Essentials of Stem Cell Biology
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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
Key Features
- Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
- Contributions by Nobel Laureates and leading international investigators
- Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough
- Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate
- Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references
Readership
researchers, grad students, and professionals working with human stem cells in biology, tissue engineering, genetics, cancer research, virology, immunology, and biotechnology
Table of Contents
- FOREWORD
Why Stem Cell Research?
A New Path ?{ Induced Pluripotent Stem Cells
Embryonic Stem Cells Versus Adult Stem Cells
'Stemness': Definitions, Criteria and Standards
PART ONE
INTRODUCTION TO STEM CELLS
1. Present Perspective and Future Challenges
2. Embryonic Stem Cells in Perspective
3. The Development of Epithelial Stem Cell Concepts
4. The Advent of Direct Reprogramming
5. Clinical Translation of Stem Cells
PART TWO
BASIC BIOLOGY/MECHANISMS
6. Molecular Basis of Pluripotency
7. Stem Cell Niches
8. Mechanisms of Stem Cell Self-Renewal
9. Cell Cycle Regulators in Stem Cells
10. Epigenetic Mechanisms of Cellular Memory
11. Cell Fusion and the Differentiated State
12. How Cells Change Their Phenotype
PART THREE
TISSUE AND ORGAN DEVELOPMENT
13. Differentiation in Early Development
14. Primordial Germ Cells in Mouse and Human
15. Stem Cells in Extraembryonic Lineages
16. Amniotic Fluid Derived Pluripotent Cells
17. Cord Blood Stem Cells
18. Neurogenesis in the Vertebrate Embryo
19. The Nervous System
20. Neuronal Progenitors in the Adult Brain
21. Sensory Epithelium of the Eye and Ear
22. Epithelial Skin Stem Cells
23. The Ontogeny of the Hematopoietic System
24. Hematopoietic Stem Cells
25. Red Blood Cells
26. Cell Differentiation in the Skeleton
27. Vascular Progenitor Cells
28. Multipotent Adult Progenitor Cells
29. Mesenchymal Stem Cells
30. Skeletal Muscle Stem Cells
31. Stem Cells and the Regenerating Heart
32. Potential of ES Cell Differentiation Culture for Vascular Biology
33. Cell Lineages and Stem Cells in the Kidney
34. Adult Liver Stem Cells
35. Pancreatic Stem Cells
36. Stem Cells in the Gastrointestinal Tract
37. Stem Cells in the Lung
PART FOUR
METHODS
38. Generation of Induced Pluripotent Stem Cells
39. Characteristics and Characterization of Pluripotent Stem Cells
40. Isolation and Maintenance of Murine Embryonic Stem Cells
41. Isolation, Characterization, and Maintenance of Primate ES Cells
42. Approaches for Derivation and Maintenance of Human ES cells:
Detailed Procedures and Alternatives
43. Derivation and Differentiation of Human EG Cells
44. Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells
45. Feeder-Free Culture
46. Genetic Manipulation of Human Embryonic Stem Cells
47. Homologous Recombination in Human Embryonic Stem Cells
48. Surface Antigen Markers
49. Lineage Marking
50. Genomic Reprogramming
51. Isolation and Characterization of Hematopoietic Stem Cells
52. Microarray Analysis of Stem Cells and Differentiation
53. Zebrafish and Stem Cell Research
PART FIVE
APPLICATIONS
54. Cancer Stem Cells
55. Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases
56. Spinal Cord Injury
57. Use of Embryonic Stem Cells to Treat Heart Disease
58. Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes
59. Burns and Skin Ulcers 978-0-12-370465-8
60. Stem Cells and Heart Disease
61. Stem Cells for the Treatment of Muscular Dystropy
62. Skin Regeneration
63. Orthopaedic Applications of Stem Cells
64. Embryonic Stem Cells in Tissue Engineering
65. Adult Stem Cells in Tissue Engineering
66. Stem Cell Gene Therapy
PART SIX
REGULATION AND ETHICS
67. Ethical Considerations
68. Religious Considerations
69. Regulatory Considerations
70. It¡¦s Not About Curiosity, It¡¦s About Cures
Epilogue: Concluding Statement
Product details
- No. of pages: 680
- Language: English
- Copyright: © Academic Press 2009
- Published: June 5, 2009
- Imprint: Academic Press
- eBook ISBN: 9780080884974
About the Editors
Robert Lanza
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.
Affiliations and Expertise
Astellas Institute for Regenerative Medicine, Westborough, MA, USA
John Gearhart
Affiliations and Expertise
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Brigid Hogan
Affiliations and Expertise
Duke University Medical Center, Durham, NC, USA
Douglas Melton
Affiliations and Expertise
Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA
Roger Pedersen
Affiliations and Expertise
Department of Surgery, University of Cambridge, Addenbrooke's Hospital, UK
E. Donnall Thomas
Affiliations and Expertise
Director Emeritus, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
James Thomson
Affiliations and Expertise
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA
Ian Wilmut
Sir Ian Wilmut is an embryologist who famously led the team that successfully cloned ‘Dolly the sheep’ in the mid-1990s. To achieve this technical feat, the team established a technique for transferring nuclei from adult sheep cells to unfertilized sheep eggs that had had their own nuclei removed. He now conducts research on adult cells, using techniques that avoid the need to obtain embryonic cells. Ian’s current work aims to convert skin cells into stem cells that have the ability to form all tissues. By deriving these cells from donors who have inherited degenerative diseases, it is possible to gain new understanding of how diseases arise and search for medicines that are able to prevent the degeneration. In the long run, stem cells will be used in new treatments. Ian is a strong advocate of a proposal to develop a global network of cell banks, making it possible for anyone in the world to have access to such cell therapy.
Affiliations and Expertise
Director, MRC Centre for Regenerative Medicine, Edinburgh, UK
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