychedelic drugs; the functional neuroanatomy of synapses with particular regard to the role of synaptic plasticity, endocytosis and redox factors; the role in the brain of orthoquinone metabolites of catecholamines; and, in particular, theories of brain-consciousness relations. More recently he developed foundational hypotheses and theories specific to the function of exosomes, telocytes and the claustrum, and on epigenetic processes in information processing in the brain. Professor Smythies served as President of the International Society of Psychoneuroendocrinology from 1970-1974, Consultant to the World Health Organization from 1963-1968, and Editor of the International Review of Neurobiology from 1958-1991. He was elected a member of the Athenaeum in 1968. He held the positions of Professor Emeritus and the Charles Byron Ireland Professor of Psychiatric Research at the University of Alabama Medical Center at Birmingham, Visiting Scholar at the Center for Brain and Cognition, University of California San Diego, and Senior Research Fellow at the Institute of Neurology, University College London. He published over 240 scientific papers and sixteen books. https://en.wikipedia.org/wiki/John_Raymond_Smythies

Affiliations and Expertise

Former Director, Laboratory for Integrative Neuroscience, Center for Brain and Cognition, Department of Psychology, University of California, San Diego, La Jolla, CA, USA

Peter Quesenberry

Peter J. Quesenberry, M.D., is the Paul Calabresi Professor of Oncology at The Warren Alpert Medical School of Brown University. He received his medical degree from the University of Virginia, completed residency at University Hospital and Boston City Hospital in Boston, MA, and completed a Hematology/Oncology Fellowship at St. Elizabeth's Hospital. Professor Quesenberry is a leading investigator in stem cell biology and extracellular vesicle research. He was President of the International Society of Hematology, editor of the journal Experimental Hematology from 1990-1998 and the leukocyte editor for the Year Book of Hematology from 1987-1998. More recently he is a co-editor-in-chief for the Journal of Extracellular Vesicles.

Affiliations and Expertise

Paul Calabresi Professor of Oncology, Professor of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA

Denis Noble

Denis Noble, C.B.E., Ph.D., F.R.S. is a British biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004 and was appointed Professor Emeritus and co-Director of Computational Physiology. He is one of the pioneers of systems biology. Professor Noble developed the first viable mathematical model of the working heart in 1960 using his discovery, with his supervisor Otto Hutter, of two of the main cardiac potassium ion channels. These discoveries were published in Nature (1960) and The Journal of Physiology (1962). The work was later developed with Dick Tsien, Dario DiFrancesco, Don Hilgemann and others to become the canonical models on which more than 100 cardiac cell models are based today. He was elected President of the International Union of Physiological Sciences (IUPS) at its Congress in Kyoto in 2009 and was re-elected for a second term at the 2013 Congress in Birmingham, UK. He is the author of the first popular book on systems biology, The Music of Life, and his most recent lectures concern the implications for evolutionary biology. Professor Noble has published more than 500 papers and 11 books. https://en.wikipedia.org/wiki/Denis_Noble

Affiliations and Expertise

Emeritus Professor of Cardiovascular Physiology, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK

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