Evaluation of Drug Activities

Evaluation of Drug Activities

Pharmacometrics

1st Edition - January 1, 1964

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  • Editors: D R Laurence, A. L. Bacharach
  • eBook ISBN: 9781483263465

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Description

Evaluation of Drug Activities: Pharmacometrics, Volume 1 provides a review and critical discussion of general and special pharmacological methods used in the search of new drugs. This book discusses the fundamental difference between a pharmacological study and a bio-assay in the nature of the biological activity. Organized into two parts encompassing 19 chapters, this book begins with an overview of the pharmacological and toxicological studies on animals. This text then discusses the method of producing clinically successful drugs. Other chapters consider the objective of toxicity testing in determining the complications arising from the pharmacological action of the drug and also in discovering any unexpected side-effects. This book discusses as well the pharmacological effects and heredity in laboratory animals. The final chapter deals with the various aspects of hypertensive disease and its treatment. This book is a valuable resource for scientists, biologists, physiologists, pharmacologists, biochemists, physicians, clinicians, and research workers.

Table of Contents


  • List of Contributors

    Preface

    Symbols and Abbreviations

    Part I. General Principles

    Chapter 1. First Clinical Trials of Potential Drugs

    Chapter 2. A Plan for Evaluating Potential Drugs

    Chapter 3. Design, Statistical Analysis and Interpretation

    Chapter 4. Strain and Sex Differences ill Response to Drugs

    Chapter 5. Some Limitations of Animal Tests

    Chapter 6. Toxicity Tests

    Chapter 7. Drug Dependence

    Part II. Particular Applications

    Chapter 8. Analgesics

    Chapter 9. Local Anaesthetics

    Chapter 10. Tranquillisers and Sedatives

    Chapter 11. Antidepressives, Analeptics and Appetite Suppressants

    Chapter 12. Hypnotics and General Anaesthetics

    Chapter 13. Anticonvulsants

    Chapter 14. AntiParkinsonian Agents

    Chapter 15. Centrally Acting Skeletal Muscle Relaxants

    Chapter 16. Neuromuscular Blocking Agents

    Chapter 17. Cardiovascular Activity of Sympathomimetic Amines

    Chapter 18. Depressants of Peripheral Sympathetic Nerve Function

    Chapter 19. Antihypertensive Agents

    Chapter 20. Anticholinesterases

    Chapter 21. Histamine Antagonists

    Chapter 22. Selective Brain Stem Depressants: Antiemetics, Antitussives, Antihypertensives, Antipyretics

    Chapter 23. Agents Acting on the Alimentary Tract

    Chapter 24. Agents Acting on the Respiratory Tract

    Chapter 25. Iron-containing Haematinics

    Chapter 26. Coagulants and Anticoagulants

    Chapter 27. Cardioactive Agents

    Chapter 28. Diuretics and Antidiuretics

    Chapter 29. Biologically Active Polypeptides

    Chapter 30. Dermatological Agents

    Chapter 31. Agents acting on the Uterus

    Chapter 32. Oestrogens, Androgens and Progestagens

    Chapter 33. Adrenocorticoid Activity

    Chapter 34. Adrenocortical Antagonists

    Chapter 35. Thyroxine Analogues (Thyroxine Antagonists and Thyromimetics)

    Chapter 36. Antithyroid Agents

    Chapter 37. Hypoglycaemic Agents

    Chapter 38. Antifertility Agents

    Chapter 39. Anti-inflammatory Agents

    Chapter 40. Antitumour Agents

    Chapter 41. Blood Cholesterol Depressants

    Appendix Compositions of some Organ Bath Solutions

    Alphabetical Guide To Chapter Contents




Product details

  • No. of pages: 474
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483263465

About the Editors

D R Laurence

A. L. Bacharach

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