Evaluation of Drug Activities - 1st Edition - ISBN: 9781483228457, 9781483263465

Evaluation of Drug Activities

1st Edition

Pharmacometrics

Editors: D R Laurence A. L. Bacharach
eBook ISBN: 9781483263465
Imprint: Academic Press
Published Date: 1st January 1964
Page Count: 474
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Description

Evaluation of Drug Activities: Pharmacometrics, Volume 1 provides a review and critical discussion of general and special pharmacological methods used in the search of new drugs. This book discusses the fundamental difference between a pharmacological study and a bio-assay in the nature of the biological activity. Organized into two parts encompassing 19 chapters, this book begins with an overview of the pharmacological and toxicological studies on animals. This text then discusses the method of producing clinically successful drugs. Other chapters consider the objective of toxicity testing in determining the complications arising from the pharmacological action of the drug and also in discovering any unexpected side-effects. This book discusses as well the pharmacological effects and heredity in laboratory animals. The final chapter deals with the various aspects of hypertensive disease and its treatment. This book is a valuable resource for scientists, biologists, physiologists, pharmacologists, biochemists, physicians, clinicians, and research workers.

Table of Contents


List of Contributors

Preface

Symbols and Abbreviations

Part I. General Principles

Chapter 1. First Clinical Trials of Potential Drugs

Chapter 2. A Plan for Evaluating Potential Drugs

Chapter 3. Design, Statistical Analysis and Interpretation

Chapter 4. Strain and Sex Differences ill Response to Drugs

Chapter 5. Some Limitations of Animal Tests

Chapter 6. Toxicity Tests

Chapter 7. Drug Dependence

Part II. Particular Applications

Chapter 8. Analgesics

Chapter 9. Local Anaesthetics

Chapter 10. Tranquillisers and Sedatives

Chapter 11. Antidepressives, Analeptics and Appetite Suppressants

Chapter 12. Hypnotics and General Anaesthetics

Chapter 13. Anticonvulsants

Chapter 14. AntiParkinsonian Agents

Chapter 15. Centrally Acting Skeletal Muscle Relaxants

Chapter 16. Neuromuscular Blocking Agents

Chapter 17. Cardiovascular Activity of Sympathomimetic Amines

Chapter 18. Depressants of Peripheral Sympathetic Nerve Function

Chapter 19. Antihypertensive Agents

Chapter 20. Anticholinesterases

Chapter 21. Histamine Antagonists

Chapter 22. Selective Brain Stem Depressants: Antiemetics, Antitussives, Antihypertensives, Antipyretics

Chapter 23. Agents Acting on the Alimentary Tract

Chapter 24. Agents Acting on the Respiratory Tract

Chapter 25. Iron-containing Haematinics

Chapter 26. Coagulants and Anticoagulants

Chapter 27. Cardioactive Agents

Chapter 28. Diuretics and Antidiuretics

Chapter 29. Biologically Active Polypeptides

Chapter 30. Dermatological Agents

Chapter 31. Agents acting on the Uterus

Chapter 32. Oestrogens, Androgens and Progestagens

Chapter 33. Adrenocorticoid Activity

Chapter 34. Adrenocortical Antagonists

Chapter 35. Thyroxine Analogues (Thyroxine Antagonists and Thyromimetics)

Chapter 36. Antithyroid Agents

Chapter 37. Hypoglycaemic Agents

Chapter 38. Antifertility Agents

Chapter 39. Anti-inflammatory Agents

Chapter 40. Antitumour Agents

Chapter 41. Blood Cholesterol Depressants

Appendix Compositions of some Organ Bath Solutions

Alphabetical Guide To Chapter Contents




Details

No. of pages:
474
Language:
English
Copyright:
© Academic Press 1964
Published:
Imprint:
Academic Press
eBook ISBN:
9781483263465

About the Editor

D R Laurence

A. L. Bacharach