Essentials of Stem Cell Biology

2nd Edition

Editors: Robert Lanza John Gearhart Brigid Hogan Douglas Melton Roger Pedersen E. Donnall Thomas James Thomson Ian Wilmut
Hardcover ISBN: 9780123747297
eBook ISBN: 9780080884974
Imprint: Academic Press
Published Date: 22nd June 2009
Page Count: 680
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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

Key Features

  • Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
  • Contributions by Nobel Laureates and leading international investigators
  • Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough
  • Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate
  • Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references


researchers, grad students, and professionals working with human stem cells in biology, tissue engineering, genetics, cancer research, virology, immunology, and biotechnology

Table of Contents


Why Stem Cell Research? A New Path ?{ Induced Pluripotent Stem Cells Embryonic Stem Cells Versus Adult Stem Cells 'Stemness': Definitions, Criteria and Standards


  1. Present Perspective and Future Challenges
  2. Embryonic Stem Cells in Perspective
  3. The Development of Epithelial Stem Cell Concepts
  4. The Advent of Direct Reprogramming
  5. Clinical Translation of Stem Cells


  1. Molecular Basis of Pluripotency
  2. Stem Cell Niches
  3. Mechanisms of Stem Cell Self-Renewal
  4. Cell Cycle Regulators in Stem Cells
  5. Epigenetic Mechanisms of Cellular Memory
  6. Cell Fusion and the Differentiated State
  7. How Cells Change Their Phenotype


  1. Differentiation in Early Development
  2. Primordial Germ Cells in Mouse and Human
  3. Stem Cells in Extraembryonic Lineages
  4. Amniotic Fluid Derived Pluripotent Cells
  5. Cord Blood Stem Cells
  6. Neurogenesis in the Vertebrate Embryo
  7. The Nervous System
  8. Neuronal Progenitors in the Adult Brain
  9. Sensory Epithelium of the Eye and Ear
  10. Epithelial Skin Stem Cells
  11. The Ontogeny of the Hematopoietic System
  12. Hematopoietic Stem Cells
  13. Red Blood Cells
  14. Cell Differentiation in the Skeleton
  15. Vascular Progenitor Cells
  16. Multipotent Adult Progenitor Cells
  17. Mesenchymal Stem Cells
  18. Skeletal Muscle


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© Academic Press 2009
Academic Press
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About the Editor

Robert Lanza

Robert Lanza, M.D. is currently Chief Scientific Officer at Advanced Cell Technology, and Adjunct Professor of Surgical Sciences at Wake Forest University School of Medicine. He has several hundred scientific publications and patents, and over 30 books, including Principles of Tissue Engineering (1st through 4th Editions), Methods of Tissue Engineering, Principles of Cloning (1st and 2nd Editions), Essentials of Stem Cell Biology (1st and 2nd Editions), XENO, Yearbook of Cell & Tissue Transplantation, One World: The Health & Survival of the Human Species in the 21st Century (as editor, with forewords by C. Everett Koop and former President Jimmy Carter), and Medical Science & the Advancement of World Health. Dr. Lanza received his B.A. and M.D. degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. He is a former Fulbright Scholar, and studied as a student in the laboratory of Richard Hynes (MIT), Jonas Salk (The Salk Institute), and Nobel laureates Gerald Edelman (Rockefeller University) and Rodney Porter (Oxford University). He also worked closely (and coauthored a series of papers) with the late Harvard psychologist B.F. Skinner and heart transplant pioneer Christiaan Barnard. Dr. Lanza's current area of research focuses on the use of stem cells in regenerative medicine.

Affiliations and Expertise

Advanced Cell Technology, MA, USA

John Gearhart

Affiliations and Expertise

Johns Hopkins University School of Medicine, Baltimore, MD, USA

Brigid Hogan

Affiliations and Expertise

Duke University Medical Center, Durham, NC, USA

Douglas Melton

Affiliations and Expertise

Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA

Roger Pedersen

Affiliations and Expertise

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, UK

E. Donnall Thomas

Affiliations and Expertise

Director Emeritus, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

James Thomson

Affiliations and Expertise

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

Ian Wilmut

Affiliations and Expertise

Director, MRC Centre for Regenerative Medicine, Edinburgh, UK


Doody’s Core Titles 2013: Core Purchase, Doody Enterprises