This special volume of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis.

Key Features

Key features:

* Contributions from leading authorities

* Informs and updates on all the latest developments in the field </P><BR>


Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer

Table of Contents


Chapter One. Dicer Proteins and Their Role in Gene Silencing Pathways

1. Introduction

2. Dicers: RNase III Family Members with a Role in Gene Silencing

3. Mechanism of Processing and the Role of the Catalytic RNase III Domains

4. Role of Other Domains in Dicer Function

5. Domain Arrangement in Metazoan Dicers

6. Inside-Out Processing Mechanism by the Yeast Dicer

7. Function of Dicer in the Nucleus

8. Proteins Interacting with Dicer and the Assembly of RISC Effector Complexes

9. Future Perspectives


Chapter Two. Loquacious, a Dicer Partner Protein, Functions in Both the MicroRNA and siRNA Pathways

1. Introduction

2. miRNA and siRNA Pathways in the Fruit Fly Drosophila melanogaster

3. Drosophila Dicer-1 and Dicer-2: Similar but Distinct Domain Structures

4. Conserved Partnerships Between Dicer and Dicer-Binding Partner dsRBD Proteins

5. loqs Encodes Four Alternatively Spliced Isoforms

6. Loqs-PA and Loqs-PB Bind to Dicer-1, While Loqs-PD and R2D2 Bind to Dicer-2

7. Partner Protein Mutant Phenotypes in Flies and Mammals

8. Loqs-PA and Loqs-PB Function in the miRNA Pathway

9. Loqs-PD Functions in the siRNA Pathway

10. Loqs-PB Is Required to Maintain Ovarian Germline Stem Cells

11. For Some miRNAs, Loqs-PB Tunes Mature miRNA Length

12. Future Directions

13. Concluding Remarks


Chapter Three. Translin: TRAX Complex (C3PO), a Novel Ribonuclease for the Degradation of Small RNAs

1. Introduction: Earlier Studies of Translin and TRAX

2. Discovery of C3PO as a Novel Endoribonuclease Involved in the Activation of RNA-Induced Silencing Complex

3. C3PO Ribonuclease in tRNA Processing

4. Structure of C3PO: An Unusual Asymmetrical Hetero-Octamer

5. Oligomeric States of C3PO and Implications for Subst


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© 2012
Academic Press
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