Essentials of Stem Cell Biology

Essentials of Stem Cell Biology

2nd Edition - June 5, 2009

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  • Editors: Robert Lanza, John Gearhart, Brigid Hogan, Douglas Melton, Roger Pedersen, E. Donnall Thomas, James Thomson, Ian Wilmut
  • eBook ISBN: 9780080884974

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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

Key Features

  • Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
  • Contributions by Nobel Laureates and leading international investigators
  • Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough
  • Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate
  • Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references


researchers, grad students, and professionals working with human stem cells in biology, tissue engineering, genetics, cancer research, virology, immunology, and biotechnology

Table of Contents


    Why Stem Cell Research?
    A New Path ?{ Induced Pluripotent Stem Cells
    Embryonic Stem Cells Versus Adult Stem Cells
    'Stemness': Definitions, Criteria and Standards

    1. Present Perspective and Future Challenges
    2. Embryonic Stem Cells in Perspective
    3. The Development of Epithelial Stem Cell Concepts
    4. The Advent of Direct Reprogramming
    5. Clinical Translation of Stem Cells

    6. Molecular Basis of Pluripotency
    7. Stem Cell Niches
    8. Mechanisms of Stem Cell Self-Renewal
    9. Cell Cycle Regulators in Stem Cells
    10. Epigenetic Mechanisms of Cellular Memory
    11. Cell Fusion and the Differentiated State
    12. How Cells Change Their Phenotype

    13. Differentiation in Early Development
    14. Primordial Germ Cells in Mouse and Human
    15. Stem Cells in Extraembryonic Lineages
    16. Amniotic Fluid Derived Pluripotent Cells
    17. Cord Blood Stem Cells
    18. Neurogenesis in the Vertebrate Embryo
    19. The Nervous System
    20. Neuronal Progenitors in the Adult Brain
    21. Sensory Epithelium of the Eye and Ear
    22. Epithelial Skin Stem Cells
    23. The Ontogeny of the Hematopoietic System
    24. Hematopoietic Stem Cells
    25. Red Blood Cells
    26. Cell Differentiation in the Skeleton
    27. Vascular Progenitor Cells
    28. Multipotent Adult Progenitor Cells
    29. Mesenchymal Stem Cells
    30. Skeletal Muscle Stem Cells
    31. Stem Cells and the Regenerating Heart
    32. Potential of ES Cell Differentiation Culture for Vascular Biology
    33. Cell Lineages and Stem Cells in the Kidney
    34. Adult Liver Stem Cells
    35. Pancreatic Stem Cells
    36. Stem Cells in the Gastrointestinal Tract
    37. Stem Cells in the Lung

    38. Generation of Induced Pluripotent Stem Cells
    39. Characteristics and Characterization of Pluripotent Stem Cells
    40. Isolation and Maintenance of Murine Embryonic Stem Cells
    41. Isolation, Characterization, and Maintenance of Primate ES Cells
    42. Approaches for Derivation and Maintenance of Human ES cells:
    Detailed Procedures and Alternatives
    43. Derivation and Differentiation of Human EG Cells
    44. Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells
    45. Feeder-Free Culture
    46. Genetic Manipulation of Human Embryonic Stem Cells
    47. Homologous Recombination in Human Embryonic Stem Cells
    48. Surface Antigen Markers
    49. Lineage Marking
    50. Genomic Reprogramming
    51. Isolation and Characterization of Hematopoietic Stem Cells
    52. Microarray Analysis of Stem Cells and Differentiation
    53. Zebrafish and Stem Cell Research

    54. Cancer Stem Cells
    55. Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases
    56. Spinal Cord Injury
    57. Use of Embryonic Stem Cells to Treat Heart Disease
    58. Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes
    59. Burns and Skin Ulcers 978-0-12-370465-8
    60. Stem Cells and Heart Disease
    61. Stem Cells for the Treatment of Muscular Dystropy
    62. Skin Regeneration
    63. Orthopaedic Applications of Stem Cells
    64. Embryonic Stem Cells in Tissue Engineering
    65. Adult Stem Cells in Tissue Engineering
    66. Stem Cell Gene Therapy

    67. Ethical Considerations
    68. Religious Considerations
    69. Regulatory Considerations
    70. It¡¦s Not About Curiosity, It¡¦s About Cures
    Epilogue: Concluding Statement

Product details

  • No. of pages: 680
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: June 5, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080884974

About the Editors

Robert Lanza

Robert Lanza
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

Affiliations and Expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

John Gearhart

Affiliations and Expertise

Johns Hopkins University School of Medicine, Baltimore, MD, USA

Brigid Hogan

Affiliations and Expertise

Duke University Medical Center, Durham, NC, USA

Douglas Melton

Affiliations and Expertise

Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA

Roger Pedersen

Affiliations and Expertise

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, UK

E. Donnall Thomas

Affiliations and Expertise

Director Emeritus, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

James Thomson

Affiliations and Expertise

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

Ian Wilmut

Sir Ian Wilmut is an embryologist who famously led the team that successfully cloned ‘Dolly the sheep’ in the mid-1990s. To achieve this technical feat, the team established a technique for transferring nuclei from adult sheep cells to unfertilized sheep eggs that had had their own nuclei removed. He now conducts research on adult cells, using techniques that avoid the need to obtain embryonic cells. Ian’s current work aims to convert skin cells into stem cells that have the ability to form all tissues. By deriving these cells from donors who have inherited degenerative diseases, it is possible to gain new understanding of how diseases arise and search for medicines that are able to prevent the degeneration. In the long run, stem cells will be used in new treatments. Ian is a strong advocate of a proposal to develop a global network of cell banks, making it possible for anyone in the world to have access to such cell therapy.

Affiliations and Expertise

Director, MRC Centre for Regenerative Medicine, Edinburgh, UK

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