Essentials of Stem Cell Biology - 2nd Edition - ISBN: 9780123747297, 9780080884974

Essentials of Stem Cell Biology

2nd Edition

Editors: John Gearhart Brigid Hogan Douglas Melton Roger Pedersen E. Donnall Thomas James Thomson Ian Wilmut
eBook ISBN: 9780080884974
Hardcover ISBN: 9780123747297
Imprint: Academic Press
Published Date: 22nd June 2009
Page Count: 680
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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

Key Features

  • Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
  • Contributions by Nobel Laureates and leading international investigators
  • Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough
  • Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate
  • Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references


researchers, grad students, and professionals working with human stem cells in biology, tissue engineering, genetics, cancer research, virology, immunology, and biotechnology

Table of Contents


Why Stem Cell Research? A New Path ?{ Induced Pluripotent Stem Cells Embryonic Stem Cells Versus Adult Stem Cells 'Stemness': Definitions, Criteria and Standards


  1. Present Perspective and Future Challenges
  2. Embryonic Stem Cells in Perspective
  3. The Development of Epithelial Stem Cell Concepts
  4. The Advent of Direct Reprogramming
  5. Clinical Translation of Stem Cells


  1. Molecular Basis of Pluripotency
  2. Stem Cell Niches
  3. Mechanisms of Stem Cell Self-Renewal
  4. Cell Cycle Regulators in Stem Cells
  5. Epigenetic Mechanisms of Cellular Memory
  6. Cell Fusion and the Differentiated State
  7. How Cells Change Their Phenotype


  1. Differentiation in Early Development
  2. Primordial Germ Cells in Mouse and Human
  3. Stem Cells in Extraembryonic Lineages
  4. Amniotic Fluid Derived Pluripotent Cells
  5. Cord Blood Stem Cells
  6. Neurogenesis in the Vertebrate Embryo
  7. The Nervous System
  8. Neuronal Progenitors in the Adult Brain
  9. Sensory Epithelium of the Eye and Ear
  10. Epithelial Skin Stem Cells
  11. The Ontogeny of the Hematopoietic System
  12. Hematopoietic Stem Cells
  13. Red Blood Cells
  14. Cell Differentiation in the Skeleton
  15. Vascular Progenitor Cells
  16. Multipotent Adult Progenitor Cells
  17. Mesenchymal Stem Cells
  18. Skeletal Muscle Stem Cells
  19. Stem Cells and the Regenerating Heart
  20. Potential of ES Cell Differentiation Culture for Vascular Biology
  21. Cell Lineages and Stem Cells in the Kidney
  22. Adult Liver Stem Cells
  23. Pancreatic Stem Cells
  24. Stem Cells in the Gastrointestinal Tract
  25. Stem Cells in the Lung


  1. Generation of Induced Pluripotent Stem Cells
  2. Characteristics and Characterization of Pluripotent Stem Cells
  3. Isolation and Maintenance of Murine Embryonic Stem Cells
  4. Isolation, Characterization, and Maintenance of Primate ES Cells
  5. Approaches for Derivation and Maintenance of Human ES cells: Detailed Procedures and Alternatives
  6. Derivation and Differentiation of Human EG Cells
  7. Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells
  8. Feeder-Free Culture
  9. Genetic Manipulation of Human Embryonic Stem Cells
  10. Homologous Recombination in Human Embryonic Stem Cells
  11. Surface Antigen Markers
  12. Lineage Marking
  13. Genomic Reprogramming
  14. Isolation and Characterization of Hematopoietic Stem Cells
  15. Microarray Analysis of Stem Cells and Differentiation
  16. Zebrafish and Stem Cell Research


  1. Cancer Stem Cells
  2. Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases
  3. Spinal Cord Injury
  4. Use of Embryonic Stem Cells to Treat Heart Disease
  5. Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes
  6. Burns and Skin Ulcers 978-0-12-370465-8
  7. Stem Cells and Heart Disease
  8. Stem Cells for the Treatment of Muscular Dystropy
  9. Skin Regeneration
  10. Orthopaedic Applications of Stem Cells
  11. Embryonic Stem Cells in Tissue Engineering
  12. Adult Stem Cells in Tissue Engineering
  13. Stem Cell Gene Therapy


  1. Ethical Considerations
  2. Religious Considerations
  3. Regulatory Considerations
  4. It¡¦s Not About Curiosity, It¡¦s About Cures
    Epilogue: Concluding Statement


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© Academic Press 2009
Academic Press
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About the Editor

John Gearhart

Affiliations and Expertise

Johns Hopkins University School of Medicine, Baltimore, MD, USA

Brigid Hogan

Affiliations and Expertise

Duke University Medical Center, Durham, NC, USA

Douglas Melton

Affiliations and Expertise

Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA

Roger Pedersen

Affiliations and Expertise

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, UK

E. Donnall Thomas

Affiliations and Expertise

Director Emeritus, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

James Thomson

Affiliations and Expertise

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

Ian Wilmut

Affiliations and Expertise

Director, MRC Centre for Regenerative Medicine, Edinburgh, UK


Doody’s Core Titles 2013: Core Purchase, Doody Enterprises

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