Description

Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in understanding the current state and future prospects of a particular field.

This volume on exchangers, in conjunction with a previous volume on cotransporters (volume 70), represents an up-to-date, systematic, and comprehensive review of all the major secondary active carrier proteins responsible for the absorption, secretion, and general transport of ions and solutes in mammalian organ systems and additional species. Each chapter is devoted to a specific transporter or a grouping of related transporters based on the well-recognized nomenclature of the SoLute Carrier (SLC) gene family. This book provides readers with the latest mechanistic information on the function and structure of specific transporters, as well as their history and physiological significance.

Key Features

  • Comprehensive review of all the major exchangers
  • Emphasis on protein mechanism with the most recent findings from functional and structural work
  • Authoritative work from experts in the field

Readership

Scientists and researchers in biochemistry and molecular and cellular biology

Table of Contents

  • Dedication
  • Preface
  • Contents of Previous Volumes
  • Chapter One: Structure, Function, and Trafficking of SLC4 and SLC26 Anion Transporters
    • Abstract
    • 1 Introduction
    • 2 Anion Exchanger 1 Structure and Function
    • 3 AE1 Biosynthesis and N-glycosylation
    • 4 Erythroid AE1 Protein Interactions
    • 5 Erythroid AE1-Associated Diseases
    • 6 Retention and Rescue of AE1 Mutants
    • 7 Kidney AE1 Biogenesis, Interactors, and Associated Pathologies
    • 8 SLC4 Family of Anion Transporters
    • 9 The SLC26 (SulP) Family of Anion Transporters
    • 10 Conclusions and Future Prospects
  • Chapter Two: Structural Dynamics and Regulation of the Mammalian SLC9A Family of Na+/H+ Exchangers
    • Abstract
    • Acknowledgments
    • 1 Introduction
    • 2 Basic Functional Properties: Substrates, Driving Forces and Kinetics of SLC9As
    • 3 Structural Organization and Dynamics of the TM Region of SLC9As
    • 4 SLC9As Exist as Asymmetrical Homodimers in the Membrane
    • 5 The SLC9A C-Terminal Tail: Structure/Disorder, Interaction Partners, and Phosphorylation
    • 6 Biophysics of SLC9A Function
    • 7 Regulation of SLC9A Turnover and Trafficking
    • 8 Conclusions, Perspectives, and Open Questions
  • Chapter Three: Vesicular Neurotransmitter Transporters: Mechanistic Aspects
    • Abstract
    • Acknowledgments
    • 1 Introduction
    • 2 Classification of Vesicular Neurotransmitter Transporters
    • 3 Neurotransmitter Transporters from the MFS
    • 4 Vesicular Inhibitory Amino Acid Transporter (SLC32)
  • Chapter Four: Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1
    • Abstract
    • Acknowledgment
    • 1 Introduction
    • 2 The Biological Roles of Folates and Therapy with Antifolates
    • 3 Reduced Folate Carr

Details

No. of pages:
438
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Electronic ISBN:
9780128002919
Print ISBN:
9780128002230

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